mapre2 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

mapre2

Uncharacterized protein. (324 aa)

Predicted Functional Partners:

ckap5

0.824

bub3

0.745

mad2l1

0.734

ENSCMIP00000020011

0.734

LOC103190377

0.684

aurka

0.684

mapre1

0.671

bub1b

0.659

ENSCMIP00000043742

0.659

clip1

0.640

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000020011	ENSCMIP00000043742	ENSCMIP00000020011	ENSCMIP00000043742	HORMA domain-containing protein.	BUB1 N-terminal domain-containing protein.	0.929
ENSCMIP00000020011	LOC103190377	ENSCMIP00000020011	ENSCMIP00000026116	HORMA domain-containing protein.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.718
ENSCMIP00000020011	aurka	ENSCMIP00000020011	ENSCMIP00000032561	HORMA domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.718
ENSCMIP00000020011	bub1b	ENSCMIP00000020011	ENSCMIP00000043738	HORMA domain-containing protein.	Protein kinase domain-containing protein.	0.929
ENSCMIP00000020011	bub3	ENSCMIP00000020011	ENSCMIP00000015801	HORMA domain-containing protein.	Uncharacterized protein.	0.954
ENSCMIP00000020011	ckap5	ENSCMIP00000020011	ENSCMIP00000039062	HORMA domain-containing protein.	Uncharacterized protein.	0.799
ENSCMIP00000020011	clip1	ENSCMIP00000020011	ENSCMIP00000012790	HORMA domain-containing protein.	Uncharacterized protein.	0.484
ENSCMIP00000020011	mapre1	ENSCMIP00000020011	ENSCMIP00000040142	HORMA domain-containing protein.	Uncharacterized protein.	0.773
ENSCMIP00000020011	mapre2	ENSCMIP00000020011	ENSCMIP00000010537	HORMA domain-containing protein.	Uncharacterized protein.	0.734
ENSCMIP00000043742	ENSCMIP00000020011	ENSCMIP00000043742	ENSCMIP00000020011	BUB1 N-terminal domain-containing protein.	HORMA domain-containing protein.	0.929
ENSCMIP00000043742	LOC103190377	ENSCMIP00000043742	ENSCMIP00000026116	BUB1 N-terminal domain-containing protein.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.676
ENSCMIP00000043742	aurka	ENSCMIP00000043742	ENSCMIP00000032561	BUB1 N-terminal domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.676
ENSCMIP00000043742	bub1b	ENSCMIP00000043742	ENSCMIP00000043738	BUB1 N-terminal domain-containing protein.	Protein kinase domain-containing protein.	0.896
ENSCMIP00000043742	bub3	ENSCMIP00000043742	ENSCMIP00000015801	BUB1 N-terminal domain-containing protein.	Uncharacterized protein.	0.970
ENSCMIP00000043742	ckap5	ENSCMIP00000043742	ENSCMIP00000039062	BUB1 N-terminal domain-containing protein.	Uncharacterized protein.	0.729
ENSCMIP00000043742	clip1	ENSCMIP00000043742	ENSCMIP00000012790	BUB1 N-terminal domain-containing protein.	Uncharacterized protein.	0.488
ENSCMIP00000043742	mad2l1	ENSCMIP00000043742	ENSCMIP00000005408	BUB1 N-terminal domain-containing protein.	HORMA domain-containing protein.	0.929
ENSCMIP00000043742	mapre1	ENSCMIP00000043742	ENSCMIP00000040142	BUB1 N-terminal domain-containing protein.	Uncharacterized protein.	0.711
ENSCMIP00000043742	mapre2	ENSCMIP00000043742	ENSCMIP00000010537	BUB1 N-terminal domain-containing protein.	Uncharacterized protein.	0.659
LOC103190377	ENSCMIP00000020011	ENSCMIP00000026116	ENSCMIP00000020011	Aurora kinase B; Belongs to the protein kinase superfamily.	HORMA domain-containing protein.	0.718

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Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.654

expected number of edges:

8

PPI enrichment p-value:

0.0243

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006626

Protein targeting to mitochondrion

8 of 46

2.55

7.4

8.00e-16

GO:0007005

Mitochondrion organization

10 of 344

1.78

4.38

1.68e-14

GO:0051204

Protein insertion into mitochondrial membrane

4 of 15

2.74

3.9

5.16e-08

GO:0030150

Protein import into mitochondrial matrix

4 of 22

2.57

3.56

1.79e-07

GO:0045040

Protein insertion into mitochondrial outer membrane

3 of 4

3.19

3.3

1.03e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

3 of 17

2.56

1.95

0.00025

GO:0030943

Mitochondrion targeting sequence binding

2 of 4

3.01

1.48

0.0021

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005742

Mitochondrial outer membrane translocase complex

11 of 19

3.08

15.21

3.37e-30

GO:0001401

SAM complex

4 of 5

3.22

5.19

3.32e-10

GO:0031307

Integral component of mitochondrial outer membrane

2 of 20

2.31

1.33

0.0033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28762

Outer mitochondrial membrane protein complex

11 of 17

3.12

15.26

4.92e-30

CL:28763

Outer mitochondrial membrane protein complex

9 of 12

3.19

12.42

4.29e-24

CL:28775

Outer mitochondrial membrane protein complex

5 of 6

3.23

6.27

3.26e-12

CL:28765

Outer mitochondrial membrane protein complex

4 of 5

3.22

4.72

2.46e-09

CL:28786

SAM complex, and MAS20 protein import receptor

2 of 5

2.91

1.43

0.0026

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5205685

PINK1-PRKN Mediated Mitophagy

7 of 25

2.76

7.48

3.06e-15

MAP-5205647

Mitophagy

7 of 44

2.51

6.54

5.25e-14

MAP-9663891

Selective autophagy

7 of 94

2.18

5.07

5.16e-12

MAP-9612973

Autophagy

7 of 163

1.95

4.01

1.60e-10

MAP-1632852

Macroautophagy

7 of 163

1.95

4.01

1.60e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098799

Outer mitochondrial membrane protein complex

8 of 15

3.04

10.21

4.36e-20

GOCC:0005742

Mitochondrial outer membrane translocase complex

7 of 11

3.12

9.25

5.12e-18

GOCC:0005741

Mitochondrial outer membrane

10 of 94

2.34

8.37

4.36e-20

GOCC:0001401

SAM complex

4 of 7

3.07

4.89

1.05e-09

GOCC:0005739

Mitochondrion

11 of 878

1.41

2.75

5.98e-14

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1000

Mitochondrion outer membrane

3 of 10

2.79

2.75

8.53e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17171

Glutathione S-transferase, C-terminal domain

2 of 5

2.91

1.12

0.0094

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