node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMT2 | S4R887_PETMA | ENSPMAP00000006997 | ENSPMAP00000001418 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Si:ch211-125a15.1. | 0.877 |
BMT2 | S4R959_PETMA | ENSPMAP00000006997 | ENSPMAP00000001740 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3-like, GATOR1 complex subunit. | 0.794 |
BMT2 | S4R9M5_PETMA | ENSPMAP00000006997 | ENSPMAP00000001906 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2 like, GATOR1 complex subunit. | 0.814 |
BMT2 | S4RKY3_PETMA | ENSPMAP00000006997 | ENSPMAP00000005866 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein. | 0.844 |
BMT2 | S4RPR8_PETMA | ENSPMAP00000006997 | ENSPMAP00000007204 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat containing 2. | 0.852 |
BMT2 | S4S141_PETMA | ENSPMAP00000006997 | ENSPMAP00000011183 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Protein phosphatase 1 regulatory subunit. | 0.888 |
S4R5N3_PETMA | S4R887_PETMA | ENSPMAP00000000513 | ENSPMAP00000001418 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | Si:ch211-125a15.1. | 0.706 |
S4R5N3_PETMA | S4R959_PETMA | ENSPMAP00000000513 | ENSPMAP00000001740 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | NPR3-like, GATOR1 complex subunit. | 0.991 |
S4R5N3_PETMA | S4R9M5_PETMA | ENSPMAP00000000513 | ENSPMAP00000001906 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | NPR2 like, GATOR1 complex subunit. | 0.999 |
S4R5N3_PETMA | S4RIT1_PETMA | ENSPMAP00000000513 | ENSPMAP00000005113 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | WD repeat domain 59. | 0.990 |
S4R5N3_PETMA | S4RKY3_PETMA | ENSPMAP00000000513 | ENSPMAP00000005866 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | DEP domain-containing protein. | 0.993 |
S4R5N3_PETMA | S4RPR8_PETMA | ENSPMAP00000000513 | ENSPMAP00000007204 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | Integrin alpha FG-GAP repeat containing 2. | 0.744 |
S4R5N3_PETMA | WDR24 | ENSPMAP00000000513 | ENSPMAP00000006430 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | WD repeat domain 24. | 0.999 |
S4R5N3_PETMA | WDR59 | ENSPMAP00000000513 | ENSPMAP00000010184 | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | WD repeat domain 59. | 0.990 |
S4R887_PETMA | BMT2 | ENSPMAP00000001418 | ENSPMAP00000006997 | Si:ch211-125a15.1. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.877 |
S4R887_PETMA | S4R5N3_PETMA | ENSPMAP00000001418 | ENSPMAP00000000513 | Si:ch211-125a15.1. | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. | 0.706 |
S4R887_PETMA | S4R959_PETMA | ENSPMAP00000001418 | ENSPMAP00000001740 | Si:ch211-125a15.1. | NPR3-like, GATOR1 complex subunit. | 0.797 |
S4R887_PETMA | S4R9M5_PETMA | ENSPMAP00000001418 | ENSPMAP00000001906 | Si:ch211-125a15.1. | NPR2 like, GATOR1 complex subunit. | 0.985 |
S4R887_PETMA | S4RIT1_PETMA | ENSPMAP00000001418 | ENSPMAP00000005113 | Si:ch211-125a15.1. | WD repeat domain 59. | 0.969 |
S4R887_PETMA | S4RKY3_PETMA | ENSPMAP00000001418 | ENSPMAP00000005866 | Si:ch211-125a15.1. | DEP domain-containing protein. | 0.987 |