STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H2XTM9_CIOINATP-cone domain-containing protein. (31 aa)    
Predicted Functional Partners:
F6TAK8_CIOIN
Uncharacterized protein.
   
 0.974
LOC100183847
dUTPase domain-containing protein.
  
 
 0.883
F7BA18_CIOIN
DNA helicase; Belongs to the MCM family.
   
 
 0.853
LOC100176589
DNA helicase; Belongs to the MCM family.
   
 
 0.813
LOC100184693
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 
 0.812
F6UM48_CIOIN
Uncharacterized protein.
    
 0.791
F6RKM9_CIOIN
DNA helicase; Belongs to the MCM family.
   
 
 0.789
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 
 0.788
LOC100181600
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.766
F7AK54_CIOIN
Glutaredoxin domain-containing protein.
  
 0.747
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.