LOC100178294 protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC100178294

Uncharacterized protein. (765 aa)

Predicted Functional Partners:

LOC100181925

0.956

F6SWU7_CIOIN

0.911

F6WMT5_CIOIN

0.906

F6WUM1_CIOIN

0.899

F6Q9T0_CIOIN

0.864

H2XT98_CIOIN

0.853

LOC100179894

0.828

H2XKT2_CIOIN

0.828

F6VD75_CIOIN

0.816

H2XJN2_CIOIN

0.797

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q9T0_CIOIN	F6VD75_CIOIN	ENSCINP00000018150	ENSCINP00000003159	Uncharacterized protein.	Uncharacterized protein.	0.960
F6Q9T0_CIOIN	H2XJN2_CIOIN	ENSCINP00000018150	ENSCINP00000029864	Uncharacterized protein.	RECA_2 domain-containing protein.	0.867
F6Q9T0_CIOIN	H2XT98_CIOIN	ENSCINP00000018150	ENSCINP00000032882	Uncharacterized protein.	RECA_2 domain-containing protein.	0.714
F6Q9T0_CIOIN	LOC100178294	ENSCINP00000018150	ENSCINP00000036432	Uncharacterized protein.	Uncharacterized protein.	0.864
F6Q9T0_CIOIN	LOC100179894	ENSCINP00000018150	ENSCINP00000004562	Uncharacterized protein.	Werner syndrome ATP-dependent helicase homolog isoform X1.	0.586
F6Q9T0_CIOIN	LOC100181925	ENSCINP00000018150	ENSCINP00000033009	Uncharacterized protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily.	0.903
F6SWU7_CIOIN	LOC100178294	ENSCINP00000002643	ENSCINP00000036432	Uncharacterized protein.	Uncharacterized protein.	0.911
F6VD75_CIOIN	F6Q9T0_CIOIN	ENSCINP00000003159	ENSCINP00000018150	Uncharacterized protein.	Uncharacterized protein.	0.960
F6VD75_CIOIN	H2XJN2_CIOIN	ENSCINP00000003159	ENSCINP00000029864	Uncharacterized protein.	RECA_2 domain-containing protein.	0.785
F6VD75_CIOIN	H2XKT2_CIOIN	ENSCINP00000003159	ENSCINP00000030264	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.979
F6VD75_CIOIN	H2XT98_CIOIN	ENSCINP00000003159	ENSCINP00000032882	Uncharacterized protein.	RECA_2 domain-containing protein.	0.700
F6VD75_CIOIN	LOC100178294	ENSCINP00000003159	ENSCINP00000036432	Uncharacterized protein.	Uncharacterized protein.	0.816
F6VD75_CIOIN	LOC100179894	ENSCINP00000003159	ENSCINP00000004562	Uncharacterized protein.	Werner syndrome ATP-dependent helicase homolog isoform X1.	0.979
F6VD75_CIOIN	LOC100181925	ENSCINP00000003159	ENSCINP00000033009	Uncharacterized protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily.	0.937
F6WMT5_CIOIN	LOC100178294	ENSCINP00000018738	ENSCINP00000036432	HSA domain-containing protein.	Uncharacterized protein.	0.906
F6WUM1_CIOIN	LOC100178294	ENSCINP00000007664	ENSCINP00000036432	Uncharacterized protein.	Uncharacterized protein.	0.899
H2XJN2_CIOIN	F6Q9T0_CIOIN	ENSCINP00000029864	ENSCINP00000018150	RECA_2 domain-containing protein.	Uncharacterized protein.	0.867
H2XJN2_CIOIN	F6VD75_CIOIN	ENSCINP00000029864	ENSCINP00000003159	RECA_2 domain-containing protein.	Uncharacterized protein.	0.785
H2XJN2_CIOIN	H2XKT2_CIOIN	ENSCINP00000029864	ENSCINP00000030264	RECA_2 domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.982
H2XJN2_CIOIN	H2XT98_CIOIN	ENSCINP00000029864	ENSCINP00000032882	RECA_2 domain-containing protein.	RECA_2 domain-containing protein.	0.560

page 1 of 3

Network Stats

number of nodes:

