STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. (430 aa)    
Predicted Functional Partners:
purB
Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.999
guaB
Unannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.999
purH
Unannotated protein.
  
 0.999
argG
Unannotated protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.997
pyrB
Unannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.997
surE
Unannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.996
EHRUM2_04040
Unannotated protein.
  
 0.996
lysC
Unannotated protein; Belongs to the aspartokinase family.
  
 
  0.988
glyA
Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.862
guaA
Unannotated protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.842
Your Current Organism:
Ehrlichia ruminantium
NCBI taxonomy Id: 779
Other names: Cowdria ruminantium, E. ruminantium, Kurlovia ruminantium, Nicollea ruminantium, Rickettsia ruminantium, heartwater rickettsia, strain Welgevonden
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.