eif4enif1 protein (Callorhinchus milii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

eif4enif1

Uncharacterized protein. (706 aa)

Predicted Functional Partners:

ddx6

0.933

LOC103184817

0.928

lsm14a

0.823

lsm14b

0.766

arid4a

0.687

eif4e1b

0.674

LOC103182130

0.674

LOC103182199

0.674

arid4b

0.658

fancm

0.623

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103182130	LOC103184817	ENSCMIP00000015742	ENSCMIP00000010175	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.674
LOC103182130	ddx6	ENSCMIP00000015742	ENSCMIP00000028373	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Putative ATP-dependent RNA helicase DDX6-like protein; Belongs to the DEAD box helicase family.	0.676
LOC103182130	eif4enif1	ENSCMIP00000015742	ENSCMIP00000010434	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.674
LOC103182130	lsm14b	ENSCMIP00000015742	ENSCMIP00000036198	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.400
LOC103182199	LOC103184817	ENSCMIP00000021019	ENSCMIP00000010175	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.674
LOC103182199	ddx6	ENSCMIP00000021019	ENSCMIP00000028373	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.	Putative ATP-dependent RNA helicase DDX6-like protein; Belongs to the DEAD box helicase family.	0.676
LOC103182199	eif4enif1	ENSCMIP00000021019	ENSCMIP00000010434	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.674
LOC103184817	LOC103182130	ENSCMIP00000010175	ENSCMIP00000015742	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.674
LOC103184817	LOC103182199	ENSCMIP00000010175	ENSCMIP00000021019	Uncharacterized protein.	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.	0.674
LOC103184817	arid4a	ENSCMIP00000010175	ENSCMIP00000002543	Uncharacterized protein.	ARID domain-containing protein.	0.687
LOC103184817	arid4b	ENSCMIP00000010175	ENSCMIP00000026045	Uncharacterized protein.	ARID domain-containing protein.	0.658
LOC103184817	ddx6	ENSCMIP00000010175	ENSCMIP00000028373	Uncharacterized protein.	Putative ATP-dependent RNA helicase DDX6-like protein; Belongs to the DEAD box helicase family.	0.933
LOC103184817	eif4e1b	ENSCMIP00000010175	ENSCMIP00000001011	Uncharacterized protein.	Eukaryotic translation initiation factor 4E-like protein; Belongs to the eukaryotic initiation factor 4E family.	0.674
LOC103184817	eif4enif1	ENSCMIP00000010175	ENSCMIP00000010434	Uncharacterized protein.	Uncharacterized protein.	0.928
LOC103184817	fancm	ENSCMIP00000010175	ENSCMIP00000005855	Uncharacterized protein.	Uncharacterized protein.	0.623
LOC103184817	lsm14a	ENSCMIP00000010175	ENSCMIP00000036704	Uncharacterized protein.	Protein LSM14-like A.	0.823
LOC103184817	lsm14b	ENSCMIP00000010175	ENSCMIP00000036198	Uncharacterized protein.	Uncharacterized protein.	0.766
arid4a	LOC103184817	ENSCMIP00000002543	ENSCMIP00000010175	ARID domain-containing protein.	Uncharacterized protein.	0.687
arid4a	arid4b	ENSCMIP00000002543	ENSCMIP00000026045	ARID domain-containing protein.	ARID domain-containing protein.	0.650
arid4a	eif4enif1	ENSCMIP00000002543	ENSCMIP00000010434	ARID domain-containing protein.	Uncharacterized protein.	0.687

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.825

expected number of edges:

15

PPI enrichment p-value:

0.000447

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072522

Purine-containing compound biosynthetic process

9 of 130

2.02

5.15

9.52e-14

GO:0009152

Purine ribonucleotide biosynthetic process

7 of 116

1.96

3.93

3.73e-10

GO:0009165

Nucleotide biosynthetic process

8 of 182

1.82

3.74

9.16e-11

GO:0043101

Purine-containing compound salvage

4 of 14

2.63

3.63

1.42e-07

GO:0015986

Proton motive force-driven ATP synthesis

4 of 21

2.46

3.26

5.41e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

3 of 10

2.65

2.03

0.00018

GO:0015078

Proton transmembrane transporter activity

4 of 103

1.77

1.55

0.00052

GO:0004731

Purine-nucleoside phosphorylase activity

2 of 3

3.0

1.45

0.0024

GO:0016874

Ligase activity

4 of 151

1.6

1.26

0.0017

GO:0016763

Pentosyltransferase activity

3 of 57

1.9

1.24

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 18

2.52

3.13

1.19e-06

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 6

2.88

2.74

9.43e-06

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 4

2.88

1.59

0.0013

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

2 of 12

2.4

1.2

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8346

Mitochondrial proton-transporting ATP synthase complex

4 of 19

2.5

2.88

3.46e-06

CL:8374

CF(1), and Mitochondrial depolarization

2 of 5

2.78

1.21

0.0063

CL:24274

Mixed, incl. Pentraxin / C-reactive protein / pentaxin family, and Guanine salvage

2 of 11

2.44

0.94

0.0194

CL:8347

Mitochondrial proton-transporting ATP synthase complex

2 of 14

2.33

0.9

0.0223

CL:11211

Purine ribonucleoside monophosphate biosynthetic process, and GMP reductase complex

2 of 15

2.3

0.9

0.0225

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

5 of 218

1.54

1.76

3.21e-05

map00190

Oxidative phosphorylation

4 of 183

1.52

1.37

0.00057

map04714

Thermogenesis

4 of 229

1.42

1.22

0.0010

map05012

Parkinson disease

4 of 244

1.39

1.2

0.0010

map05020

Prion disease

4 of 266

1.35

1.15

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

4 of 18

2.52

3.26

6.50e-07

MAP-8949613

Cristae formation

4 of 27

2.35

2.95

1.86e-06

MAP-1592230

Mitochondrial biogenesis

4 of 51

2.07

2.42

1.20e-05

MAP-15869

Metabolism of nucleotides

5 of 123

1.79

2.31

4.82e-06

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

4 of 140

1.63

1.47

0.00049

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

4 of 21

2.46

2.95

2.40e-06

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 7

2.81

2.62

1.58e-05

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

2 of 9

2.52

1.15

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0660

Purine salvage

2 of 3

3.0

1.58

0.0014

KW-0139

CF(1)

2 of 3

3.0

1.58

0.0014

KW-0658

Purine biosynthesis

2 of 4

2.88

1.57

0.0014

KW-0375

Hydrogen ion transport

2 of 22

2.14

1.17

0.0062

KW-0328

Glycosyltransferase

3 of 122

1.57

1.08

0.0045

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01048

Phosphorylase superfamily

2 of 4

2.88

1.06

0.0124

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035994

Nucleoside phosphorylase superfamily

2 of 3

3.0

1.12

0.0096

IPR018099

Purine phosphorylase, family 2, conserved site

2 of 2

3.18

1.12

0.0096

IPR000845

Nucleoside phosphorylase domain

2 of 3

3.0

1.12

0.0096

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