spast protein (Callorhinchus milii) - STRING interaction network

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spast

Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (593 aa)

Predicted Functional Partners:

ist1

0.894

LOC103179974

0.836

ubxn7

0.752

spidr

0.736

rad51

0.723

chmp6

0.692

ENSCMIP00000005060

0.671

LOC103187939

0.671

wdr90

0.656

chmp7

0.639

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000005060	LOC103187939	ENSCMIP00000005060	ENSCMIP00000030608	NDK domain-containing protein; Belongs to the NDK family.	Uncharacterized protein; Belongs to the NDK family.	0.755
ENSCMIP00000005060	spast	ENSCMIP00000005060	ENSCMIP00000005440	NDK domain-containing protein; Belongs to the NDK family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.671
ENSCMIP00000005060	wdr90	ENSCMIP00000005060	ENSCMIP00000036826	NDK domain-containing protein; Belongs to the NDK family.	Uncharacterized protein.	0.933
LOC103179974	rad51	ENSCMIP00000040132	ENSCMIP00000038027	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.719
LOC103179974	spast	ENSCMIP00000040132	ENSCMIP00000005440	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.836
LOC103179974	spidr	ENSCMIP00000040132	ENSCMIP00000010572	Uncharacterized protein.	Uncharacterized protein.	0.434
LOC103187939	ENSCMIP00000005060	ENSCMIP00000030608	ENSCMIP00000005060	Uncharacterized protein; Belongs to the NDK family.	NDK domain-containing protein; Belongs to the NDK family.	0.755
LOC103187939	spast	ENSCMIP00000030608	ENSCMIP00000005440	Uncharacterized protein; Belongs to the NDK family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.671
LOC103187939	wdr90	ENSCMIP00000030608	ENSCMIP00000036826	Uncharacterized protein; Belongs to the NDK family.	Uncharacterized protein.	0.933
chmp6	chmp7	ENSCMIP00000047974	ENSCMIP00000040162	Uncharacterized protein.	Uncharacterized protein.	0.989
chmp6	ist1	ENSCMIP00000047974	ENSCMIP00000034569	Uncharacterized protein.	IST1-like protein.	0.955
chmp6	spast	ENSCMIP00000047974	ENSCMIP00000005440	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.692
chmp7	chmp6	ENSCMIP00000040162	ENSCMIP00000047974	Uncharacterized protein.	Uncharacterized protein.	0.989
chmp7	ist1	ENSCMIP00000040162	ENSCMIP00000034569	Uncharacterized protein.	IST1-like protein.	0.916
chmp7	spast	ENSCMIP00000040162	ENSCMIP00000005440	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.639
ist1	chmp6	ENSCMIP00000034569	ENSCMIP00000047974	IST1-like protein.	Uncharacterized protein.	0.955
ist1	chmp7	ENSCMIP00000034569	ENSCMIP00000040162	IST1-like protein.	Uncharacterized protein.	0.916
ist1	spast	ENSCMIP00000034569	ENSCMIP00000005440	IST1-like protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.894
rad51	LOC103179974	ENSCMIP00000038027	ENSCMIP00000040132	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	Uncharacterized protein.	0.719
rad51	spast	ENSCMIP00000038027	ENSCMIP00000005440	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.723

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