malt1 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

malt1

Uncharacterized protein. (104 aa)

Predicted Functional Partners:

casp8

0.900

mapk14

0.900

LOC103179136

0.900

mapk8

0.900

ENSCMIP00000010233

0.900

mapk10

0.900

mapk9

0.900

chuk

0.900

mapk1

0.900

mapk12

0.900

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000010233	LOC103179136	ENSCMIP00000010233	ENSCMIP00000003253	Ig-like domain-containing protein.	Mitogen-activated protein kinase.	0.912
ENSCMIP00000010233	casp8	ENSCMIP00000010233	ENSCMIP00000002279	Ig-like domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.958
ENSCMIP00000010233	chuk	ENSCMIP00000010233	ENSCMIP00000020095	Ig-like domain-containing protein.	Protein kinase domain-containing protein.	0.939
ENSCMIP00000010233	malt1	ENSCMIP00000010233	ENSCMIP00000015870	Ig-like domain-containing protein.	Uncharacterized protein.	0.900
ENSCMIP00000010233	mapk1	ENSCMIP00000010233	ENSCMIP00000032576	Ig-like domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.913
ENSCMIP00000010233	mapk10	ENSCMIP00000010233	ENSCMIP00000013667	Ig-like domain-containing protein.	Mitogen-activated protein kinase.	0.904
ENSCMIP00000010233	mapk12	ENSCMIP00000010233	ENSCMIP00000037413	Ig-like domain-containing protein.	Mitogen-activated protein kinase.	0.912
ENSCMIP00000010233	mapk14	ENSCMIP00000010233	ENSCMIP00000003184	Ig-like domain-containing protein.	Mitogen-activated protein kinase.	0.912
ENSCMIP00000010233	mapk8	ENSCMIP00000010233	ENSCMIP00000007698	Ig-like domain-containing protein.	Mitogen-activated protein kinase.	0.904
ENSCMIP00000010233	mapk9	ENSCMIP00000010233	ENSCMIP00000014768	Ig-like domain-containing protein.	Mitogen-activated protein kinase.	0.904
LOC103179136	ENSCMIP00000010233	ENSCMIP00000003253	ENSCMIP00000010233	Mitogen-activated protein kinase.	Ig-like domain-containing protein.	0.912
LOC103179136	malt1	ENSCMIP00000003253	ENSCMIP00000015870	Mitogen-activated protein kinase.	Uncharacterized protein.	0.900
LOC103179136	mapk1	ENSCMIP00000003253	ENSCMIP00000032576	Mitogen-activated protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.948
casp8	ENSCMIP00000010233	ENSCMIP00000002279	ENSCMIP00000010233	Uncharacterized protein; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.958
casp8	malt1	ENSCMIP00000002279	ENSCMIP00000015870	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.900
chuk	ENSCMIP00000010233	ENSCMIP00000020095	ENSCMIP00000010233	Protein kinase domain-containing protein.	Ig-like domain-containing protein.	0.939
chuk	malt1	ENSCMIP00000020095	ENSCMIP00000015870	Protein kinase domain-containing protein.	Uncharacterized protein.	0.900
malt1	ENSCMIP00000010233	ENSCMIP00000015870	ENSCMIP00000010233	Uncharacterized protein.	Ig-like domain-containing protein.	0.900
malt1	LOC103179136	ENSCMIP00000015870	ENSCMIP00000003253	Uncharacterized protein.	Mitogen-activated protein kinase.	0.900
malt1	casp8	ENSCMIP00000015870	ENSCMIP00000002279	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.900

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007017

Microtubule-based process

8 of 721

1.33

1.67

3.08e-06

GO:0010970

Transport along microtubule

4 of 115

1.83

1.36

0.0017

GO:0032402

Melanosome transport

2 of 11

2.55

0.8

0.0349

GO:1902850

Microtubule cytoskeleton organization involved in mitosis

3 of 109

1.73

0.75

0.0349

GO:0051650

Establishment of vesicle localization

3 of 122

1.68

0.74

0.0349

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005869

Dynactin complex

6 of 15

2.89

6.79

1.52e-13

GO:0005875

Microtubule associated complex

9 of 144

2.08

5.8

3.45e-15

GO:0030286

Dynein complex

4 of 58

2.13

2.63

4.76e-06

GO:0005813

Centrosome

8 of 554

1.45

2.28

1.36e-08

GO:0000776

Kinetochore

4 of 127

1.78

1.88

7.64e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36107127

(2022) Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.

6 of 9

3.11

6.48

1.08e-12

PMID:36071160

(2022) Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

3 of 9

2.81

1.81

0.00051

PMID:33734450

(2021) Cryo-EM reveals the complex architecture of dynactins shoulder region and pointed end.

3 of 8

2.86

1.81

0.00051

PMID:18437411

(2008) The mammalian centrosome and its functional significance.

3 of 18

2.51

1.45

0.0021

PMID:33523880

(2021) The Arp111 minifilament of dynactin primes the endosomal Arp23 complex.

3 of 22

2.42

1.38

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15025

Cytoplasmic dynein complex, and Dynactin complex

11 of 33

2.81

13.02

3.35e-27

CL:15064

Dynactin complex, and F-actin-capping protein subunit alpha/beta

9 of 12

3.16

12.32

5.81e-24

CL:15067

Dynactin complex

7 of 7

3.29

9.61

1.83e-18

CL:15029

Mixed, incl. Dynein light chain, type 1/2, conserved site, and Dynein family light intermediate chain

2 of 7

2.74

1.28

0.0048

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc04962

Vasopressin-regulated water reabsorption

7 of 39

2.54

6.83

1.47e-14

ssc05016

Huntington disease

7 of 260

1.72

3.12

2.35e-09

ssc05014

Amyotrophic lateral sclerosis

7 of 306

1.65

2.87

4.79e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-6811436

COPI-independent Golgi-to-ER retrograde traffic

10 of 39

2.7

10.96

2.74e-23

SSC-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

10 of 40

2.68

10.92

2.74e-23

SSC-6807878

COPI-mediated anterograde transport

10 of 80

2.38

8.85

6.35e-21

SSC-2132295

MHC class II antigen presentation

10 of 119

2.21

7.6

1.63e-19

SSC-380259

Loss of Nlp from mitotic centrosomes

6 of 60

2.29

4.97

3.20e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005869

Dynactin complex

6 of 7

3.22

7.72

6.14e-15

GOCC:0005875

Microtubule associated complex

9 of 123

2.15

6.2

1.12e-15

GOCC:0015630

Microtubule cytoskeleton

10 of 593

1.51

3.0

2.21e-12

GOCC:0030286

Dynein complex

4 of 57

2.13

2.62

4.97e-06

GOCC:0005868

Cytoplasmic dynein complex

2 of 18

2.33

1.08

0.0102

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00132

Bacterial transferase hexapeptide (six repeats)

2 of 4

2.99

1.16

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011004

Trimeric LpxA-like superfamily

2 of 4

2.99

0.91

0.0225

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About