LOC103183945 protein (Callorhinchus milii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103183945

Uncharacterized protein. (310 aa)

Predicted Functional Partners:

cul5

0.720

asb6

0.597

eloc

0.595

ENSCMIP00000000239

0.581

Ankdd1b

0.551

ankrd1

0.551

rnf7

0.537

ENSCMIP00000003529

0.535

commd8

0.523

ENSCMIP00000003486

0.515

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankdd1b	ENSCMIP00000003486	ENSCMIP00000001099	ENSCMIP00000003486	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.534
Ankdd1b	LOC103183945	ENSCMIP00000001099	ENSCMIP00000027900	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.551
ENSCMIP00000000239	ENSCMIP00000003486	ENSCMIP00000000239	ENSCMIP00000003486	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.514
ENSCMIP00000000239	LOC103183945	ENSCMIP00000000239	ENSCMIP00000027900	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.581
ENSCMIP00000000239	ankrd1	ENSCMIP00000000239	ENSCMIP00000045771	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.542
ENSCMIP00000003486	Ankdd1b	ENSCMIP00000003486	ENSCMIP00000001099	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.534
ENSCMIP00000003486	ENSCMIP00000000239	ENSCMIP00000003486	ENSCMIP00000000239	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.514
ENSCMIP00000003486	LOC103183945	ENSCMIP00000003486	ENSCMIP00000027900	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.515
ENSCMIP00000003486	ankrd1	ENSCMIP00000003486	ENSCMIP00000045771	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.520
ENSCMIP00000003529	LOC103183945	ENSCMIP00000003529	ENSCMIP00000027900	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.535
LOC103183945	Ankdd1b	ENSCMIP00000027900	ENSCMIP00000001099	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.551
LOC103183945	ENSCMIP00000000239	ENSCMIP00000027900	ENSCMIP00000000239	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.581
LOC103183945	ENSCMIP00000003486	ENSCMIP00000027900	ENSCMIP00000003486	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.515
LOC103183945	ENSCMIP00000003529	ENSCMIP00000027900	ENSCMIP00000003529	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.535
LOC103183945	ankrd1	ENSCMIP00000027900	ENSCMIP00000045771	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.551
LOC103183945	asb6	ENSCMIP00000027900	ENSCMIP00000034729	Uncharacterized protein.	Uncharacterized protein.	0.597
LOC103183945	commd8	ENSCMIP00000027900	ENSCMIP00000024293	Uncharacterized protein.	COMM domain-containing protein.	0.523
LOC103183945	cul5	ENSCMIP00000027900	ENSCMIP00000020062	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.720
LOC103183945	eloc	ENSCMIP00000027900	ENSCMIP00000004246	Uncharacterized protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.595
LOC103183945	rnf7	ENSCMIP00000027900	ENSCMIP00000014654	Uncharacterized protein.	RING-box protein 2-like protein.	0.537

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.851

expected number of edges:

11

PPI enrichment p-value:

3.64e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

6 of 102

1.42

1.54

5.95e-05

GO:0007059

Chromosome segregation

2 of 10

1.95

0.77

0.0357

GO:0006810

Transport

7 of 642

0.69

0.44

0.0221

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

2 of 3

2.47

0.8

0.0355

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005887

Integral component of plasma membrane

3 of 54

1.39

0.7

0.0310

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37425997

(2023) Polymeric carbohydrates utilization separates microbiomes into niches: insights into the diversity of microbial carbohydrate-active enzymes in the inner shelf of the Pearl River Estuary, China.

2 of 3

2.47

1.15

0.0078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5389

Mixed, incl. MotA/TolQ/ExbB proton channel, and Protein of unknown function (DUF3450)

10 of 13

2.54

9.46

5.84e-21

CL:5392

MotA/TolQ/ExbB proton channel, and Protein of unknown function (DUF3450)

5 of 5

2.65

4.88

4.64e-10

CL:5403

Mixed, incl. MotA/TolQ/ExbB proton channel, and Protein of unknown function (DUF3450)

3 of 6

2.35

2.21

6.11e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

6 of 36

1.87

3.16

2.77e-08

KW-0735

Signal-anchor

2 of 4

2.35

1.23

0.0052

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 8

2.22

1.59

0.00098

PF01618

MotA/TolQ/ExbB proton channel family

3 of 8

2.22

1.59

0.00098

PF11932

Protein of unknown function (DUF3450)

2 of 2

2.65

1.2

0.0065

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037682

TonB, C-terminal

3 of 8

2.22

1.38

0.0025

IPR006260

TonB/TolA, C-terminal

3 of 8

2.22

1.38

0.0025

IPR002898

MotA/TolQ/ExbB proton channel

3 of 8

2.22

1.38

0.0025

IPR017270

Putative MotA/TolQ/ExbB family protein

2 of 2

2.65

1.05

0.0124

IPR016866

Uncharacterised conserved protein UCP028069

2 of 2

2.65

1.05

0.0124

(more ...)

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