Gstp1 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

Gstp1

GST N-terminal domain-containing protein. (220 aa)

Predicted Functional Partners:

LOC103184007

0.968

LOC103188028

0.968

LOC103182460

0.966

hpgds

0.958

LOC103178998

0.958

LOC103181611

0.955

gsr

0.931

mgst1

0.930

gpx4

0.929

gss

0.928

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gstp1	LOC103178998	ENSCMIP00000002657	ENSCMIP00000039310	GST N-terminal domain-containing protein.	Glutathione S-transferase 3-like protein.	0.958
Gstp1	LOC103181611	ENSCMIP00000002657	ENSCMIP00000041599	GST N-terminal domain-containing protein.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.955
Gstp1	LOC103182460	ENSCMIP00000002657	ENSCMIP00000038138	GST N-terminal domain-containing protein.	Glutathione S-transferase Mu 3; Belongs to the GST superfamily.	0.966
Gstp1	LOC103184007	ENSCMIP00000002657	ENSCMIP00000033578	GST N-terminal domain-containing protein.	Uncharacterized protein.	0.968
Gstp1	LOC103188028	ENSCMIP00000002657	ENSCMIP00000035339	GST N-terminal domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.968
Gstp1	gpx4	ENSCMIP00000002657	ENSCMIP00000027410	GST N-terminal domain-containing protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.929
Gstp1	gsr	ENSCMIP00000002657	ENSCMIP00000037007	GST N-terminal domain-containing protein.	Uncharacterized protein.	0.931
Gstp1	gss	ENSCMIP00000002657	ENSCMIP00000005210	GST N-terminal domain-containing protein.	Glutathione synthetase.	0.928
Gstp1	hpgds	ENSCMIP00000002657	ENSCMIP00000024789	GST N-terminal domain-containing protein.	Uncharacterized protein.	0.958
Gstp1	mgst1	ENSCMIP00000002657	ENSCMIP00000027207	GST N-terminal domain-containing protein.	Uncharacterized protein.	0.930
LOC103178998	Gstp1	ENSCMIP00000039310	ENSCMIP00000002657	Glutathione S-transferase 3-like protein.	GST N-terminal domain-containing protein.	0.958
LOC103178998	LOC103181611	ENSCMIP00000039310	ENSCMIP00000041599	Glutathione S-transferase 3-like protein.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.920
LOC103178998	LOC103182460	ENSCMIP00000039310	ENSCMIP00000038138	Glutathione S-transferase 3-like protein.	Glutathione S-transferase Mu 3; Belongs to the GST superfamily.	0.960
LOC103178998	LOC103184007	ENSCMIP00000039310	ENSCMIP00000033578	Glutathione S-transferase 3-like protein.	Uncharacterized protein.	0.955
LOC103178998	LOC103188028	ENSCMIP00000039310	ENSCMIP00000035339	Glutathione S-transferase 3-like protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.955
LOC103178998	gpx4	ENSCMIP00000039310	ENSCMIP00000027410	Glutathione S-transferase 3-like protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.927
LOC103178998	gsr	ENSCMIP00000039310	ENSCMIP00000037007	Glutathione S-transferase 3-like protein.	Uncharacterized protein.	0.925
LOC103178998	gss	ENSCMIP00000039310	ENSCMIP00000005210	Glutathione S-transferase 3-like protein.	Glutathione synthetase.	0.927
LOC103178998	hpgds	ENSCMIP00000039310	ENSCMIP00000024789	Glutathione S-transferase 3-like protein.	Uncharacterized protein.	0.969
LOC103178998	mgst1	ENSCMIP00000039310	ENSCMIP00000027207	Glutathione S-transferase 3-like protein.	Uncharacterized protein.	0.919

page 1 of 6

Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.412

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 30

2.45

2.86

3.49e-06

GO:0040031

snRNA modification

3 of 8

2.9

2.63

1.54e-05

GO:0008380

RNA splicing

6 of 351

1.55

1.92

9.26e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 229

1.66

1.86

4.08e-05

GO:0016071

mRNA metabolic process

7 of 575

1.41

1.78

3.85e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

7 of 39

2.58

6.59

6.85e-14

GO:0017070

U6 snRNA binding

4 of 8

3.02

4.21

1.86e-08

GO:0003723

RNA binding

9 of 1208

1.19

1.57

1.37e-07

GO:0097322

7SK snRNA binding

2 of 5

2.92

1.46

0.0023

GO:1901363

Heterocyclic compound binding

10 of 6430

0.51

0.37

0.0105

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030532

Small nuclear ribonucleoprotein complex

5 of 59

2.25

3.5

8.06e-08

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 32

2.42

3.19

6.88e-07

GO:0015030

Cajal body

4 of 36

2.37

3.17

6.88e-07

GO:0071005

U2-type precatalytic spliceosome

4 of 48

2.24

2.95

1.35e-06

GO:1990904

Ribonucleoprotein complex

7 of 598

1.39

1.89

6.88e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19743

Regulation of protein localization to Cajal body, and U6 snRNA 3-end binding

4 of 6

3.15

4.14

2.82e-08

CL:18977

Small nuclear ribonucleoprotein complex, and snRNA binding

5 of 66

2.2

3.24

2.60e-07

CL:19047

Spliceosomal tri-snRNP complex assembly, and U4/U6 x U5 tri-snRNP complex

3 of 10

2.8

2.65

1.34e-05

CL:18979

Spliceosomal snRNP complex, and snRNA binding

4 of 60

2.15

2.46

1.20e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 266

1.5

1.26

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 391

1.43

1.31

0.00051

MAP-8953854

Metabolism of RNA

7 of 946

1.19

1.21

9.46e-05

MAP-72163

mRNA Splicing - Major Pathway

4 of 272

1.49

1.09

0.0034

MAP-72172

mRNA Splicing

4 of 296

1.45

1.06

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

7 of 447

1.52

2.16

5.13e-07

GOCC:0005634

Nucleus

8 of 3501

0.68

0.43

0.0232

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