insr protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

insr

Tyrosine-protein kinase receptor. (1382 aa)

Predicted Functional Partners:

ins

0.996

irs1

0.988

ENSCMIP00000010071

0.986

ENSCMIP00000041019

0.986

ptpn1

0.985

Shc3

0.978

grb10

0.978

shc4

0.978

sh2b2

0.976

grb2

0.966

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000010071	ENSCMIP00000041019	ENSCMIP00000010071	ENSCMIP00000041019	Uncharacterized protein.	Uncharacterized protein.	0.902
ENSCMIP00000010071	Shc3	ENSCMIP00000010071	ENSCMIP00000026948	Uncharacterized protein.	PID domain-containing protein.	0.454
ENSCMIP00000010071	grb10	ENSCMIP00000010071	ENSCMIP00000043895	Uncharacterized protein.	Uncharacterized protein.	0.583
ENSCMIP00000010071	grb2	ENSCMIP00000010071	ENSCMIP00000043216	Uncharacterized protein.	Uncharacterized protein.	0.989
ENSCMIP00000010071	ins	ENSCMIP00000010071	ENSCMIP00000017634	Uncharacterized protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.978
ENSCMIP00000010071	insr	ENSCMIP00000010071	ENSCMIP00000008789	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.986
ENSCMIP00000010071	irs1	ENSCMIP00000010071	ENSCMIP00000018745	Uncharacterized protein.	Uncharacterized protein.	0.901
ENSCMIP00000010071	ptpn1	ENSCMIP00000010071	ENSCMIP00000031923	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type.	0.928
ENSCMIP00000010071	sh2b2	ENSCMIP00000010071	ENSCMIP00000026536	Uncharacterized protein.	PH domain-containing protein.	0.666
ENSCMIP00000010071	shc4	ENSCMIP00000010071	ENSCMIP00000048862	Uncharacterized protein.	Uncharacterized protein.	0.454
ENSCMIP00000041019	ENSCMIP00000010071	ENSCMIP00000041019	ENSCMIP00000010071	Uncharacterized protein.	Uncharacterized protein.	0.902
ENSCMIP00000041019	Shc3	ENSCMIP00000041019	ENSCMIP00000026948	Uncharacterized protein.	PID domain-containing protein.	0.454
ENSCMIP00000041019	grb10	ENSCMIP00000041019	ENSCMIP00000043895	Uncharacterized protein.	Uncharacterized protein.	0.583
ENSCMIP00000041019	grb2	ENSCMIP00000041019	ENSCMIP00000043216	Uncharacterized protein.	Uncharacterized protein.	0.989
ENSCMIP00000041019	ins	ENSCMIP00000041019	ENSCMIP00000017634	Uncharacterized protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.981
ENSCMIP00000041019	insr	ENSCMIP00000041019	ENSCMIP00000008789	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.986
ENSCMIP00000041019	irs1	ENSCMIP00000041019	ENSCMIP00000018745	Uncharacterized protein.	Uncharacterized protein.	0.903
ENSCMIP00000041019	ptpn1	ENSCMIP00000041019	ENSCMIP00000031923	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type.	0.928
ENSCMIP00000041019	sh2b2	ENSCMIP00000041019	ENSCMIP00000026536	Uncharacterized protein.	PH domain-containing protein.	0.666
ENSCMIP00000041019	shc4	ENSCMIP00000041019	ENSCMIP00000048862	Uncharacterized protein.	Uncharacterized protein.	0.454