Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
S4R7L0_PETMAC3H1-type domain-containing protein. (104 aa)    
Predicted Functional Partners:
S4RP44_PETMA
Ubiquitin-like domain-containing protein.
    
  0.936
S4RQA2_PETMA
Ion_trans domain-containing protein.
    
 0.932
S4RTA2_PETMA
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.887
S4RBH4_PETMA
MIF4G domain-containing protein.
    
 
 0.831
S4RZB9_PETMA
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
     
 0.811
PPARD
Peroxisome proliferator activated receptor delta.
    
 
 0.743
S4RLF2_PETMA
Vestigial-like family member 4b.
      
 0.666
S4RUR4_PETMA
LHFPL tetraspan subfamily member 5b.
      
 0.666
S4RNL4_PETMA
WWE domain-containing protein.
     
 0.665
UBB
Ubiquitin B.
   
  0.658
Your Current Organism:
Petromyzon marinus
NCBI taxonomy Id: 7757
Other names: P. marinus, marine lamprey, sea lamprey, sea lampreys
Server load: low (16%) [HD]