STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H2Y2G5_CIOINMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)    
Predicted Functional Partners:
LOC100180815
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.999
LOC101242128
Uncharacterized protein.
  
 0.973
LOC100186763
60S ribosomal protein L5.
  
 0.973
rl32
Uncharacterized protein.
  
 0.972
F6XBT4_CIOIN
Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.
  
 0.970
LOC100179536
60S ribosomal protein L35.
  
 0.970
LOC100176316
60S ribosomal protein L23a-like; Belongs to the universal ribosomal protein uL23 family.
  
 0.970
H2XKP6_CIOIN
Ribosomal_L14e domain-containing protein.
  
 0.968
LOC100184404
60S ribosomal protein L17-like; Belongs to the universal ribosomal protein uL22 family.
  
 0.967
LOC100186361
60S ribosomal protein L6.
  
 0.966
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.