STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
S4RR03_PETMACellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (500 aa)    
Predicted Functional Partners:
S4RSA8_PETMA
Uncharacterized protein.
    
 0.987
WWTR1
WW domain containing transcription regulator 1.
    
 0.941
S4S1L3_PETMA
Uncharacterized protein.
    
 0.909
CHEK1
Checkpoint kinase 1.
    
 0.899
S4RDW5_PETMA
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
    
 0.897
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.
    
 0.888
S4RJD3_PETMA
E1A binding protein p300 a.
    
 0.886
S4RZ01_PETMA
Uncharacterized protein.
    
 0.884
S4RPL8_PETMA
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
 0.879
S4RUC9_PETMA
TAN domain-containing protein.
   
 0.879
Your Current Organism:
Petromyzon marinus
NCBI taxonomy Id: 7757
Other names: P. marinus, marine lamprey, sea lamprey, sea lampreys
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