LOC103174426 protein (Callorhinchus milii) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

LOC103174426

tRNA-synt_1 domain-containing protein. (167 aa)

Predicted Functional Partners:

eef1g

0.902

eprs1

0.877

yars1

0.863

mars1

0.795

dars2

0.749

lars1

0.725

iars1

0.705

iars2

0.697

lars2

0.680

rars2

0.641

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103174426	dars2	ENSCMIP00000003326	ENSCMIP00000009808	tRNA-synt_1 domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.749
LOC103174426	eef1g	ENSCMIP00000003326	ENSCMIP00000016052	tRNA-synt_1 domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.902
LOC103174426	eprs1	ENSCMIP00000003326	ENSCMIP00000043653	tRNA-synt_1 domain-containing protein.	Uncharacterized protein.	0.877
LOC103174426	iars1	ENSCMIP00000003326	ENSCMIP00000019043	tRNA-synt_1 domain-containing protein.	Isoleucyl-tRNA synthetase, cytoplasmic-like protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.705
LOC103174426	iars2	ENSCMIP00000003326	ENSCMIP00000043841	tRNA-synt_1 domain-containing protein.	Isoleucine-tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.697
LOC103174426	lars1	ENSCMIP00000003326	ENSCMIP00000002360	tRNA-synt_1 domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.725
LOC103174426	lars2	ENSCMIP00000003326	ENSCMIP00000024202	tRNA-synt_1 domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.680
LOC103174426	mars1	ENSCMIP00000003326	ENSCMIP00000046099	tRNA-synt_1 domain-containing protein.	WHEP-TRS domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.795
LOC103174426	rars2	ENSCMIP00000003326	ENSCMIP00000029258	tRNA-synt_1 domain-containing protein.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.641
LOC103174426	yars1	ENSCMIP00000003326	ENSCMIP00000032726	tRNA-synt_1 domain-containing protein.	Tyrosine--tRNA ligase.	0.863
dars2	LOC103174426	ENSCMIP00000009808	ENSCMIP00000003326	AA_TRNA_LIGASE_II domain-containing protein.	tRNA-synt_1 domain-containing protein.	0.749
dars2	eprs1	ENSCMIP00000009808	ENSCMIP00000043653	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.986
dars2	iars1	ENSCMIP00000009808	ENSCMIP00000019043	AA_TRNA_LIGASE_II domain-containing protein.	Isoleucyl-tRNA synthetase, cytoplasmic-like protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.775
dars2	iars2	ENSCMIP00000009808	ENSCMIP00000043841	AA_TRNA_LIGASE_II domain-containing protein.	Isoleucine-tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.791
dars2	lars1	ENSCMIP00000009808	ENSCMIP00000002360	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.741
dars2	lars2	ENSCMIP00000009808	ENSCMIP00000024202	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.778
dars2	mars1	ENSCMIP00000009808	ENSCMIP00000046099	AA_TRNA_LIGASE_II domain-containing protein.	WHEP-TRS domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.746
dars2	rars2	ENSCMIP00000009808	ENSCMIP00000029258	AA_TRNA_LIGASE_II domain-containing protein.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.828
dars2	yars1	ENSCMIP00000009808	ENSCMIP00000032726	AA_TRNA_LIGASE_II domain-containing protein.	Tyrosine--tRNA ligase.	0.893
eef1g	LOC103174426	ENSCMIP00000016052	ENSCMIP00000003326	Uncharacterized protein; Belongs to the GST superfamily.	tRNA-synt_1 domain-containing protein.	0.902

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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