| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSCMIP00000027480 | LOC103172547 | ENSCMIP00000027480 | ENSCMIP00000009955 | Mcm10 domain-containing protein. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.985 |
| ENSCMIP00000027480 | LOC103187009 | ENSCMIP00000027480 | ENSCMIP00000015340 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.984 |
| ENSCMIP00000027480 | cdc45 | ENSCMIP00000027480 | ENSCMIP00000033150 | Mcm10 domain-containing protein. | Uncharacterized protein. | 0.996 |
| ENSCMIP00000027480 | cdc6 | ENSCMIP00000027480 | ENSCMIP00000015292 | Mcm10 domain-containing protein. | Uncharacterized protein. | 0.992 |
| ENSCMIP00000027480 | cdt1 | ENSCMIP00000027480 | ENSCMIP00000034693 | Mcm10 domain-containing protein. | CDT1 domain-containing protein. | 0.989 |
| ENSCMIP00000027480 | mcm2 | ENSCMIP00000027480 | ENSCMIP00000046819 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.994 |
| ENSCMIP00000027480 | mcm4 | ENSCMIP00000027480 | ENSCMIP00000013026 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.995 |
| ENSCMIP00000027480 | mcm6 | ENSCMIP00000027480 | ENSCMIP00000018728 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.984 |
| ENSCMIP00000027480 | orc1 | ENSCMIP00000027480 | ENSCMIP00000025035 | Mcm10 domain-containing protein. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.945 |
| ENSCMIP00000027480 | pole | ENSCMIP00000027480 | ENSCMIP00000040412 | Mcm10 domain-containing protein. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.925 |
| LOC103172547 | ENSCMIP00000027480 | ENSCMIP00000009955 | ENSCMIP00000027480 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Mcm10 domain-containing protein. | 0.985 |
| LOC103172547 | LOC103187009 | ENSCMIP00000009955 | ENSCMIP00000015340 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.976 |
| LOC103172547 | cdc45 | ENSCMIP00000009955 | ENSCMIP00000033150 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Uncharacterized protein. | 0.982 |
| LOC103172547 | cdc6 | ENSCMIP00000009955 | ENSCMIP00000015292 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Uncharacterized protein. | 0.988 |
| LOC103172547 | cdt1 | ENSCMIP00000009955 | ENSCMIP00000034693 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | CDT1 domain-containing protein. | 0.992 |
| LOC103172547 | mcm2 | ENSCMIP00000009955 | ENSCMIP00000046819 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.981 |
| LOC103172547 | mcm4 | ENSCMIP00000009955 | ENSCMIP00000013026 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.998 |
| LOC103172547 | mcm6 | ENSCMIP00000009955 | ENSCMIP00000018728 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.970 |
| LOC103172547 | orc1 | ENSCMIP00000009955 | ENSCMIP00000025035 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.982 |
| LOC103172547 | pole | ENSCMIP00000009955 | ENSCMIP00000040412 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.971 |