vegfa protein (Callorhinchus milii) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

vegfa

PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)

Predicted Functional Partners:

kdr

0.950

LOC103190808

0.940

vegfc

0.922

hgf

0.919

LOC103175503

0.914

LOC103184142

0.910

Vegfd

0.910

pdgfd

0.908

pdgfa

0.900

igf1

0.900

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103175503	LOC103184142	ENSCMIP00000045957	ENSCMIP00000002551	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.913
LOC103175503	LOC103190808	ENSCMIP00000045957	ENSCMIP00000008208	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Placenta growth factor-like protein; Belongs to the PDGF/VEGF growth factor family.	0.906
LOC103175503	Vegfd	ENSCMIP00000045957	ENSCMIP00000022360	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.913
LOC103175503	hgf	ENSCMIP00000045957	ENSCMIP00000036417	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.900
LOC103175503	igf1	ENSCMIP00000045957	ENSCMIP00000026047	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	IlGF domain-containing protein.	0.900
LOC103175503	kdr	ENSCMIP00000045957	ENSCMIP00000030094	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.856
LOC103175503	pdgfa	ENSCMIP00000045957	ENSCMIP00000011504	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.906
LOC103175503	pdgfd	ENSCMIP00000045957	ENSCMIP00000039264	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.978
LOC103175503	vegfa	ENSCMIP00000045957	ENSCMIP00000009426	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.914
LOC103175503	vegfc	ENSCMIP00000045957	ENSCMIP00000005405	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.928
LOC103184142	LOC103175503	ENSCMIP00000002551	ENSCMIP00000045957	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.913
LOC103184142	LOC103190808	ENSCMIP00000002551	ENSCMIP00000008208	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Placenta growth factor-like protein; Belongs to the PDGF/VEGF growth factor family.	0.929
LOC103184142	Vegfd	ENSCMIP00000002551	ENSCMIP00000022360	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.900
LOC103184142	hgf	ENSCMIP00000002551	ENSCMIP00000036417	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.900
LOC103184142	igf1	ENSCMIP00000002551	ENSCMIP00000026047	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	IlGF domain-containing protein.	0.900
LOC103184142	kdr	ENSCMIP00000002551	ENSCMIP00000030094	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.771
LOC103184142	pdgfa	ENSCMIP00000002551	ENSCMIP00000011504	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.900
LOC103184142	pdgfd	ENSCMIP00000002551	ENSCMIP00000039264	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.912
LOC103184142	vegfa	ENSCMIP00000002551	ENSCMIP00000009426	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.910
LOC103184142	vegfc	ENSCMIP00000002551	ENSCMIP00000005405	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.960

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Network Stats

number of nodes:

6

number of edges:

12

average node degree:

4

avg. local clustering coefficient:

0.844

expected number of edges:

5

PPI enrichment p-value:

0.00633

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019221

Cytokine-mediated signaling pathway

6 of 259

1.91

3.19

1.47e-07

GO:0050829

Defense response to Gram-negative bacterium

3 of 21

2.7

2.62

4.32e-05

GO:0002920

Regulation of humoral immune response

3 of 20

2.72

2.62

4.32e-05

GO:0002225

Positive regulation of antimicrobial peptide production

2 of 2

3.55

2.17

0.00031

GO:0050830

Defense response to Gram-positive bacterium

3 of 57

2.27

2.02

0.00032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004896

Cytokine receptor activity

3 of 96

2.04

1.26

0.0063

GO:0005125

Cytokine activity

3 of 128

1.92

1.24

0.0063

GO:0048018

Receptor ligand activity

4 of 439

1.51

1.08

0.0063

GO:0046982

Protein heterodimerization activity

3 of 284

1.57

0.88

0.0218

GO:0046983

Protein dimerization activity

4 of 938

1.18

0.69

0.0264

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31523510

(2019) Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.

3 of 14

2.88

2.61

4.88e-05

PMID:36712402

(2023) Functionality of dietary antimicrobial peptides in aquatic animal health: Multiple meta-analyses.

2 of 10

2.85

1.2

0.0111

PMID:28094307

(2017) A transcriptome analysis focusing on inflammation-related genes of grass carp intestines following infection with Aeromonas hydrophila.

2 of 15

2.67

1.11

0.0153

PMID:31649660

(2019) A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.

2 of 28

2.4

0.87

0.0365

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19672

Regulation of IFNG signaling, and STAT protein, protein interaction domain

5 of 22

2.9

5.77

1.77e-10

CL:19706

Interleukin-10/19/20/22/24/26 family, and Regulation of IFNG signaling

4 of 5

3.45

5.67

5.46e-10

CL:34679

SEFIR domain, and Interleukin-17 family

3 of 10

3.02

3.4

2.48e-06

CL:34682

Regulation of antimicrobial peptide production, and Interleukin-17 receptor, fibronectin-III-like domain 1

2 of 5

3.15

1.97

0.00061

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04060

Cytokine-cytokine receptor interaction

6 of 254

1.92

3.79

2.68e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6785807

Interleukin-4 and Interleukin-13 signaling

4 of 42

2.53

3.55

7.24e-07

MAP-877312

Regulation of IFNG signaling

3 of 13

2.91

3.22

4.68e-06

MAP-5663205

Infectious disease

4 of 98

2.16

2.89

4.68e-06

MAP-912694

Regulation of IFNA/IFNB signaling

3 of 27

2.59

2.78

2.03e-05

MAP-1643685

Disease

4 of 174

1.91

2.3

2.95e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070743

interleukin-23 complex

3 of 7

3.18

3.39

2.79e-06

GOCC:0005615

Extracellular space

4 of 522

1.43

1.04

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06083

Interleukin-17

3 of 8

3.12

3.19

5.90e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020440

Interleukin-17, chordata

3 of 6

3.25

3.13

7.70e-06

IPR010345

Interleukin-17 family

3 of 6

3.25

3.13

7.70e-06

IPR020443

Interleukin-10/19/20/22/24/26 family

2 of 3

3.37

1.8

0.0012

IPR029034

Cystine-knot cytokine

3 of 60

2.25

1.7

0.0012

IPR009079

Four-helical cytokine-like, core

2 of 23

2.49

0.96

0.0258

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