ENSCMIP00000021239 protein (Callorhinchus milii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSCMIP00000021239

Uncharacterized protein. (167 aa)

Predicted Functional Partners:

ENSCMIP00000004895

0.931

LOC103188191

0.911

ENSCMIP00000021235

0.911

LOC103172586

0.910

ENSCMIP00000021230

0.910

ENSCMIP00000008906

0.909

LOC103173120

0.907

ENSCMIP00000008021

0.907

ENSCMIP00000008017

0.906

LOC103191098

0.899

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000004895	ENSCMIP00000008906	ENSCMIP00000004895	ENSCMIP00000008906	Uncharacterized protein.	Uncharacterized protein.	0.840
ENSCMIP00000004895	ENSCMIP00000021230	ENSCMIP00000004895	ENSCMIP00000021230	Uncharacterized protein.	Uncharacterized protein.	0.906
ENSCMIP00000004895	ENSCMIP00000021239	ENSCMIP00000004895	ENSCMIP00000021239	Uncharacterized protein.	Uncharacterized protein.	0.931
ENSCMIP00000004895	LOC103172586	ENSCMIP00000004895	ENSCMIP00000010204	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSCMIP00000004895	LOC103173120	ENSCMIP00000004895	ENSCMIP00000003808	Uncharacterized protein.	Uncharacterized protein.	0.853
ENSCMIP00000004895	LOC103188191	ENSCMIP00000004895	ENSCMIP00000010766	Uncharacterized protein.	Uncharacterized protein.	0.903
ENSCMIP00000004895	LOC103191098	ENSCMIP00000004895	ENSCMIP00000025855	Uncharacterized protein.	EGF-like domain-containing protein.	0.897
ENSCMIP00000008017	ENSCMIP00000008906	ENSCMIP00000008017	ENSCMIP00000008906	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSCMIP00000008017	ENSCMIP00000021239	ENSCMIP00000008017	ENSCMIP00000021239	Uncharacterized protein.	Uncharacterized protein.	0.906
ENSCMIP00000008017	LOC103172586	ENSCMIP00000008017	ENSCMIP00000010204	Uncharacterized protein.	Uncharacterized protein.	0.910
ENSCMIP00000008017	LOC103188191	ENSCMIP00000008017	ENSCMIP00000010766	Uncharacterized protein.	Uncharacterized protein.	0.926
ENSCMIP00000008017	LOC103191098	ENSCMIP00000008017	ENSCMIP00000025855	Uncharacterized protein.	EGF-like domain-containing protein.	0.884
ENSCMIP00000008021	ENSCMIP00000008906	ENSCMIP00000008021	ENSCMIP00000008906	Uncharacterized protein.	Uncharacterized protein.	0.888
ENSCMIP00000008021	ENSCMIP00000021239	ENSCMIP00000008021	ENSCMIP00000021239	Uncharacterized protein.	Uncharacterized protein.	0.907
ENSCMIP00000008021	LOC103172586	ENSCMIP00000008021	ENSCMIP00000010204	Uncharacterized protein.	Uncharacterized protein.	0.905
ENSCMIP00000008021	LOC103188191	ENSCMIP00000008021	ENSCMIP00000010766	Uncharacterized protein.	Uncharacterized protein.	0.908
ENSCMIP00000008021	LOC103191098	ENSCMIP00000008021	ENSCMIP00000025855	Uncharacterized protein.	EGF-like domain-containing protein.	0.865
ENSCMIP00000008906	ENSCMIP00000004895	ENSCMIP00000008906	ENSCMIP00000004895	Uncharacterized protein.	Uncharacterized protein.	0.840
ENSCMIP00000008906	ENSCMIP00000008017	ENSCMIP00000008906	ENSCMIP00000008017	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSCMIP00000008906	ENSCMIP00000008021	ENSCMIP00000008906	ENSCMIP00000008021	Uncharacterized protein.	Uncharacterized protein.	0.888

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About