Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (461 aa)    
Predicted Functional Partners:
aph1b
Gamma-secretase subunit Aph-1b-like protein.
   
 0.960
LOC103181020
Uncharacterized protein.
   
 0.960
notch1
Uncharacterized protein.
    
 0.955
ENSCMIP00000022787
Uncharacterized protein.
   
 0.939
notch2
Uncharacterized protein.
    
 0.925
notch3
Uncharacterized protein.
    
 0.925
psen1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
  
  
0.903
ENSCMIP00000025170
Uncharacterized protein.
   
 0.874
app
BPTI/Kunitz inhibitor domain-containing protein.
    
 
 0.871
ctnnb1
Uncharacterized protein.
    
 
 0.779
Your Current Organism:
Callorhinchus milii
NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe
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