rgs10 protein (Callorhinchus milii) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

rgs10

Regulator of G-protein signaling 10. (182 aa)

Predicted Functional Partners:

gsk3b

0.672

apc2

0.552

apc

0.552

gnb5

0.532

Rgs21

0.517

LOC103182451

0.503

gnat1

0.503

csnk1a1

0.503

rgs18

0.482

LOC103180040

0.479

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103180040	LOC103182451	ENSCMIP00000045997	ENSCMIP00000037844	Regulator of G-protein signaling 5-like protein.	Uncharacterized protein.	0.637
LOC103180040	Rgs21	ENSCMIP00000045997	ENSCMIP00000046089	Regulator of G-protein signaling 5-like protein.	RGS domain-containing protein.	0.606
LOC103180040	apc	ENSCMIP00000045997	ENSCMIP00000042396	Regulator of G-protein signaling 5-like protein.	Uncharacterized protein.	0.518
LOC103180040	apc2	ENSCMIP00000045997	ENSCMIP00000006641	Regulator of G-protein signaling 5-like protein.	Uncharacterized protein.	0.518
LOC103180040	csnk1a1	ENSCMIP00000045997	ENSCMIP00000048173	Regulator of G-protein signaling 5-like protein.	Protein kinase domain-containing protein.	0.503
LOC103180040	gnat1	ENSCMIP00000045997	ENSCMIP00000042844	Regulator of G-protein signaling 5-like protein.	Uncharacterized protein.	0.637
LOC103180040	gnb5	ENSCMIP00000045997	ENSCMIP00000047205	Regulator of G-protein signaling 5-like protein.	WD_REPEATS_REGION domain-containing protein.	0.726
LOC103180040	gsk3b	ENSCMIP00000045997	ENSCMIP00000001784	Regulator of G-protein signaling 5-like protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.672
LOC103180040	rgs10	ENSCMIP00000045997	ENSCMIP00000021069	Regulator of G-protein signaling 5-like protein.	Regulator of G-protein signaling 10.	0.479
LOC103180040	rgs18	ENSCMIP00000045997	ENSCMIP00000046079	Regulator of G-protein signaling 5-like protein.	RGS domain-containing protein.	0.630
LOC103182451	LOC103180040	ENSCMIP00000037844	ENSCMIP00000045997	Uncharacterized protein.	Regulator of G-protein signaling 5-like protein.	0.637
LOC103182451	Rgs21	ENSCMIP00000037844	ENSCMIP00000046089	Uncharacterized protein.	RGS domain-containing protein.	0.664
LOC103182451	gnat1	ENSCMIP00000037844	ENSCMIP00000042844	Uncharacterized protein.	Uncharacterized protein.	0.901
LOC103182451	gnb5	ENSCMIP00000037844	ENSCMIP00000047205	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.783
LOC103182451	rgs10	ENSCMIP00000037844	ENSCMIP00000021069	Uncharacterized protein.	Regulator of G-protein signaling 10.	0.503
LOC103182451	rgs18	ENSCMIP00000037844	ENSCMIP00000046079	Uncharacterized protein.	RGS domain-containing protein.	0.559
Rgs21	LOC103180040	ENSCMIP00000046089	ENSCMIP00000045997	RGS domain-containing protein.	Regulator of G-protein signaling 5-like protein.	0.606
Rgs21	LOC103182451	ENSCMIP00000046089	ENSCMIP00000037844	RGS domain-containing protein.	Uncharacterized protein.	0.664
Rgs21	apc	ENSCMIP00000046089	ENSCMIP00000042396	RGS domain-containing protein.	Uncharacterized protein.	0.523
Rgs21	apc2	ENSCMIP00000046089	ENSCMIP00000006641	RGS domain-containing protein.	Uncharacterized protein.	0.523

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 14

2.2

4.77

4.05e-11

GO:0000162

Tryptophan biosynthetic process

4 of 4

2.5

3.23

7.12e-07

GO:0046417

Chorismate metabolic process

3 of 9

2.02

1.85

0.00020

GO:0008652

Cellular amino acid biosynthetic process

7 of 99

1.35

1.81

7.12e-07

GO:0019438

Aromatic compound biosynthetic process

10 of 203

1.19

1.71

2.70e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 121

1.2

1.08

0.00060

GO:0016835

Carbon-oxygen lyase activity

4 of 46

1.44

1.03

0.0042

GO:0004834

Tryptophan synthase activity

2 of 2

2.5

1.03

0.0133

GO:0004106

Chorismate mutase activity

2 of 2

2.5

1.03

0.0133

GO:0016836

Hydro-lyase activity

3 of 37

1.41

0.7

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1270

0.4

0.28

0.0388

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30808357

(2019) Metabolic engineering of microorganisms for production of aromatic compounds.

4 of 8

2.2

2.52

1.05e-05

PMID:34584039

(2021) Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.

2 of 2

2.5

1.07

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1391

Aromatic amino acid biosynthesis, and Anthranilate synthase/para-aminobenzoate synthase like domain

10 of 15

2.32

7.99

3.90e-19

CL:1393

Tryptophan biosynthesis

5 of 6

2.42

4.23

4.38e-09

CL:1407

Chorismate metabolic process

3 of 7

2.13

1.88

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pha00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 18

2.15

5.67

5.08e-14

pha01230

Biosynthesis of amino acids

8 of 113

1.35

2.04

1.36e-08

pha00790

Folate biosynthesis

3 of 24

1.6

1.25

0.0018

pha01110

Biosynthesis of secondary metabolites

8 of 287

0.95

0.97

1.13e-05

pha01100

Metabolic pathways

8 of 632

0.6

0.46

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 12

2.27

5.34

3.03e-12

KW-0822

Tryptophan biosynthesis

5 of 5

2.5

4.45

2.07e-09

KW-0456

Lyase

9 of 133

1.33

2.1

1.40e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.5

0.84

0.0299

PF00425

Chorismate binding enzyme

2 of 2

2.5

0.84

0.0299

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.5

1.18

0.0068

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