H2XSC5_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

H2XSC5_CIOIN

Uncharacterized protein; Belongs to the peptidase S10 family. (103 aa)

Predicted Functional Partners:

LOC100175630

0.549

F6ZG25_CIOIN

0.532

F7BLL7_CIOIN

0.526

F6VR85_CIOIN

0.526

F6VAW2_CIOIN

0.482

F6ZL50_CIOIN

0.474

F6R8L5_CIOIN

0.419

F6UMQ0_CIOIN

0.413

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6R8L5_CIOIN	F6VAW2_CIOIN	ENSCINP00000006011	ENSCINP00000010583	Uncharacterized protein.	Uncharacterized protein.	0.996
F6R8L5_CIOIN	F6ZG25_CIOIN	ENSCINP00000006011	ENSCINP00000012542	Uncharacterized protein.	Uncharacterized protein.	0.996
F6R8L5_CIOIN	H2XSC5_CIOIN	ENSCINP00000006011	ENSCINP00000032559	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.419
F6UMQ0_CIOIN	F6VR85_CIOIN	ENSCINP00000013971	ENSCINP00000024634	Carboxypeptidase; Belongs to the peptidase S10 family.	Uncharacterized protein.	0.466
F6UMQ0_CIOIN	F6ZG25_CIOIN	ENSCINP00000013971	ENSCINP00000012542	Carboxypeptidase; Belongs to the peptidase S10 family.	Uncharacterized protein.	0.408
F6UMQ0_CIOIN	F7BLL7_CIOIN	ENSCINP00000013971	ENSCINP00000024468	Carboxypeptidase; Belongs to the peptidase S10 family.	Glyco_hydro_35 domain-containing protein; Belongs to the glycosyl hydrolase 35 family.	0.466
F6UMQ0_CIOIN	H2XSC5_CIOIN	ENSCINP00000013971	ENSCINP00000032559	Carboxypeptidase; Belongs to the peptidase S10 family.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.413
F6VAW2_CIOIN	F6R8L5_CIOIN	ENSCINP00000010583	ENSCINP00000006011	Uncharacterized protein.	Uncharacterized protein.	0.996
F6VAW2_CIOIN	F6ZG25_CIOIN	ENSCINP00000010583	ENSCINP00000012542	Uncharacterized protein.	Uncharacterized protein.	0.994
F6VAW2_CIOIN	H2XSC5_CIOIN	ENSCINP00000010583	ENSCINP00000032559	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.482
F6VR85_CIOIN	F6UMQ0_CIOIN	ENSCINP00000024634	ENSCINP00000013971	Uncharacterized protein.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.466
F6VR85_CIOIN	H2XSC5_CIOIN	ENSCINP00000024634	ENSCINP00000032559	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.526
F6ZG25_CIOIN	F6R8L5_CIOIN	ENSCINP00000012542	ENSCINP00000006011	Uncharacterized protein.	Uncharacterized protein.	0.996
F6ZG25_CIOIN	F6UMQ0_CIOIN	ENSCINP00000012542	ENSCINP00000013971	Uncharacterized protein.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.408
F6ZG25_CIOIN	F6VAW2_CIOIN	ENSCINP00000012542	ENSCINP00000010583	Uncharacterized protein.	Uncharacterized protein.	0.994
F6ZG25_CIOIN	H2XSC5_CIOIN	ENSCINP00000012542	ENSCINP00000032559	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.532
F6ZL50_CIOIN	H2XSC5_CIOIN	ENSCINP00000022444	ENSCINP00000032559	Sortilin_C domain-containing protein.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.474
F7BLL7_CIOIN	F6UMQ0_CIOIN	ENSCINP00000024468	ENSCINP00000013971	Glyco_hydro_35 domain-containing protein; Belongs to the glycosyl hydrolase 35 family.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.466
F7BLL7_CIOIN	H2XSC5_CIOIN	ENSCINP00000024468	ENSCINP00000032559	Glyco_hydro_35 domain-containing protein; Belongs to the glycosyl hydrolase 35 family.	Uncharacterized protein; Belongs to the peptidase S10 family.	0.526
H2XSC5_CIOIN	F6R8L5_CIOIN	ENSCINP00000032559	ENSCINP00000006011	Uncharacterized protein; Belongs to the peptidase S10 family.	Uncharacterized protein.	0.419

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.875

expected number of edges:

42

PPI enrichment p-value:

0.998

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.4

2.03

1.16e-07

GO:0006355

Regulation of transcription, DNA-templated

7 of 133

1.13

1.24

1.59e-05

GO:0050896

Response to stimulus

9 of 226

1.01

1.14

1.27e-06

GO:0050794

Regulation of cellular process

9 of 241

0.98

1.08

1.89e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043565

Sequence-specific DNA binding

5 of 22

1.77

2.14

1.31e-05

GO:0003677

DNA binding

7 of 194

0.97

0.84

0.00058

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1982

Sigma-54 interaction domain, ATP-binding site 1, and Alpha/beta hydrolase fold-1

4 of 11

1.97

2.16

3.42e-05

CL:1804

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

9 of 100

1.37

2.14

4.16e-09

CL:1803

Mixed, incl. Signaling, and Cilium

10 of 174

1.17

1.64

4.16e-09

CL:1819

PAS-associated, C-terminal, and cheY-homologous receiver domain

4 of 40

1.41

1.18

0.0013

CL:1811

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

5 of 70

1.27

1.13

0.00072

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mro02020

Two-component system

5 of 71

1.26

1.16

0.00048

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

7 of 70

1.41

1.95

5.02e-07

KW-0805

Transcription regulation

4 of 73

1.15

0.8

0.0073

KW-0067

ATP-binding

7 of 231

0.89

0.76

0.00067

KW-0238

DNA-binding

4 of 111

0.97

0.58

0.0231

KW-0418

Kinase

4 of 132

0.89

0.5

0.0374

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02954

Bacterial regulatory protein, Fis family

3 of 11

1.85

1.08

0.0073

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

7 of 62

1.46

1.97

1.38e-06

IPR011006

CheY-like superfamily

7 of 63

1.46

1.96

1.38e-06

IPR002078

RNA polymerase sigma factor 54 interaction domain

4 of 15

1.84

1.76

0.00019

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 55

1.37

1.27

0.00046

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 55

1.37

1.27

0.00046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

7 of 59

1.49

2.24

9.11e-08

SM00388

His Kinase A (phosphoacceptor) domain

6 of 59

1.42

1.83

2.70e-06

SM00382

ATPases associated with a variety of cellular activities

4 of 61

1.23

0.95

0.0028

SM00091

PAS domain

3 of 33

1.37

0.94

0.0065

SM00387

Histidine kinase-like ATPases

4 of 68

1.18

0.91

0.0031

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