dyrk1a protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

dyrk1a

Protein kinase domain-containing protein. (774 aa)

Predicted Functional Partners:

dcaf7

0.975

rad54l2

0.944

lin52

0.933

ep300

0.895

LOC103185851

0.888

fnta

0.884

crebbp

0.861

rnf168

0.782

lzts2

0.768

reps1

0.736

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103185851	dcaf7	ENSCMIP00000006904	ENSCMIP00000010476	DUF4585 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.918
LOC103185851	dyrk1a	ENSCMIP00000006904	ENSCMIP00000005925	DUF4585 domain-containing protein.	Protein kinase domain-containing protein.	0.888
LOC103185851	fnta	ENSCMIP00000006904	ENSCMIP00000000047	DUF4585 domain-containing protein.	Uncharacterized protein.	0.910
crebbp	dyrk1a	ENSCMIP00000016551	ENSCMIP00000005925	Uncharacterized protein.	Protein kinase domain-containing protein.	0.861
crebbp	ep300	ENSCMIP00000016551	ENSCMIP00000011493	Uncharacterized protein.	Uncharacterized protein.	0.999
dcaf7	LOC103185851	ENSCMIP00000010476	ENSCMIP00000006904	WD_REPEATS_REGION domain-containing protein.	DUF4585 domain-containing protein.	0.918
dcaf7	dyrk1a	ENSCMIP00000010476	ENSCMIP00000005925	WD_REPEATS_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.975
dcaf7	rad54l2	ENSCMIP00000010476	ENSCMIP00000049139	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.715
dcaf7	rnf168	ENSCMIP00000010476	ENSCMIP00000032501	WD_REPEATS_REGION domain-containing protein.	RING-type domain-containing protein.	0.751
dyrk1a	LOC103185851	ENSCMIP00000005925	ENSCMIP00000006904	Protein kinase domain-containing protein.	DUF4585 domain-containing protein.	0.888
dyrk1a	crebbp	ENSCMIP00000005925	ENSCMIP00000016551	Protein kinase domain-containing protein.	Uncharacterized protein.	0.861
dyrk1a	dcaf7	ENSCMIP00000005925	ENSCMIP00000010476	Protein kinase domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.975
dyrk1a	ep300	ENSCMIP00000005925	ENSCMIP00000011493	Protein kinase domain-containing protein.	Uncharacterized protein.	0.895
dyrk1a	fnta	ENSCMIP00000005925	ENSCMIP00000000047	Protein kinase domain-containing protein.	Uncharacterized protein.	0.884
dyrk1a	lin52	ENSCMIP00000005925	ENSCMIP00000040906	Protein kinase domain-containing protein.	Uncharacterized protein.	0.933
dyrk1a	lzts2	ENSCMIP00000005925	ENSCMIP00000046447	Protein kinase domain-containing protein.	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.	0.768
dyrk1a	rad54l2	ENSCMIP00000005925	ENSCMIP00000049139	Protein kinase domain-containing protein.	Uncharacterized protein.	0.944
dyrk1a	reps1	ENSCMIP00000005925	ENSCMIP00000014573	Protein kinase domain-containing protein.	Uncharacterized protein.	0.736
dyrk1a	rnf168	ENSCMIP00000005925	ENSCMIP00000032501	Protein kinase domain-containing protein.	RING-type domain-containing protein.	0.782
ep300	crebbp	ENSCMIP00000011493	ENSCMIP00000016551	Uncharacterized protein.	Uncharacterized protein.	0.999