LOC100176837 protein (Ciona intestinalis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

gene co-occurrence

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LOC100176837

Mitochondrial import inner membrane translocase subunit TIM8; Belongs to the small Tim family. (89 aa)

Predicted Functional Partners:

H2Y167_CIOIN

0.998

H2XZW2_CIOIN

0.980

H2XWM7_CIOIN

0.898

LOC100183112

0.778

H2XY09_CIOIN

0.776

LOC100187325

0.765

LOC100180381

0.668

LOC100185391

0.653

H2XZV2_CIOIN

0.625

LOC100175733

0.614

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2XWM7_CIOIN	H2XY09_CIOIN	ENSCINP00000034061	ENSCINP00000034543	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.785
H2XWM7_CIOIN	H2XZW2_CIOIN	ENSCINP00000034061	ENSCINP00000035196	zf-Tim10_DDP domain-containing protein.	zf-Tim10_DDP domain-containing protein.	0.999
H2XWM7_CIOIN	H2Y167_CIOIN	ENSCINP00000034061	ENSCINP00000035651	zf-Tim10_DDP domain-containing protein.	Mitochondrial import inner membrane translocase subunit Tim13; Belongs to the small Tim family.	0.943
H2XWM7_CIOIN	LOC100175733	ENSCINP00000034061	ENSCINP00000025217	zf-Tim10_DDP domain-containing protein.	Metaxin-1-like.	0.538
H2XWM7_CIOIN	LOC100176837	ENSCINP00000034061	ENSCINP00000032972	zf-Tim10_DDP domain-containing protein.	Mitochondrial import inner membrane translocase subunit TIM8; Belongs to the small Tim family.	0.898
H2XWM7_CIOIN	LOC100180381	ENSCINP00000034061	ENSCINP00000022199	zf-Tim10_DDP domain-containing protein.	Mitochondrial import inner membrane translocase subunit Tim17-B-like.	0.858
H2XWM7_CIOIN	LOC100183112	ENSCINP00000034061	ENSCINP00000011764	zf-Tim10_DDP domain-containing protein.	Mitochondrial intermembrane space import and assembly protein 40-A-like isoform X2.	0.826
H2XWM7_CIOIN	LOC100185391	ENSCINP00000034061	ENSCINP00000031729	zf-Tim10_DDP domain-containing protein.	Cytochrome c oxidase copper chaperone.	0.653
H2XWM7_CIOIN	LOC100187325	ENSCINP00000034061	ENSCINP00000030609	zf-Tim10_DDP domain-containing protein.	Mitochondrial import inner membrane translocase subunit Tim23.	0.850
H2XY09_CIOIN	H2XWM7_CIOIN	ENSCINP00000034543	ENSCINP00000034061	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein.	0.785
H2XY09_CIOIN	H2XZW2_CIOIN	ENSCINP00000034543	ENSCINP00000035196	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein.	0.733
H2XY09_CIOIN	H2Y167_CIOIN	ENSCINP00000034543	ENSCINP00000035651	Uncharacterized protein.	Mitochondrial import inner membrane translocase subunit Tim13; Belongs to the small Tim family.	0.648
H2XY09_CIOIN	LOC100175733	ENSCINP00000034543	ENSCINP00000025217	Uncharacterized protein.	Metaxin-1-like.	0.803
H2XY09_CIOIN	LOC100176837	ENSCINP00000034543	ENSCINP00000032972	Uncharacterized protein.	Mitochondrial import inner membrane translocase subunit TIM8; Belongs to the small Tim family.	0.776
H2XY09_CIOIN	LOC100180381	ENSCINP00000034543	ENSCINP00000022199	Uncharacterized protein.	Mitochondrial import inner membrane translocase subunit Tim17-B-like.	0.682
H2XY09_CIOIN	LOC100183112	ENSCINP00000034543	ENSCINP00000011764	Uncharacterized protein.	Mitochondrial intermembrane space import and assembly protein 40-A-like isoform X2.	0.572
H2XY09_CIOIN	LOC100187325	ENSCINP00000034543	ENSCINP00000030609	Uncharacterized protein.	Mitochondrial import inner membrane translocase subunit Tim23.	0.809
H2XZV2_CIOIN	H2XZW2_CIOIN	ENSCINP00000035186	ENSCINP00000035196	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein.	0.476
H2XZV2_CIOIN	LOC100176837	ENSCINP00000035186	ENSCINP00000032972	Uncharacterized protein.	Mitochondrial import inner membrane translocase subunit TIM8; Belongs to the small Tim family.	0.625
H2XZV2_CIOIN	LOC100180381	ENSCINP00000035186	ENSCINP00000022199	Uncharacterized protein.	Mitochondrial import inner membrane translocase subunit Tim17-B-like.	0.414

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

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