Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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ENSCMIP00000003831Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)    
Predicted Functional Partners:
LOC103173215
Histone H3; Belongs to the histone H3 family.
 
 
 0.913
ENSCMIP00000011641
Histone H3; Belongs to the histone H3 family.
 
 
 0.907
ENSCMIP00000004257
Histone H2B; Belongs to the histone H2B family.
 
 
 0.890
ENSCMIP00000039901
Histone domain-containing protein; Belongs to the histone H2B family.
 
 
 0.873
h3f3a
Histone domain-containing protein.
 
 
 0.854
h3f3b
Histone domain-containing protein.
 
 
 0.837
hat1
Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.
    
 0.836
arid4a
ARID domain-containing protein.
    
 0.824
arid4b
ARID domain-containing protein.
    
 0.824
LOC103187764
Histone H2A; Belongs to the histone H2A family.
   
 0.823
Your Current Organism:
Callorhinchus milii
NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe
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