nkx2-1 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

nkx2-1

Homeobox domain-containing protein. (348 aa)

Predicted Functional Partners:

foxa1

0.639

nfic

0.579

nfia

0.579

crebbp

0.569

foxa2

0.546

LOC103181792

0.499

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103181792	crebbp	ENSCMIP00000047951	ENSCMIP00000016551	Fork-head domain-containing protein.	Uncharacterized protein.	0.423
LOC103181792	nkx2-1	ENSCMIP00000047951	ENSCMIP00000003898	Fork-head domain-containing protein.	Homeobox domain-containing protein.	0.499
crebbp	LOC103181792	ENSCMIP00000016551	ENSCMIP00000047951	Uncharacterized protein.	Fork-head domain-containing protein.	0.423
crebbp	foxa1	ENSCMIP00000016551	ENSCMIP00000003945	Uncharacterized protein.	Fork-head domain-containing protein.	0.572
crebbp	foxa2	ENSCMIP00000016551	ENSCMIP00000045385	Uncharacterized protein.	Fork-head domain-containing protein.	0.572
crebbp	nkx2-1	ENSCMIP00000016551	ENSCMIP00000003898	Uncharacterized protein.	Homeobox domain-containing protein.	0.569
foxa1	crebbp	ENSCMIP00000003945	ENSCMIP00000016551	Fork-head domain-containing protein.	Uncharacterized protein.	0.572
foxa1	nkx2-1	ENSCMIP00000003945	ENSCMIP00000003898	Fork-head domain-containing protein.	Homeobox domain-containing protein.	0.639
foxa2	crebbp	ENSCMIP00000045385	ENSCMIP00000016551	Fork-head domain-containing protein.	Uncharacterized protein.	0.572
foxa2	nkx2-1	ENSCMIP00000045385	ENSCMIP00000003898	Fork-head domain-containing protein.	Homeobox domain-containing protein.	0.546
nfia	nkx2-1	ENSCMIP00000047373	ENSCMIP00000003898	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	Homeobox domain-containing protein.	0.579
nfic	nkx2-1	ENSCMIP00000005606	ENSCMIP00000003898	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	Homeobox domain-containing protein.	0.579
nkx2-1	LOC103181792	ENSCMIP00000003898	ENSCMIP00000047951	Homeobox domain-containing protein.	Fork-head domain-containing protein.	0.499
nkx2-1	crebbp	ENSCMIP00000003898	ENSCMIP00000016551	Homeobox domain-containing protein.	Uncharacterized protein.	0.569
nkx2-1	foxa1	ENSCMIP00000003898	ENSCMIP00000003945	Homeobox domain-containing protein.	Fork-head domain-containing protein.	0.639
nkx2-1	foxa2	ENSCMIP00000003898	ENSCMIP00000045385	Homeobox domain-containing protein.	Fork-head domain-containing protein.	0.546
nkx2-1	nfia	ENSCMIP00000003898	ENSCMIP00000047373	Homeobox domain-containing protein.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.579
nkx2-1	nfic	ENSCMIP00000003898	ENSCMIP00000005606	Homeobox domain-containing protein.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.579