node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRUM_0521 | BRUM_1060 | BRUM_0521 | BRUM_1060 | Glycerophosphoryl diester phosphodiesterase. | HAD-superfamily hydrolase. | 0.454 |
BRUM_0783 | BRUM_0995 | BRUM_0783 | BRUM_0995 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | Inosine 5-monophosphate dehydrogenase. | 0.406 |
BRUM_0783 | BRUM_1060 | BRUM_0783 | BRUM_1060 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | HAD-superfamily hydrolase. | 0.589 |
BRUM_0783 | glyA | BRUM_0783 | BRUM_1073 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.703 |
BRUM_0995 | BRUM_0783 | BRUM_0995 | BRUM_0783 | Inosine 5-monophosphate dehydrogenase. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.406 |
BRUM_0995 | BRUM_1059 | BRUM_0995 | BRUM_1059 | Inosine 5-monophosphate dehydrogenase. | Hypothetical protein. | 0.405 |
BRUM_0995 | BRUM_1060 | BRUM_0995 | BRUM_1060 | Inosine 5-monophosphate dehydrogenase. | HAD-superfamily hydrolase. | 0.611 |
BRUM_0995 | cmk | BRUM_0995 | BRUM_1033 | Inosine 5-monophosphate dehydrogenase. | Ribosome-associated GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.433 |
BRUM_0995 | glyA | BRUM_0995 | BRUM_1073 | Inosine 5-monophosphate dehydrogenase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.703 |
BRUM_0995 | guaB | BRUM_0995 | BRUM_1356 | Inosine 5-monophosphate dehydrogenase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.958 |
BRUM_1059 | BRUM_0995 | BRUM_1059 | BRUM_0995 | Hypothetical protein. | Inosine 5-monophosphate dehydrogenase. | 0.405 |
BRUM_1059 | BRUM_1060 | BRUM_1059 | BRUM_1060 | Hypothetical protein. | HAD-superfamily hydrolase. | 0.887 |
BRUM_1059 | BRUM_1061 | BRUM_1059 | BRUM_1061 | Hypothetical protein. | FtsJ-like methyltransferase domain protein. | 0.805 |
BRUM_1059 | guaB | BRUM_1059 | BRUM_1356 | Hypothetical protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.515 |
BRUM_1059 | tyrS | BRUM_1059 | BRUM_1058 | Hypothetical protein. | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.729 |
BRUM_1060 | BRUM_0521 | BRUM_1060 | BRUM_0521 | HAD-superfamily hydrolase. | Glycerophosphoryl diester phosphodiesterase. | 0.454 |
BRUM_1060 | BRUM_0783 | BRUM_1060 | BRUM_0783 | HAD-superfamily hydrolase. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.589 |
BRUM_1060 | BRUM_0995 | BRUM_1060 | BRUM_0995 | HAD-superfamily hydrolase. | Inosine 5-monophosphate dehydrogenase. | 0.611 |
BRUM_1060 | BRUM_1059 | BRUM_1060 | BRUM_1059 | HAD-superfamily hydrolase. | Hypothetical protein. | 0.887 |
BRUM_1060 | BRUM_1061 | BRUM_1060 | BRUM_1061 | HAD-superfamily hydrolase. | FtsJ-like methyltransferase domain protein. | 0.824 |