Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC1031801793 beta-hydroxysteroid dehydrogenase; Belongs to the 3-beta-HSD family. (383 aa)    
Predicted Functional Partners:
LOC103180767
Uncharacterized protein.
   
 0.979
srd5a3
S5A_REDUCTASE domain-containing protein.
     
 0.974
LOC103186779
Uncharacterized protein.
   
 0.972
LOC103188165
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
 0.966
hsd17b3
Testosterone 17-beta-dehydrogenase 3.
  
 0.965
LOC103177103
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 0.964
LOC103180710
Uncharacterized protein.
   
 0.960
ENSCMIP00000008488
Sulfotransferase; Belongs to the sulfotransferase 1 family.
   
 
 0.948
ENSCMIP00000010303
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.945
LOC103191276
Corticosteroid 11-beta-dehydrogenase isozyme 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.937
Your Current Organism:
Callorhinchus milii
NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe
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