H2Y062_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

H2Y062_CIOIN

Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (417 aa)

Predicted Functional Partners:

LOC100184829

0.736

H2XL14_CIOIN

0.736

F6W2N4_CIOIN

0.734

F6R9A6_CIOIN

0.734

H2XJZ0_CIOIN

0.734

F6YP95_CIOIN

0.687

H2Y004_CIOIN

0.607

F6W6I5_CIOIN

0.509

LOC100182536

0.506

F6XHQ2_CIOIN

0.489

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6R9A6_CIOIN	F6W2N4_CIOIN	ENSCINP00000009967	ENSCINP00000004629	Uncharacterized protein.	Uncharacterized protein.	0.979
F6R9A6_CIOIN	F6W6I5_CIOIN	ENSCINP00000009967	ENSCINP00000004087	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.926
F6R9A6_CIOIN	F6YP95_CIOIN	ENSCINP00000009967	ENSCINP00000011422	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.879
F6R9A6_CIOIN	H2XJZ0_CIOIN	ENSCINP00000009967	ENSCINP00000029972	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.913
F6R9A6_CIOIN	H2Y004_CIOIN	ENSCINP00000009967	ENSCINP00000035238	Uncharacterized protein.	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.977
F6R9A6_CIOIN	H2Y062_CIOIN	ENSCINP00000009967	ENSCINP00000035296	Uncharacterized protein.	Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.734
F6W2N4_CIOIN	F6R9A6_CIOIN	ENSCINP00000004629	ENSCINP00000009967	Uncharacterized protein.	Uncharacterized protein.	0.979
F6W2N4_CIOIN	F6YP95_CIOIN	ENSCINP00000004629	ENSCINP00000011422	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.879
F6W2N4_CIOIN	H2XJZ0_CIOIN	ENSCINP00000004629	ENSCINP00000029972	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.832
F6W2N4_CIOIN	H2Y004_CIOIN	ENSCINP00000004629	ENSCINP00000035238	Uncharacterized protein.	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.977
F6W2N4_CIOIN	H2Y062_CIOIN	ENSCINP00000004629	ENSCINP00000035296	Uncharacterized protein.	Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.734
F6W6I5_CIOIN	F6R9A6_CIOIN	ENSCINP00000004087	ENSCINP00000009967	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.926
F6W6I5_CIOIN	F6YP95_CIOIN	ENSCINP00000004087	ENSCINP00000011422	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Guanylate kinase-like domain-containing protein.	0.535
F6W6I5_CIOIN	H2Y004_CIOIN	ENSCINP00000004087	ENSCINP00000035238	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.815
F6W6I5_CIOIN	H2Y062_CIOIN	ENSCINP00000004087	ENSCINP00000035296	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.509
F6XHQ2_CIOIN	H2XL14_CIOIN	ENSCINP00000007633	ENSCINP00000030346	Uncharacterized protein.	Uncharacterized protein.	0.646
F6XHQ2_CIOIN	H2Y062_CIOIN	ENSCINP00000007633	ENSCINP00000035296	Uncharacterized protein.	Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.489
F6XHQ2_CIOIN	LOC100184829	ENSCINP00000007633	ENSCINP00000019763	Uncharacterized protein.	Protein cornichon homolog 4.	0.646
F6YP95_CIOIN	F6R9A6_CIOIN	ENSCINP00000011422	ENSCINP00000009967	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.879
F6YP95_CIOIN	F6W2N4_CIOIN	ENSCINP00000011422	ENSCINP00000004629	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.879

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.623

expected number of edges:

10

PPI enrichment p-value:

2.77e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 340

1.06

1.39

2.78e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

11 of 341

1.06

1.4

1.61e-09

GO:0015562

Efflux transmembrane transporter activity

3 of 15

1.85

1.28

0.0028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

11 of 1202

0.52

0.44

0.00026

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6452

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein

11 of 29

2.13

7.43

2.33e-20

CL:6454

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein

10 of 23

2.19

7.21

1.83e-18

CL:6483

Palmitate, and Hydrophobe/amphiphile efflux-1 HAE1

5 of 6

2.47

4.41

2.18e-09

CL:6455

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein, barrel-sandwich domain

3 of 14

1.88

1.52

0.00081

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01501

beta-Lactam resistance

10 of 86

1.62

3.61

6.23e-14

map01503

Cationic antimicrobial peptide (CAMP) resistance

7 of 74

1.53

2.45

2.33e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990281

Efflux pump complex

5 of 14

2.11

3.5

3.35e-08

GOCC:1902495

Transmembrane transporter complex

7 of 42

1.78

3.4

7.02e-10

GOCC:0016021

Integral component of membrane

11 of 128

1.49

3.1

2.12e-14

GOCC:0098796

Membrane protein complex

10 of 124

1.46

2.81

1.57e-12

GOCC:0046930

Pore complex

3 of 29

1.57

1.17

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0564

Palmitate

3 of 3

2.55

2.41

3.18e-05

KW-0175

Coiled coil

10 of 373

0.98

1.15

1.32e-07

KW-1134

Transmembrane beta strand

3 of 29

1.57

1.07

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13533

Biotin-lipoyl like

5 of 10

2.25

3.46

1.04e-07

PF13437

HlyD family secretion protein

4 of 13

2.04

2.27

2.32e-05

PF02321

Outer membrane efflux protein

4 of 13

2.04

2.27

2.32e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006143

RND efflux pump, membrane fusion protein

6 of 12

2.25

4.15

2.41e-09

IPR032317

RND efflux pump, membrane fusion protein, barrel-sandwich domain

5 of 11

2.21

3.31

1.86e-07

IPR003423

Outer membrane efflux protein

4 of 13

2.04

2.18

3.78e-05

IPR010131

RND efflux system, outer membrane lipoprotein, NodT

3 of 3

2.55

2.11

0.00012

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