chmp4c protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

chmp4c

Uncharacterized protein. (163 aa)

Predicted Functional Partners:

pdcd6ip

0.992

chmp7

0.985

LOC103181485

0.973

chmp2a

0.968

chmp6

0.965

chmp5

0.958

ptpn23

0.918

snf8

0.907

ist1

0.905

LOC103172897

0.903

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103172897	LOC103181485	ENSCMIP00000007577	ENSCMIP00000027175	Uncharacterized protein.	Charged multivesicular body protein 3-like protein.	0.943
LOC103172897	chmp2a	ENSCMIP00000007577	ENSCMIP00000011904	Uncharacterized protein.	Charged multivesicular body protein 2a.	0.947
LOC103172897	chmp4c	ENSCMIP00000007577	ENSCMIP00000002283	Uncharacterized protein.	Uncharacterized protein.	0.903
LOC103172897	chmp5	ENSCMIP00000007577	ENSCMIP00000042536	Uncharacterized protein.	Charged multivesicular body protein 5-like protein.	0.905
LOC103172897	chmp6	ENSCMIP00000007577	ENSCMIP00000047974	Uncharacterized protein.	Uncharacterized protein.	0.827
LOC103172897	chmp7	ENSCMIP00000007577	ENSCMIP00000040162	Uncharacterized protein.	Uncharacterized protein.	0.983
LOC103172897	ist1	ENSCMIP00000007577	ENSCMIP00000034569	Uncharacterized protein.	IST1-like protein.	0.870
LOC103172897	pdcd6ip	ENSCMIP00000007577	ENSCMIP00000030860	Uncharacterized protein.	BRO1 domain-containing protein.	0.957
LOC103172897	ptpn23	ENSCMIP00000007577	ENSCMIP00000018821	Uncharacterized protein.	Uncharacterized protein.	0.918
LOC103172897	snf8	ENSCMIP00000007577	ENSCMIP00000037508	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.907
LOC103181485	LOC103172897	ENSCMIP00000027175	ENSCMIP00000007577	Charged multivesicular body protein 3-like protein.	Uncharacterized protein.	0.943
LOC103181485	chmp2a	ENSCMIP00000027175	ENSCMIP00000011904	Charged multivesicular body protein 3-like protein.	Charged multivesicular body protein 2a.	0.998
LOC103181485	chmp4c	ENSCMIP00000027175	ENSCMIP00000002283	Charged multivesicular body protein 3-like protein.	Uncharacterized protein.	0.973
LOC103181485	chmp5	ENSCMIP00000027175	ENSCMIP00000042536	Charged multivesicular body protein 3-like protein.	Charged multivesicular body protein 5-like protein.	0.946
LOC103181485	chmp6	ENSCMIP00000027175	ENSCMIP00000047974	Charged multivesicular body protein 3-like protein.	Uncharacterized protein.	0.989
LOC103181485	chmp7	ENSCMIP00000027175	ENSCMIP00000040162	Charged multivesicular body protein 3-like protein.	Uncharacterized protein.	0.981
LOC103181485	ist1	ENSCMIP00000027175	ENSCMIP00000034569	Charged multivesicular body protein 3-like protein.	IST1-like protein.	0.943
LOC103181485	pdcd6ip	ENSCMIP00000027175	ENSCMIP00000030860	Charged multivesicular body protein 3-like protein.	BRO1 domain-containing protein.	0.686
LOC103181485	ptpn23	ENSCMIP00000027175	ENSCMIP00000018821	Charged multivesicular body protein 3-like protein.	Uncharacterized protein.	0.429
LOC103181485	snf8	ENSCMIP00000027175	ENSCMIP00000037508	Charged multivesicular body protein 3-like protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.898

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

2.83e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051382

Kinetochore assembly

3 of 12

2.72

1.93

0.00029

GO:0007059

Chromosome segregation

5 of 220

1.68

1.59

0.00029

GO:0000712

Resolution of meiotic recombination intermediates

2 of 17

2.4

0.87

0.0257

GO:0036297

Interstrand cross-link repair

2 of 25

2.23

0.81

0.0327

GO:0031297

Replication fork processing

2 of 29

2.16

0.78

0.0359

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0080122

AMP transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0015228

Coenzyme A transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0043262

Adenosine-diphosphatase activity

2 of 7

2.78

1.15

0.0082

GO:0015217

ADP transmembrane transporter activity

2 of 9

2.67

1.15

0.0082

GO:0005347

ATP transmembrane transporter activity

2 of 16

2.42

1.01

0.0140

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000775

Chromosome, centromeric region

5 of 150

1.85

2.32

7.01e-06

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.58

0.0014

GO:0043240

Fanconi anaemia nuclear complex

2 of 9

2.67

1.4

0.0028

GO:0000776

Kinetochore

3 of 101

1.8

1.24

0.0030

GO:0005694

Chromosome

6 of 900

1.15

1.03

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4083

Centromere complex assembly, and AMP transport

7 of 16

2.97

8.07

5.63e-16

CL:4087

Centromere complex assembly, and Inner kinetochore

6 of 11

3.06

7.34

2.20e-14

CL:4090

Centromere complex assembly, and Inner kinetochore

3 of 6

3.02

3.0

3.36e-06

CL:2471

Fanconi anaemia nuclear complex, and CENP-S protein

2 of 12

2.55

1.13

0.0085

CL:2198

DNA replication, and Fanconi anemia pathway

3 of 165

1.58

0.8

0.0229

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu03460

Fanconi anemia pathway

2 of 46

1.96

0.76

0.0376

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-774815

Nucleosome assembly

5 of 62

2.23

3.39

1.30e-07

MAP-606279

Deposition of new CENPA-containing nucleosomes at the centromere

5 of 62

2.23

3.39

1.30e-07

MAP-73886

Chromosome Maintenance

5 of 129

1.91

2.64

1.47e-06

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 43

2.17

1.72

0.00049

MAP-141444

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

3 of 108

1.77

1.11

0.0057

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.44

0.0025

GOCC:0000779

Condensed chromosome, centromeric region

3 of 48

2.12

1.36

0.0025

GOCC:0000776

Kinetochore

3 of 54

2.07

1.35

0.0025

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