LOC103183481 protein (Callorhinchus milii) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103183481

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein. (142 aa)

Predicted Functional Partners:

sod2

0.780

cbs

0.717

dap3

0.666

ybey

0.665

suox

0.656

Rps11

0.608

nfs1

0.593

scly

0.593

mrpl21

0.580

cat

0.577

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103183481	Rps11	ENSCMIP00000022048	ENSCMIP00000034490	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	0.608
LOC103183481	cat	ENSCMIP00000022048	ENSCMIP00000018464	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.577
LOC103183481	cbs	ENSCMIP00000022048	ENSCMIP00000015780	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.717
LOC103183481	dap3	ENSCMIP00000022048	ENSCMIP00000002233	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Uncharacterized protein.	0.666
LOC103183481	mrpl21	ENSCMIP00000022048	ENSCMIP00000017856	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Uncharacterized protein.	0.580
LOC103183481	nfs1	ENSCMIP00000022048	ENSCMIP00000006636	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Aminotran_5 domain-containing protein.	0.593
LOC103183481	scly	ENSCMIP00000022048	ENSCMIP00000024301	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Selenocysteine lyase.	0.593
LOC103183481	sod2	ENSCMIP00000022048	ENSCMIP00000029751	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.780
LOC103183481	suox	ENSCMIP00000022048	ENSCMIP00000003314	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Cytochrome b5 heme-binding domain-containing protein.	0.656
LOC103183481	ybey	ENSCMIP00000022048	ENSCMIP00000036780	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	Uncharacterized protein.	0.665
Rps11	LOC103183481	ENSCMIP00000034490	ENSCMIP00000022048	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	0.608
Rps11	cbs	ENSCMIP00000034490	ENSCMIP00000015780	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.553
Rps11	dap3	ENSCMIP00000034490	ENSCMIP00000002233	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	Uncharacterized protein.	0.987
Rps11	mrpl21	ENSCMIP00000034490	ENSCMIP00000017856	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	Uncharacterized protein.	0.999
Rps11	sod2	ENSCMIP00000034490	ENSCMIP00000029751	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.962
Rps11	ybey	ENSCMIP00000034490	ENSCMIP00000036780	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	Uncharacterized protein.	0.929
cat	LOC103183481	ENSCMIP00000018464	ENSCMIP00000022048	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1-like protein.	0.577
cat	cbs	ENSCMIP00000018464	ENSCMIP00000015780	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.642
cat	sod2	ENSCMIP00000018464	ENSCMIP00000029751	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.953
cat	suox	ENSCMIP00000018464	ENSCMIP00000003314	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Cytochrome b5 heme-binding domain-containing protein.	0.441

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.91

expected number of edges:

11

PPI enrichment p-value:

4.18e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 5

2.73

3.42

4.23e-07

GO:0006289

Nucleotide-excision repair

3 of 11

2.26

1.98

0.00016

GO:0009432

SOS response

3 of 19

2.02

1.66

0.00052

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009381

Excinuclease ABC activity

3 of 10

2.3

1.76

0.00048

GO:0008965

Phosphoenolpyruvate-protein phosphotransferase activity

2 of 2

2.82

1.53

0.0017

GO:0004518

Nuclease activity

4 of 61

1.64

1.48

0.00048

GO:0016887

ATP hydrolysis activity

3 of 61

1.52

0.94

0.0096

GO:0140640

Catalytic activity, acting on a nucleic acid

4 of 245

1.04

0.6

0.0266

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009380

Excinuclease repair complex

3 of 10

2.3

2.11

9.25e-05

GO:0005737

Cytoplasm

8 of 1249

0.63

0.49

0.0024

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:18485189

(2008) Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context.

5 of 6

2.74

5.21

1.31e-10

PMID:26257709

(2015) The reduced genomes of Parcubacteria (OD1) contain signatures of a symbiotic lifestyle.

3 of 24

1.92

1.68

0.00039

PMID:15886391

(2005) An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus.

2 of 5

2.43

1.51

0.0016

PMID:23902135

(2013) GTAG- and CGTC-tagged palindromic DNA repeats in prokaryotes.

2 of 6

2.35

1.5

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9636

Mixed, incl. Import across plasma membrane, and Mannoside phosphorylase

5 of 17

2.29

3.7

3.41e-08

CL:9655

Import across plasma membrane, and Type I phosphodiesterase / nucleotide pyrophosphatase

4 of 6

2.65

3.6

1.72e-07

CL:9634

Mostly uncharacterized, incl. Import across plasma membrane, and Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

6 of 39

2.01

3.41

2.56e-08

CL:915

DNA excision

3 of 6

2.52

2.29

5.26e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rba02060

Phosphotransferase system (PTS)

4 of 5

2.73

3.97

3.71e-08

rba03420

Nucleotide excision repair

3 of 12

2.22

2.17

6.10e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009380

Excinuclease repair complex

3 of 10

2.3

1.97

0.00018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0267

Excision nuclease

3 of 5

2.6

2.43

3.02e-05

KW-0228

DNA excision

3 of 5

2.6

2.43

3.02e-05

KW-0598

Phosphotransferase system

2 of 2

2.82

1.83

0.00046

KW-0762

Sugar transport

2 of 3

2.65

1.75

0.00063

KW-0670

Pyruvate

2 of 13

2.01

1.17

0.0057

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05524

PEP-utilising enzyme, N-terminal

2 of 2

2.82

1.16

0.0079

PF02896

PEP-utilising enzyme, PEP-binding domain

2 of 3

2.65

1.16

0.0079

PF00391

PEP-utilising enzyme, mobile domain

2 of 3

2.65

1.16

0.0079

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041102

UvrA, interaction domain

2 of 3

2.65

0.95

0.0192

IPR036637

Phosphohistidine domain superfamily

2 of 3

2.65

0.95

0.0192

IPR036618

PtsI, HPr-binding domain superfamily

2 of 2

2.82

0.95

0.0192

IPR024692

Phosphotransferase system, enzyme I

2 of 2

2.82

0.95

0.0192

IPR023151

PEP-utilising enzyme, conserved site

2 of 3

2.65

0.95

0.0192

(more ...)

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