KMO protein (Petromyzon marinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

KMO

Kynurenine 3-monooxygenase. (244 aa)

Predicted Functional Partners:

KYNU

0.999

AFMID

0.988

S4RF99_PETMA

0.967

S4RI99_PETMA

0.930

S4RYF7_PETMA

0.912

S4RT68_PETMA

0.866

COQ2

0.850

TDO2

0.824

PISD

0.806

S4RT25_PETMA

0.806

Your Current Organism:

Petromyzon marinus

NCBI taxonomy Id: 7757
Other names: P. marinus, marine lamprey, sea lamprey, sea lampreys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFMID	KMO	ENSPMAP00000008091	ENSPMAP00000001699	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynurenine 3-monooxygenase.	0.988
AFMID	KYNU	ENSPMAP00000008091	ENSPMAP00000008578	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.994
AFMID	S4RF99_PETMA	ENSPMAP00000008091	ENSPMAP00000003881	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Aminoadipate aminotransferase.	0.949
AFMID	S4RI99_PETMA	ENSPMAP00000008091	ENSPMAP00000004931	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	3-hydroxyanthranilate 3,4-dioxygenase.	0.736
AFMID	S4RYF7_PETMA	ENSPMAP00000008091	ENSPMAP00000010248	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.619
AFMID	TDO2	ENSPMAP00000008091	ENSPMAP00000000377	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.991
COQ2	KMO	ENSPMAP00000004311	ENSPMAP00000001699	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Kynurenine 3-monooxygenase.	0.850
COQ2	S4RT25_PETMA	ENSPMAP00000004311	ENSPMAP00000008365	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Epoxide hydrolase 2, cytoplasmic.	0.425
COQ2	S4RT68_PETMA	ENSPMAP00000004311	ENSPMAP00000008408	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Farnesyl-diphosphate farnesyltransferase 1.	0.815
KMO	AFMID	ENSPMAP00000001699	ENSPMAP00000008091	Kynurenine 3-monooxygenase.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.988
KMO	COQ2	ENSPMAP00000001699	ENSPMAP00000004311	Kynurenine 3-monooxygenase.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.850
KMO	KYNU	ENSPMAP00000001699	ENSPMAP00000008578	Kynurenine 3-monooxygenase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.999
KMO	PISD	ENSPMAP00000001699	ENSPMAP00000002777	Kynurenine 3-monooxygenase.	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.	0.806
KMO	S4RF99_PETMA	ENSPMAP00000001699	ENSPMAP00000003881	Kynurenine 3-monooxygenase.	Aminoadipate aminotransferase.	0.967
KMO	S4RI99_PETMA	ENSPMAP00000001699	ENSPMAP00000004931	Kynurenine 3-monooxygenase.	3-hydroxyanthranilate 3,4-dioxygenase.	0.930
KMO	S4RT25_PETMA	ENSPMAP00000001699	ENSPMAP00000008365	Kynurenine 3-monooxygenase.	Epoxide hydrolase 2, cytoplasmic.	0.806
KMO	S4RT68_PETMA	ENSPMAP00000001699	ENSPMAP00000008408	Kynurenine 3-monooxygenase.	Farnesyl-diphosphate farnesyltransferase 1.	0.866
KMO	S4RYF7_PETMA	ENSPMAP00000001699	ENSPMAP00000010248	Kynurenine 3-monooxygenase.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.912
KMO	TDO2	ENSPMAP00000001699	ENSPMAP00000000377	Kynurenine 3-monooxygenase.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.824
KYNU	AFMID	ENSPMAP00000008578	ENSPMAP00000008091	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.994