H2XQT1_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

H2XQT1_CIOIN

Uncharacterized protein. (117 aa)

Predicted Functional Partners:

F6ZE60_CIOIN

0.540

F6UNP2_CIOIN

0.540

F6YDG1_CIOIN

0.540

F6ZZ26_CIOIN

0.540

LOC113474520

0.540

F6RG85_CIOIN

0.540

F7B1X4_CIOIN

0.540

LOC100182501

0.540

F6XWY9_CIOIN

0.540

F6SSU2_CIOIN

0.540

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6RG85_CIOIN	F6SSU2_CIOIN	ENSCINP00000009676	ENSCINP00000016408	RING-type domain-containing protein.	TPR_REGION domain-containing protein.	0.540
F6RG85_CIOIN	F6UNP2_CIOIN	ENSCINP00000009676	ENSCINP00000001981	RING-type domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.541
F6RG85_CIOIN	F6XWY9_CIOIN	ENSCINP00000009676	ENSCINP00000015343	RING-type domain-containing protein.	TPR_REGION domain-containing protein.	0.540
F6RG85_CIOIN	F6YDG1_CIOIN	ENSCINP00000009676	ENSCINP00000005419	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.549
F6RG85_CIOIN	F6ZE60_CIOIN	ENSCINP00000009676	ENSCINP00000000838	RING-type domain-containing protein.	ANAPC4 domain-containing protein.	0.540
F6RG85_CIOIN	F6ZZ26_CIOIN	ENSCINP00000009676	ENSCINP00000005674	RING-type domain-containing protein.	RING-type domain-containing protein.	0.594
F6RG85_CIOIN	F7B1X4_CIOIN	ENSCINP00000009676	ENSCINP00000012774	RING-type domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.541
F6RG85_CIOIN	H2XQT1_CIOIN	ENSCINP00000009676	ENSCINP00000032015	RING-type domain-containing protein.	Uncharacterized protein.	0.540
F6RG85_CIOIN	LOC100182501	ENSCINP00000009676	ENSCINP00000014260	RING-type domain-containing protein.	TPR_REGION domain-containing protein.	0.548
F6RG85_CIOIN	LOC113474520	ENSCINP00000009676	ENSCINP00000007095	RING-type domain-containing protein.	Uncharacterized protein LOC113474520.	0.540
F6SSU2_CIOIN	F6RG85_CIOIN	ENSCINP00000016408	ENSCINP00000009676	TPR_REGION domain-containing protein.	RING-type domain-containing protein.	0.540
F6SSU2_CIOIN	F6UNP2_CIOIN	ENSCINP00000016408	ENSCINP00000001981	TPR_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.972
F6SSU2_CIOIN	F6XWY9_CIOIN	ENSCINP00000016408	ENSCINP00000015343	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.999
F6SSU2_CIOIN	F6YDG1_CIOIN	ENSCINP00000016408	ENSCINP00000005419	TPR_REGION domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
F6SSU2_CIOIN	F6ZE60_CIOIN	ENSCINP00000016408	ENSCINP00000000838	TPR_REGION domain-containing protein.	ANAPC4 domain-containing protein.	0.999
F6SSU2_CIOIN	F6ZZ26_CIOIN	ENSCINP00000016408	ENSCINP00000005674	TPR_REGION domain-containing protein.	RING-type domain-containing protein.	0.540
F6SSU2_CIOIN	F7B1X4_CIOIN	ENSCINP00000016408	ENSCINP00000012774	TPR_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.961
F6SSU2_CIOIN	H2XQT1_CIOIN	ENSCINP00000016408	ENSCINP00000032015	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.540
F6SSU2_CIOIN	LOC100182501	ENSCINP00000016408	ENSCINP00000014260	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.999
F6SSU2_CIOIN	LOC113474520	ENSCINP00000016408	ENSCINP00000007095	TPR_REGION domain-containing protein.	Uncharacterized protein LOC113474520.	0.540

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

1.06e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

3 of 13

2.54

1.61

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30572

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and HCN channels

9 of 30

2.66

9.23

1.61e-19

CL:30574

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and Polypeptide N-acetylgalactosaminyltransferase activity

8 of 18

2.83

9.07

2.19e-18

CL:30577

Mixed, incl. Synaptonemal complex protein 2-like, and Rab-GTPase-TBC domain

5 of 6

3.1

5.88

1.49e-11

CL:30595

Vps55/LEPROT, and Uncharacterised protein family UPF0220

3 of 5

2.96

2.81

7.42e-06

CL:19564

Dystrophin-associated glycoprotein complex, and EF-hand

2 of 14

2.33

0.87

0.0251

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016012

Sarcoglycan complex

2 of 5

2.78

1.04

0.0129

GOCC:0005927

Muscle tendon junction

2 of 6

2.7

1.04

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05255

Uncharacterised protein family (UPF0220)

2 of 2

3.18

1.3

0.0046

PF04790

Sarcoglycan complex subunit protein

2 of 5

2.78

1.15

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007919

Uncharacterised protein family UPF0220

2 of 2

3.18

1.02

0.0145

IPR039972

Sarcoglycan gamma/delta/zeta

2 of 4

2.88

0.97

0.0181

IPR006875

Sarcoglycan complex subunit protein

2 of 5

2.78

0.96

0.0181

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