| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSCMIP00000004830 | naprt | ENSCMIP00000004830 | ENSCMIP00000003737 | Uncharacterized protein. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.758 |
| LOC103188411 | naprt | ENSCMIP00000025182 | ENSCMIP00000003737 | Hemoglobin subunit alpha; Belongs to the globin family. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.855 |
| LOC103191437 | haao | ENSCMIP00000008449 | ENSCMIP00000008315 | Indoleamine 2,3-dioxygenase 2. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.712 |
| LOC103191437 | kynu | ENSCMIP00000008449 | ENSCMIP00000023401 | Indoleamine 2,3-dioxygenase 2. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.971 |
| LOC103191437 | nadsyn1 | ENSCMIP00000008449 | ENSCMIP00000041066 | Indoleamine 2,3-dioxygenase 2. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.485 |
| LOC103191437 | naprt | ENSCMIP00000008449 | ENSCMIP00000003737 | Indoleamine 2,3-dioxygenase 2. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.780 |
| haao | LOC103191437 | ENSCMIP00000008315 | ENSCMIP00000008449 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | Indoleamine 2,3-dioxygenase 2. | 0.712 |
| haao | kynu | ENSCMIP00000008315 | ENSCMIP00000023401 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.998 |
| haao | nadsyn1 | ENSCMIP00000008315 | ENSCMIP00000041066 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.588 |
| haao | naprt | ENSCMIP00000008315 | ENSCMIP00000003737 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.778 |
| isoc1 | nadsyn1 | ENSCMIP00000011853 | ENSCMIP00000041066 | Isochorismatase domain-containing protein. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.482 |
| isoc1 | naprt | ENSCMIP00000011853 | ENSCMIP00000003737 | Isochorismatase domain-containing protein. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.873 |
| isoc1 | nmnat1 | ENSCMIP00000011853 | ENSCMIP00000010917 | Isochorismatase domain-containing protein. | Nicotinamide-nucleotide adenylyltransferase. | 0.635 |
| isoc1 | nmnat2 | ENSCMIP00000011853 | ENSCMIP00000042906 | Isochorismatase domain-containing protein. | CTP_transf_like domain-containing protein. | 0.635 |
| isoc1 | nmnat3 | ENSCMIP00000011853 | ENSCMIP00000040267 | Isochorismatase domain-containing protein. | Nicotinamide-nucleotide adenylyltransferase. | 0.635 |
| kynu | LOC103191437 | ENSCMIP00000023401 | ENSCMIP00000008449 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | Indoleamine 2,3-dioxygenase 2. | 0.971 |
| kynu | haao | ENSCMIP00000023401 | ENSCMIP00000008315 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.998 |
| kynu | nadsyn1 | ENSCMIP00000023401 | ENSCMIP00000041066 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.528 |
| kynu | naprt | ENSCMIP00000023401 | ENSCMIP00000003737 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.784 |
| nadsyn1 | LOC103191437 | ENSCMIP00000041066 | ENSCMIP00000008449 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Indoleamine 2,3-dioxygenase 2. | 0.485 |