6

number of edges:

12

average node degree:

4

avg. local clustering coefficient:

0.844

expected number of edges:

5

PPI enrichment p-value:

0.00633

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019221

Cytokine-mediated signaling pathway

6 of 259

1.91

3.19

1.47e-07

GO:0050829

Defense response to Gram-negative bacterium

3 of 21

2.7

2.62

4.32e-05

GO:0002920

Regulation of humoral immune response

3 of 20

2.72

2.62

4.32e-05

GO:0002225

Positive regulation of antimicrobial peptide production

2 of 2

3.55

2.17

0.00031

GO:0050830

Defense response to Gram-positive bacterium

3 of 57

2.27

2.02

0.00032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004896

Cytokine receptor activity

3 of 96

2.04

1.26

0.0063

GO:0005125

Cytokine activity

3 of 128

1.92

1.24

0.0063

GO:0048018

Receptor ligand activity

4 of 439

1.51

1.08

0.0063

GO:0046982

Protein heterodimerization activity

3 of 284

1.57

0.88

0.0218

GO:0046983

Protein dimerization activity

4 of 938

1.18

0.69

0.0264

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31523510

(2019) Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.

3 of 14

2.88

2.61

4.88e-05

PMID:36712402

(2023) Functionality of dietary antimicrobial peptides in aquatic animal health: Multiple meta-analyses.

2 of 10

2.85

1.2

0.0111

PMID:28094307

(2017) A transcriptome analysis focusing on inflammation-related genes of grass carp intestines following infection with Aeromonas hydrophila.

2 of 15

2.67

1.11

0.0153

PMID:31649660

(2019) A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.

2 of 28

2.4

0.87

0.0365

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19672

Regulation of IFNG signaling, and STAT protein, protein interaction domain

5 of 22

2.9

5.77

1.77e-10

CL:19706

Interleukin-10/19/20/22/24/26 family, and Regulation of IFNG signaling

4 of 5

3.45

5.67

5.46e-10

CL:34679

SEFIR domain, and Interleukin-17 family

3 of 10

3.02

3.4

2.48e-06

CL:34682

Regulation of antimicrobial peptide production, and Interleukin-17 receptor, fibronectin-III-like domain 1

2 of 5

3.15

1.97

0.00061

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04060

Cytokine-cytokine receptor interaction

6 of 254

1.92

3.79

2.68e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6785807

Interleukin-4 and Interleukin-13 signaling

4 of 42

2.53

3.55

7.24e-07

MAP-877312

Regulation of IFNG signaling

3 of 13

2.91

3.22

4.68e-06

MAP-5663205

Infectious disease

4 of 98

2.16

2.89

4.68e-06

MAP-912694

Regulation of IFNA/IFNB signaling

3 of 27

2.59

2.78

2.03e-05

MAP-1643685

Disease

4 of 174

1.91

2.3

2.95e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070743

interleukin-23 complex

3 of 7

3.18

3.39

2.79e-06

GOCC:0005615

Extracellular space

4 of 522

1.43

1.04

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06083

Interleukin-17

3 of 8

3.12

3.19

5.90e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020440

Interleukin-17, chordata

3 of 6

3.25

3.13

7.70e-06

IPR010345

Interleukin-17 family

3 of 6

3.25

3.13

7.70e-06

IPR020443

Interleukin-10/19/20/22/24/26 family

2 of 3

3.37

1.8

0.0012

IPR029034

Cystine-knot cytokine

3 of 60

2.25

1.7

0.0012

IPR009079

Four-helical cytokine-like, core

2 of 23

2.49

0.96

0.0258

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