| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMT2 | S4R840_PETMA | ENSPMAP00000006997 | ENSPMAP00000001371 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | 0.504 |
| BMT2 | S4R887_PETMA | ENSPMAP00000006997 | ENSPMAP00000001418 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Si:ch211-125a15.1. | 0.970 |
| BMT2 | S4R959_PETMA | ENSPMAP00000006997 | ENSPMAP00000001740 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3-like, GATOR1 complex subunit. | 0.892 |
| BMT2 | S4R9M5_PETMA | ENSPMAP00000006997 | ENSPMAP00000001906 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2 like, GATOR1 complex subunit. | 0.915 |
| BMT2 | S4RKY3_PETMA | ENSPMAP00000006997 | ENSPMAP00000005866 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein. | 0.969 |
| BMT2 | S4RPR8_PETMA | ENSPMAP00000006997 | ENSPMAP00000007204 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat containing 2. | 0.970 |
| CASTOR1 | S4R840_PETMA | ENSPMAP00000003833 | ENSPMAP00000001371 | Cytosolic arginine sensor for mTORC1 subunit 1. | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | 0.564 |
| CASTOR1 | S4R887_PETMA | ENSPMAP00000003833 | ENSPMAP00000001418 | Cytosolic arginine sensor for mTORC1 subunit 1. | Si:ch211-125a15.1. | 0.798 |
| CASTOR1 | S4R959_PETMA | ENSPMAP00000003833 | ENSPMAP00000001740 | Cytosolic arginine sensor for mTORC1 subunit 1. | NPR3-like, GATOR1 complex subunit. | 0.581 |
| CASTOR1 | S4R9M5_PETMA | ENSPMAP00000003833 | ENSPMAP00000001906 | Cytosolic arginine sensor for mTORC1 subunit 1. | NPR2 like, GATOR1 complex subunit. | 0.559 |
| CASTOR1 | S4RIT1_PETMA | ENSPMAP00000003833 | ENSPMAP00000005113 | Cytosolic arginine sensor for mTORC1 subunit 1. | WD repeat domain 59. | 0.757 |
| CASTOR1 | S4RKY3_PETMA | ENSPMAP00000003833 | ENSPMAP00000005866 | Cytosolic arginine sensor for mTORC1 subunit 1. | DEP domain-containing protein. | 0.652 |
| CASTOR1 | S4RPR8_PETMA | ENSPMAP00000003833 | ENSPMAP00000007204 | Cytosolic arginine sensor for mTORC1 subunit 1. | Integrin alpha FG-GAP repeat containing 2. | 0.792 |
| CASTOR1 | WDR24 | ENSPMAP00000003833 | ENSPMAP00000006430 | Cytosolic arginine sensor for mTORC1 subunit 1. | WD repeat domain 24. | 0.931 |
| CASTOR1 | WDR59 | ENSPMAP00000003833 | ENSPMAP00000010184 | Cytosolic arginine sensor for mTORC1 subunit 1. | WD repeat domain 59. | 0.757 |
| S4R840_PETMA | BMT2 | ENSPMAP00000001371 | ENSPMAP00000006997 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.504 |
| S4R840_PETMA | CASTOR1 | ENSPMAP00000001371 | ENSPMAP00000003833 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | Cytosolic arginine sensor for mTORC1 subunit 1. | 0.564 |
| S4R840_PETMA | S4R887_PETMA | ENSPMAP00000001371 | ENSPMAP00000001418 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | Si:ch211-125a15.1. | 0.872 |
| S4R840_PETMA | S4R959_PETMA | ENSPMAP00000001371 | ENSPMAP00000001740 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | NPR3-like, GATOR1 complex subunit. | 0.702 |
| S4R840_PETMA | S4R9M5_PETMA | ENSPMAP00000001371 | ENSPMAP00000001906 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. | NPR2 like, GATOR1 complex subunit. | 0.637 |