wac protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

wac

WW domain-containing protein. (647 aa)

Predicted Functional Partners:

cdc5l

0.969

leo1

0.963

snrnp70

0.957

rbm25

0.957

u2af2

0.930

snrpe

0.900

sf3b3

0.897

ENSCMIP00000003367

0.885

ddx46

0.873

ENSCMIP00000000775

0.864

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000000775	leo1	ENSCMIP00000000775	ENSCMIP00000047145	E3 ubiquitin protein ligase.	RNA polymerase-associated protein LEO1.	0.989
ENSCMIP00000000775	wac	ENSCMIP00000000775	ENSCMIP00000010317	E3 ubiquitin protein ligase.	WW domain-containing protein.	0.864
ENSCMIP00000003367	cdc5l	ENSCMIP00000003367	ENSCMIP00000023381	Uncharacterized protein.	Cell division cycle 5-like protein.	0.990
ENSCMIP00000003367	ddx46	ENSCMIP00000003367	ENSCMIP00000012717	Uncharacterized protein.	Uncharacterized protein.	0.982
ENSCMIP00000003367	rbm25	ENSCMIP00000003367	ENSCMIP00000044527	Uncharacterized protein.	Uncharacterized protein.	0.660
ENSCMIP00000003367	sf3b3	ENSCMIP00000003367	ENSCMIP00000031331	Uncharacterized protein.	CPSF_A domain-containing protein.	0.999
ENSCMIP00000003367	snrnp70	ENSCMIP00000003367	ENSCMIP00000024538	Uncharacterized protein.	U1 small nuclear ribonucleoprotein 70 kDa.	0.944
ENSCMIP00000003367	snrpe	ENSCMIP00000003367	ENSCMIP00000037778	Uncharacterized protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.973
ENSCMIP00000003367	u2af2	ENSCMIP00000003367	ENSCMIP00000006457	Uncharacterized protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.986
ENSCMIP00000003367	wac	ENSCMIP00000003367	ENSCMIP00000010317	Uncharacterized protein.	WW domain-containing protein.	0.885
cdc5l	ENSCMIP00000003367	ENSCMIP00000023381	ENSCMIP00000003367	Cell division cycle 5-like protein.	Uncharacterized protein.	0.990
cdc5l	ddx46	ENSCMIP00000023381	ENSCMIP00000012717	Cell division cycle 5-like protein.	Uncharacterized protein.	0.729
cdc5l	sf3b3	ENSCMIP00000023381	ENSCMIP00000031331	Cell division cycle 5-like protein.	CPSF_A domain-containing protein.	0.992
cdc5l	snrnp70	ENSCMIP00000023381	ENSCMIP00000024538	Cell division cycle 5-like protein.	U1 small nuclear ribonucleoprotein 70 kDa.	0.596
cdc5l	snrpe	ENSCMIP00000023381	ENSCMIP00000037778	Cell division cycle 5-like protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.984
cdc5l	u2af2	ENSCMIP00000023381	ENSCMIP00000006457	Cell division cycle 5-like protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.992
cdc5l	wac	ENSCMIP00000023381	ENSCMIP00000010317	Cell division cycle 5-like protein.	WW domain-containing protein.	0.969
ddx46	ENSCMIP00000003367	ENSCMIP00000012717	ENSCMIP00000003367	Uncharacterized protein.	Uncharacterized protein.	0.982
ddx46	cdc5l	ENSCMIP00000012717	ENSCMIP00000023381	Uncharacterized protein.	Cell division cycle 5-like protein.	0.729
ddx46	rbm25	ENSCMIP00000012717	ENSCMIP00000044527	Uncharacterized protein.	Uncharacterized protein.	0.969

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.905

expected number of edges:

14

PPI enrichment p-value:

1.3e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044038

Cell wall macromolecule biosynthetic process

8 of 29

1.71

3.22

7.08e-10

GO:0009273

Peptidoglycan-based cell wall biogenesis

8 of 30

1.69

3.18

7.08e-10

GO:0071555

Cell wall organization

7 of 24

1.73

3.12

3.50e-09

GO:0009252

Peptidoglycan biosynthetic process

6 of 20

1.74

2.79

7.96e-08

GO:0051301

Cell division

7 of 32

1.61

2.67

1.57e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

4 of 8

1.97

1.94

0.00011

GO:0016874

Ligase activity

5 of 75

1.09

0.76

0.0077

GO:0043168

Anion binding

8 of 334

0.65

0.46

0.0084

GO:0036094

Small molecule binding

8 of 352

0.62

0.44

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1122

Peptidoglycan synthesis, and PASTA domain

8 of 12

2.09

5.14

6.38e-13

CL:1121

Cell cycle, and D-Alanine metabolism

9 of 21

1.9

4.64

2.12e-13

CL:1125

Peptidoglycan synthesis, and PASTA domain

4 of 6

2.09

2.58

5.50e-06

CL:1907

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lai00550

Peptidoglycan biosynthesis

7 of 17

1.88

3.76

3.21e-10

lai00473

D-Alanine metabolism

4 of 4

2.27

2.97

1.34e-06

lai01502

Vancomycin resistance

4 of 5

2.17

2.87

1.61e-06

lai00471

D-Glutamine and D-glutamate metabolism

2 of 4

1.97

1.13

0.0067

lai01503

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

1.08

0.0078

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

7 of 13

2.0

4.16

1.32e-10

KW-0573

Peptidoglycan synthesis

6 of 11

2.0

3.67

4.31e-09

KW-0132

Cell division

6 of 30

1.57

2.3

3.26e-07

KW-0131

Cell cycle

6 of 30

1.57

2.3

3.26e-07

KW-0436

Ligase

6 of 63

1.25

1.43

1.25e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

3 of 5

2.05

1.41

0.0019

PF08245

Mur ligase middle domain

3 of 6

1.97

1.39

0.0019

PF01225

Mur ligase family, catalytic domain

2 of 2

2.27

0.97

0.0158

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.05

1.18

0.0055

IPR036565

Mur-like, catalytic domain superfamily

3 of 6

1.97

1.17

0.0055

IPR013221

Mur ligase, central

3 of 6

1.97

1.17

0.0055

IPR000713

Mur ligase, N-terminal catalytic domain

2 of 2

2.27

0.8

0.0338

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