emc7 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

emc7

DUF2012 domain-containing protein. (236 aa)

Predicted Functional Partners:

emc3

0.973

emc1

0.965

emc2

0.965

emc10

0.965

mmgt1

0.963

emc6

0.963

emc8

0.960

unc79

0.678

chmp2a

0.553

psmb2

0.546

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chmp2a	emc7	ENSCMIP00000011904	ENSCMIP00000020408	Charged multivesicular body protein 2a.	DUF2012 domain-containing protein.	0.553
emc1	emc10	ENSCMIP00000013006	ENSCMIP00000045229	EMC1_C domain-containing protein.	Uncharacterized protein.	0.962
emc1	emc2	ENSCMIP00000013006	ENSCMIP00000030159	EMC1_C domain-containing protein.	TPR_REGION domain-containing protein.	0.996
emc1	emc3	ENSCMIP00000013006	ENSCMIP00000044078	EMC1_C domain-containing protein.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.993
emc1	emc6	ENSCMIP00000013006	ENSCMIP00000031677	EMC1_C domain-containing protein.	Uncharacterized protein.	0.978
emc1	emc7	ENSCMIP00000013006	ENSCMIP00000020408	EMC1_C domain-containing protein.	DUF2012 domain-containing protein.	0.965
emc1	emc8	ENSCMIP00000013006	ENSCMIP00000029947	EMC1_C domain-containing protein.	Uncharacterized protein.	0.972
emc1	mmgt1	ENSCMIP00000013006	ENSCMIP00000009276	EMC1_C domain-containing protein.	Uncharacterized protein.	0.976
emc10	emc1	ENSCMIP00000045229	ENSCMIP00000013006	Uncharacterized protein.	EMC1_C domain-containing protein.	0.962
emc10	emc2	ENSCMIP00000045229	ENSCMIP00000030159	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.964
emc10	emc3	ENSCMIP00000045229	ENSCMIP00000044078	Uncharacterized protein.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.963
emc10	emc6	ENSCMIP00000045229	ENSCMIP00000031677	Uncharacterized protein.	Uncharacterized protein.	0.957
emc10	emc7	ENSCMIP00000045229	ENSCMIP00000020408	Uncharacterized protein.	DUF2012 domain-containing protein.	0.965
emc10	emc8	ENSCMIP00000045229	ENSCMIP00000029947	Uncharacterized protein.	Uncharacterized protein.	0.958
emc10	mmgt1	ENSCMIP00000045229	ENSCMIP00000009276	Uncharacterized protein.	Uncharacterized protein.	0.957
emc2	emc1	ENSCMIP00000030159	ENSCMIP00000013006	TPR_REGION domain-containing protein.	EMC1_C domain-containing protein.	0.996
emc2	emc10	ENSCMIP00000030159	ENSCMIP00000045229	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.964
emc2	emc3	ENSCMIP00000030159	ENSCMIP00000044078	TPR_REGION domain-containing protein.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.995
emc2	emc6	ENSCMIP00000030159	ENSCMIP00000031677	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.996
emc2	emc7	ENSCMIP00000030159	ENSCMIP00000020408	TPR_REGION domain-containing protein.	DUF2012 domain-containing protein.	0.965

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.865

expected number of edges:

14

PPI enrichment p-value:

0.155

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

7 of 112

1.58

2.43

1.15e-07

GO:0006810

Transport

10 of 524

1.07

1.31

1.15e-07

GO:0055085

Transmembrane transport

5 of 402

0.88

0.53

0.0253

GO:0009987

Cellular process

11 of 2988

0.35

0.28

0.0139

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060089

Molecular transducer activity

3 of 20

1.96

1.24

0.0038

GO:0022857

Transmembrane transporter activity

6 of 329

1.05

0.79

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

10 of 994

0.79

0.77

6.98e-06

GO:0005886

Plasma membrane

7 of 597

0.85

0.74

0.00038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5456

Mixed, incl. Protein transport, and TonB/TolA, C-terminal

7 of 28

2.18

4.82

2.57e-11

CL:5457

Mixed, incl. Protein transport, and Protein of unknown function DUF421

6 of 23

2.2

4.2

1.22e-09

CL:5458

Mixed, incl. Protein transport, and Protein of unknown function DUF421

5 of 16

2.28

3.72

2.93e-08

CL:5462

Biopolymer transport protein ExbD/TolR, and Outer membrane lipoprotein BamD-like

4 of 5

2.69

3.7

1.17e-07

CL:7092

Mixed, incl. TonB/TolA, C-terminal, and Putative porin

2 of 6

2.31

1.04

0.0122

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

6 of 422

0.94

0.67

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

7 of 23

2.27

5.51

1.14e-12

KW-0812

Transmembrane

9 of 1256

0.64

0.52

0.00077

KW-1133

Transmembrane helix

8 of 1247

0.59

0.43

0.0059

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01618

MotA/TolQ/ExbB proton channel family

5 of 8

2.58

4.39

3.73e-09

PF02472

Biopolymer transport protein ExbD/TolR

2 of 7

2.24

0.82

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002898

MotA/TolQ/ExbB proton channel

5 of 8

2.58

4.2

9.12e-09

IPR006260

TonB/TolA, C-terminal

2 of 2

2.79

1.04

0.0129

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