mnt protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

mnt

BHLH domain-containing protein. (463 aa)

Predicted Functional Partners:

max

0.921

mlx

0.678

ENSCMIP00000000768

0.590

mxd4

0.553

sin3a

0.527

sin3b

0.527

rnf2

0.527

myc

0.493

ENSCMIP00000004396

0.470

kdm5a

0.464

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000000768	ENSCMIP00000004396	ENSCMIP00000000768	ENSCMIP00000004396	Myc_N domain-containing protein.	BHLH domain-containing protein.	0.501
ENSCMIP00000000768	max	ENSCMIP00000000768	ENSCMIP00000022489	Myc_N domain-containing protein.	BHLH domain-containing protein.	0.943
ENSCMIP00000000768	mnt	ENSCMIP00000000768	ENSCMIP00000025499	Myc_N domain-containing protein.	BHLH domain-containing protein.	0.590
ENSCMIP00000000768	mxd4	ENSCMIP00000000768	ENSCMIP00000007525	Myc_N domain-containing protein.	BHLH domain-containing protein.	0.537
ENSCMIP00000000768	myc	ENSCMIP00000000768	ENSCMIP00000036565	Myc_N domain-containing protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.528
ENSCMIP00000004396	ENSCMIP00000000768	ENSCMIP00000004396	ENSCMIP00000000768	BHLH domain-containing protein.	Myc_N domain-containing protein.	0.501
ENSCMIP00000004396	kdm5a	ENSCMIP00000004396	ENSCMIP00000005253	BHLH domain-containing protein.	Uncharacterized protein.	0.493
ENSCMIP00000004396	max	ENSCMIP00000004396	ENSCMIP00000022489	BHLH domain-containing protein.	BHLH domain-containing protein.	0.871
ENSCMIP00000004396	mnt	ENSCMIP00000004396	ENSCMIP00000025499	BHLH domain-containing protein.	BHLH domain-containing protein.	0.470
ENSCMIP00000004396	rnf2	ENSCMIP00000004396	ENSCMIP00000043786	BHLH domain-containing protein.	RING-type domain-containing protein.	0.527
ENSCMIP00000004396	sin3a	ENSCMIP00000004396	ENSCMIP00000010947	BHLH domain-containing protein.	HDAC_interact domain-containing protein.	0.474
ENSCMIP00000004396	sin3b	ENSCMIP00000004396	ENSCMIP00000011913	BHLH domain-containing protein.	HDAC_interact domain-containing protein.	0.474
kdm5a	ENSCMIP00000004396	ENSCMIP00000005253	ENSCMIP00000004396	Uncharacterized protein.	BHLH domain-containing protein.	0.493
kdm5a	mnt	ENSCMIP00000005253	ENSCMIP00000025499	Uncharacterized protein.	BHLH domain-containing protein.	0.464
kdm5a	myc	ENSCMIP00000005253	ENSCMIP00000036565	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.524
kdm5a	sin3a	ENSCMIP00000005253	ENSCMIP00000010947	Uncharacterized protein.	HDAC_interact domain-containing protein.	0.622
kdm5a	sin3b	ENSCMIP00000005253	ENSCMIP00000011913	Uncharacterized protein.	HDAC_interact domain-containing protein.	0.622
max	ENSCMIP00000000768	ENSCMIP00000022489	ENSCMIP00000000768	BHLH domain-containing protein.	Myc_N domain-containing protein.	0.943
max	ENSCMIP00000004396	ENSCMIP00000022489	ENSCMIP00000004396	BHLH domain-containing protein.	BHLH domain-containing protein.	0.871
max	mlx	ENSCMIP00000022489	ENSCMIP00000018705	BHLH domain-containing protein.	MAX-like protein X.	0.410

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 14

2.2

4.77

4.05e-11

GO:0000162

Tryptophan biosynthetic process

4 of 4

2.5

3.23

7.12e-07

GO:0046417

Chorismate metabolic process

3 of 9

2.02

1.85

0.00020

GO:0008652

Cellular amino acid biosynthetic process

7 of 99

1.35

1.81

7.12e-07

GO:0019438

Aromatic compound biosynthetic process

10 of 203

1.19

1.71

2.70e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 121

1.2

1.08

0.00060

GO:0016835

Carbon-oxygen lyase activity

4 of 46

1.44

1.03

0.0042

GO:0004834

Tryptophan synthase activity

2 of 2

2.5

1.03

0.0133

GO:0004106

Chorismate mutase activity

2 of 2

2.5

1.03

0.0133

GO:0016836

Hydro-lyase activity

3 of 37

1.41

0.7

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1270

0.4

0.28

0.0388

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30808357

(2019) Metabolic engineering of microorganisms for production of aromatic compounds.

4 of 8

2.2

2.52

1.05e-05

PMID:34584039

(2021) Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.

2 of 2

2.5

1.07

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1391

Aromatic amino acid biosynthesis, and Anthranilate synthase/para-aminobenzoate synthase like domain

10 of 15

2.32

7.99

3.90e-19

CL:1393

Tryptophan biosynthesis

5 of 6

2.42

4.23

4.38e-09

CL:1407

Chorismate metabolic process

3 of 7

2.13

1.88

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pha00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 18

2.15

5.67

5.08e-14

pha01230

Biosynthesis of amino acids

8 of 113

1.35

2.04

1.36e-08

pha00790

Folate biosynthesis

3 of 24

1.6

1.25

0.0018

pha01110

Biosynthesis of secondary metabolites

8 of 287

0.95

0.97

1.13e-05

pha01100

Metabolic pathways

8 of 632

0.6

0.46

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 12

2.27

5.34

3.03e-12

KW-0822

Tryptophan biosynthesis

5 of 5

2.5

4.45

2.07e-09

KW-0456

Lyase

9 of 133

1.33

2.1

1.40e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.5

0.84

0.0299

PF00425

Chorismate binding enzyme

2 of 2

2.5

0.84

0.0299

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.5

1.18

0.0068

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About