Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (455 aa)    
Predicted Functional Partners:
Xaut_3331
TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase domain; KEGG: ppu:PP_4619 maleylacetoacetate isomerase, putative.
 
 
 0.995
Xaut_3332
TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase; Domain of unknown function DUF1969; KEGG: pfo:Pfl_0911 fumarylacetoacetase.
  
 0.989
Xaut_4617
Methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mag:amb2575 lactoylglutathione lyase and related lyase.
  
 
 0.904
Xaut_3334
PFAM: regulatory protein MarR; transcriptional regulator TrmB; KEGG: mes:Meso_2455 transcriptional regulator, MarR family.
 
   
 0.839
Xaut_2396
PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: bbt:BBta_1939 putative fumarylacetoacetate hydrolase.
 
  
 0.694
Xaut_4534
PFAM: transcriptional coactivator/pterin dehydratase; KEGG: gbe:GbCGDNIH1_0777 pterin-4-alpha-carbinolamine dehydratase.
  
  
 0.639
Xaut_1304
PFAM: monooxygenase FAD-binding; KEGG: bja:bll2329 putative monooxygenase.
 
  
 0.627
Xaut_1299
KEGG: pol:Bpro_4534 beta-lactamase-like.
 
    0.588
Xaut_1305
KEGG: bja:bsl2328 hypothetical protein.
 
     0.584
Xaut_1301
PFAM: regulatory protein MarR; KEGG: bja:blr0347 transcriptional regulatory protein.
 
   
 0.563
Your Current Organism:
Xanthobacter autotrophicus
NCBI taxonomy Id: 78245
Other names: X. autotrophicus Py2, Xanthobacter autotrophicus Py2, Xanthobacter autotrophicus str. Py2, Xanthobacter autotrophicus strain Py2, Xanthobacter sp. Py2
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