S4R8V4_PETMA protein (Petromyzon marinus) - STRING interaction network

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S4R8V4_PETMA

Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (306 aa)

Predicted Functional Partners:

S4RBB3_PETMA

0.830

S4R6G0_PETMA

0.691

S4RNM2_PETMA

0.603

S4RL79_PETMA

0.600

S4RFB2_PETMA

0.595

SMARCAL1

0.594

S4RWU1_PETMA

0.590

S4RHA6_PETMA

0.583

S4RHW3_PETMA

0.583

S4RHX2_PETMA

0.583

Your Current Organism:

Petromyzon marinus

NCBI taxonomy Id: 7757
Other names: P. marinus, marine lamprey, sea lamprey, sea lampreys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S4R6G0_PETMA	S4R8V4_PETMA	ENSPMAP00000000790	ENSPMAP00000001635	SprT-like domain-containing protein.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.691
S4R6G0_PETMA	S4RNM2_PETMA	ENSPMAP00000000790	ENSPMAP00000006808	SprT-like domain-containing protein.	Tyrosyl-DNA phosphodiesterase 1.	0.737
S4R6G0_PETMA	S4RWU1_PETMA	ENSPMAP00000000790	ENSPMAP00000009681	SprT-like domain-containing protein.	Replication protein A2.	0.816
S4R6G0_PETMA	SMARCAL1	ENSPMAP00000000790	ENSPMAP00000000003	SprT-like domain-containing protein.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.531
S4R8V4_PETMA	S4R6G0_PETMA	ENSPMAP00000001635	ENSPMAP00000000790	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	SprT-like domain-containing protein.	0.691
S4R8V4_PETMA	S4RBB3_PETMA	ENSPMAP00000001635	ENSPMAP00000002494	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Receptor for activated C kinase 1.	0.830
S4R8V4_PETMA	S4RFB2_PETMA	ENSPMAP00000001635	ENSPMAP00000003894	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Single-stranded DNA binding protein 1.	0.595
S4R8V4_PETMA	S4RHA6_PETMA	ENSPMAP00000001635	ENSPMAP00000004588	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Uncharacterized protein.	0.583
S4R8V4_PETMA	S4RHW3_PETMA	ENSPMAP00000001635	ENSPMAP00000004795	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Uncharacterized protein.	0.583
S4R8V4_PETMA	S4RHX2_PETMA	ENSPMAP00000001635	ENSPMAP00000004804	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Uncharacterized protein.	0.583
S4R8V4_PETMA	S4RL79_PETMA	ENSPMAP00000001635	ENSPMAP00000005965	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	RNA terminal phosphate cyclase-like 1.	0.600
S4R8V4_PETMA	S4RNM2_PETMA	ENSPMAP00000001635	ENSPMAP00000006808	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Tyrosyl-DNA phosphodiesterase 1.	0.603
S4R8V4_PETMA	S4RWU1_PETMA	ENSPMAP00000001635	ENSPMAP00000009681	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Replication protein A2.	0.590
S4R8V4_PETMA	SMARCAL1	ENSPMAP00000001635	ENSPMAP00000000003	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.594
S4RBB3_PETMA	S4R8V4_PETMA	ENSPMAP00000002494	ENSPMAP00000001635	Receptor for activated C kinase 1.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.830
S4RBB3_PETMA	SMARCAL1	ENSPMAP00000002494	ENSPMAP00000000003	Receptor for activated C kinase 1.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.428
S4RFB2_PETMA	S4R8V4_PETMA	ENSPMAP00000003894	ENSPMAP00000001635	Single-stranded DNA binding protein 1.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.595
S4RFB2_PETMA	S4RL79_PETMA	ENSPMAP00000003894	ENSPMAP00000005965	Single-stranded DNA binding protein 1.	RNA terminal phosphate cyclase-like 1.	0.420
S4RFB2_PETMA	S4RWU1_PETMA	ENSPMAP00000003894	ENSPMAP00000009681	Single-stranded DNA binding protein 1.	Replication protein A2.	0.626
S4RHA6_PETMA	S4R8V4_PETMA	ENSPMAP00000004588	ENSPMAP00000001635	Uncharacterized protein.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.583

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