Tpbg protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Tpbg

Uncharacterized protein. (370 aa)

Predicted Functional Partners:

ENSCMIP00000010333

0.580

ENSCMIP00000011053

0.580

adgrl2

0.580

adgrl3

0.580

adgrl1

0.580

ENSCMIP00000047002

0.580

rarb

0.529

rdh14

0.495

pou2f1

0.478

ntng1

0.465

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000010333	Tpbg	ENSCMIP00000010333	ENSCMIP00000028877	Uncharacterized protein.	Uncharacterized protein.	0.580
ENSCMIP00000011053	ENSCMIP00000047002	ENSCMIP00000011053	ENSCMIP00000047002	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	SUEL-type lectin domain-containing protein.	0.914
ENSCMIP00000011053	Tpbg	ENSCMIP00000011053	ENSCMIP00000028877	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.580
ENSCMIP00000047002	ENSCMIP00000011053	ENSCMIP00000047002	ENSCMIP00000011053	SUEL-type lectin domain-containing protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	0.914
ENSCMIP00000047002	Tpbg	ENSCMIP00000047002	ENSCMIP00000028877	SUEL-type lectin domain-containing protein.	Uncharacterized protein.	0.580
ENSCMIP00000047002	adgrl1	ENSCMIP00000047002	ENSCMIP00000046997	SUEL-type lectin domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.916
Tpbg	ENSCMIP00000010333	ENSCMIP00000028877	ENSCMIP00000010333	Uncharacterized protein.	Uncharacterized protein.	0.580
Tpbg	ENSCMIP00000011053	ENSCMIP00000028877	ENSCMIP00000011053	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	0.580
Tpbg	ENSCMIP00000047002	ENSCMIP00000028877	ENSCMIP00000047002	Uncharacterized protein.	SUEL-type lectin domain-containing protein.	0.580
Tpbg	adgrl1	ENSCMIP00000028877	ENSCMIP00000046997	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.580
Tpbg	adgrl2	ENSCMIP00000028877	ENSCMIP00000020159	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.580
Tpbg	adgrl3	ENSCMIP00000028877	ENSCMIP00000037572	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.580
Tpbg	ntng1	ENSCMIP00000028877	ENSCMIP00000021794	Uncharacterized protein.	Uncharacterized protein.	0.465
Tpbg	pou2f1	ENSCMIP00000028877	ENSCMIP00000000558	Uncharacterized protein.	POU domain protein.	0.478
Tpbg	rarb	ENSCMIP00000028877	ENSCMIP00000037357	Uncharacterized protein.	Retinoic acid receptor beta-like protein.	0.529
Tpbg	rdh14	ENSCMIP00000028877	ENSCMIP00000009227	Uncharacterized protein.	Uncharacterized protein.	0.495
adgrl1	ENSCMIP00000047002	ENSCMIP00000046997	ENSCMIP00000047002	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	SUEL-type lectin domain-containing protein.	0.916
adgrl1	Tpbg	ENSCMIP00000046997	ENSCMIP00000028877	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.580
adgrl2	Tpbg	ENSCMIP00000020159	ENSCMIP00000028877	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.580
adgrl3	Tpbg	ENSCMIP00000037572	ENSCMIP00000028877	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.580

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.623

expected number of edges:

10

PPI enrichment p-value:

2.77e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 340

1.06

1.39

2.78e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

11 of 341

1.06

1.4

1.61e-09

GO:0015562

Efflux transmembrane transporter activity

3 of 15

1.85

1.28

0.0028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

11 of 1202

0.52

0.44

0.00026

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6452

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein

11 of 29

2.13

7.43

2.33e-20

CL:6454

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein

10 of 23

2.19

7.21

1.83e-18

CL:6483

Palmitate, and Hydrophobe/amphiphile efflux-1 HAE1

5 of 6

2.47

4.41

2.18e-09

CL:6455

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein, barrel-sandwich domain

3 of 14

1.88

1.52

0.00081

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01501

beta-Lactam resistance

10 of 86

1.62

3.61

6.23e-14

map01503

Cationic antimicrobial peptide (CAMP) resistance

7 of 74

1.53

2.45

2.33e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990281

Efflux pump complex

5 of 14

2.11

3.5

3.35e-08

GOCC:1902495

Transmembrane transporter complex

7 of 42

1.78

3.4

7.02e-10

GOCC:0016021

Integral component of membrane

11 of 128

1.49

3.1

2.12e-14

GOCC:0098796

Membrane protein complex

10 of 124

1.46

2.81

1.57e-12

GOCC:0046930

Pore complex

3 of 29

1.57

1.17

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0564

Palmitate

3 of 3

2.55

2.41

3.18e-05

KW-0175

Coiled coil

10 of 373

0.98

1.15

1.32e-07

KW-1134

Transmembrane beta strand

3 of 29

1.57

1.07

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13533

Biotin-lipoyl like

5 of 10

2.25

3.46

1.04e-07

PF13437

HlyD family secretion protein

4 of 13

2.04

2.27

2.32e-05

PF02321

Outer membrane efflux protein

4 of 13

2.04

2.27

2.32e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006143

RND efflux pump, membrane fusion protein

6 of 12

2.25

4.15

2.41e-09

IPR032317

RND efflux pump, membrane fusion protein, barrel-sandwich domain

5 of 11

2.21

3.31

1.86e-07

IPR003423

Outer membrane efflux protein

4 of 13

2.04

2.18

3.78e-05

IPR010131

RND efflux system, outer membrane lipoprotein, NodT

3 of 3

2.55

2.11

0.00012

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