rragd protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

rragd

Uncharacterized protein. (359 aa)

Predicted Functional Partners:

LOC103177256

0.990

mtor

0.988

rptor

0.986

Lamtor2

0.982

lamtor5

0.981

lamtor3

0.979

lamtor4

0.977

mlst8

0.975

deptor

0.905

LOC103190484

0.905

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103177256	LOC103190484	ENSCMIP00000008663	ENSCMIP00000028925	Uncharacterized protein.	DEP domain-containing mTOR-interacting protein-like protein.	0.918
LOC103177256	Lamtor2	ENSCMIP00000008663	ENSCMIP00000007235	Uncharacterized protein.	Robl_LC7 domain-containing protein.	0.998
LOC103177256	deptor	ENSCMIP00000008663	ENSCMIP00000024675	Uncharacterized protein.	Uncharacterized protein.	0.918
LOC103177256	lamtor3	ENSCMIP00000008663	ENSCMIP00000038960	Uncharacterized protein.	Uncharacterized protein.	0.997
LOC103177256	lamtor4	ENSCMIP00000008663	ENSCMIP00000016481	Uncharacterized protein.	Uncharacterized protein.	0.994
LOC103177256	lamtor5	ENSCMIP00000008663	ENSCMIP00000033212	Uncharacterized protein.	Hepatitis B virus X-interacting protein-like protein.	0.997
LOC103177256	mlst8	ENSCMIP00000008663	ENSCMIP00000011012	Uncharacterized protein.	Target of rapamycin complex subunit lst8.	0.993
LOC103177256	mtor	ENSCMIP00000008663	ENSCMIP00000004293	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.999
LOC103177256	rptor	ENSCMIP00000008663	ENSCMIP00000047956	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.998
LOC103177256	rragd	ENSCMIP00000008663	ENSCMIP00000029844	Uncharacterized protein.	Uncharacterized protein.	0.990
LOC103190484	LOC103177256	ENSCMIP00000028925	ENSCMIP00000008663	DEP domain-containing mTOR-interacting protein-like protein.	Uncharacterized protein.	0.918
LOC103190484	deptor	ENSCMIP00000028925	ENSCMIP00000024675	DEP domain-containing mTOR-interacting protein-like protein.	Uncharacterized protein.	0.901
LOC103190484	mlst8	ENSCMIP00000028925	ENSCMIP00000011012	DEP domain-containing mTOR-interacting protein-like protein.	Target of rapamycin complex subunit lst8.	0.955
LOC103190484	mtor	ENSCMIP00000028925	ENSCMIP00000004293	DEP domain-containing mTOR-interacting protein-like protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.990
LOC103190484	rptor	ENSCMIP00000028925	ENSCMIP00000047956	DEP domain-containing mTOR-interacting protein-like protein.	WD_REPEATS_REGION domain-containing protein.	0.986
LOC103190484	rragd	ENSCMIP00000028925	ENSCMIP00000029844	DEP domain-containing mTOR-interacting protein-like protein.	Uncharacterized protein.	0.905
Lamtor2	LOC103177256	ENSCMIP00000007235	ENSCMIP00000008663	Robl_LC7 domain-containing protein.	Uncharacterized protein.	0.998
Lamtor2	lamtor3	ENSCMIP00000007235	ENSCMIP00000038960	Robl_LC7 domain-containing protein.	Uncharacterized protein.	0.999
Lamtor2	lamtor4	ENSCMIP00000007235	ENSCMIP00000016481	Robl_LC7 domain-containing protein.	Uncharacterized protein.	0.999
Lamtor2	lamtor5	ENSCMIP00000007235	ENSCMIP00000033212	Robl_LC7 domain-containing protein.	Hepatitis B virus X-interacting protein-like protein.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.782

expected number of edges:

11

PPI enrichment p-value:

0.000292

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

3 of 47

2.11

1.09

0.0090

GO:0006534

Cysteine metabolic process

2 of 8

2.71

1.03

0.0133

GO:0009064

Glutamine family amino acid metabolic process

3 of 65

1.97

1.01

0.0117

GO:0006750

Glutathione biosynthetic process

2 of 10

2.61

1.01

0.0146

GO:1901605

Alpha-amino acid metabolic process

4 of 170

1.68

1.0

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 44

2.14

1.28

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005814

Centriole

3 of 108

1.75

0.83

0.0239

GO:0005813

Centrosome

4 of 413

1.29

0.71

0.0239

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28614

Glutathione metabolism, and Oxidoreductase activity, acting on a sulfur group of donors

8 of 127

2.11

5.12

1.06e-12

CL:28680

Gamma-glutamyltranspeptidase, and Glutamate-cysteine ligase complex

3 of 7

2.94

2.75

9.75e-06

CL:28789

Mixed, incl. Metalloaminopeptidase activity, and Aspartate and asparagine metabolism

4 of 38

2.33

2.64

8.07e-06

CL:28620

Glutathione conjugation, and Glutathione peroxidase

4 of 39

2.32

2.63

8.07e-06

CL:28845

Negative regulation of cilium assembly, and Domain in ubiquitin-specific proteases.

3 of 10

2.79

2.57

1.94e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00480

Glutathione metabolism

5 of 126

1.91

2.78

5.66e-07

map00270

Cysteine and methionine metabolism

4 of 78

2.02

2.52

5.36e-06

map00250

Alanine, aspartate and glutamate metabolism

2 of 64

1.8

0.84

0.0229

map04216

Ferroptosis

2 of 74

1.74

0.82

0.0243

map01100

Metabolic pathways

9 of 3053

0.78

0.72

4.65e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174403

Glutathione synthesis and recycling

4 of 19

2.63

3.37

4.63e-07

MAP-156590

Glutathione conjugation

4 of 34

2.38

2.96

1.92e-06

MAP-156580

Phase II - Conjugation of compounds

4 of 95

1.93

2.02

6.44e-05

MAP-211859

Biological oxidations

4 of 254

1.51

1.17

0.0022

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 105

1.76

1.11

0.0058

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097721

Ciliary vesicle

2 of 4

3.01

1.32

0.0042

GOCC:0005814

Centriole

3 of 59

2.01

1.23

0.0042

GOCC:0005815

Microtubule organizing center

4 of 215

1.58

1.1

0.0042

GOCC:0005813

Centrosome

3 of 120

1.71

0.99

0.0098

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