epm2a protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

epm2a

Uncharacterized protein. (338 aa)

Predicted Functional Partners:

nhlrc1

0.891

stbd1

0.669

nfu1

0.576

agl

0.553

LOC103181954

0.548

mapk6

0.445

ENSCMIP00000001166

0.438

LOC103185862

0.432

LOC103191014

0.416

nmd3

0.403

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000001166	epm2a	ENSCMIP00000001166	ENSCMIP00000030596	TFIIS-type domain-containing protein.	Uncharacterized protein.	0.438
LOC103181954	LOC103191014	ENSCMIP00000020265	ENSCMIP00000019682	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.416
LOC103181954	epm2a	ENSCMIP00000020265	ENSCMIP00000030596	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.548
LOC103181954	nmd3	ENSCMIP00000020265	ENSCMIP00000044987	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.	0.431
LOC103185862	epm2a	ENSCMIP00000009280	ENSCMIP00000030596	Nfu_N domain-containing protein.	Uncharacterized protein.	0.432
LOC103191014	LOC103181954	ENSCMIP00000019682	ENSCMIP00000020265	Uncharacterized protein.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.416
LOC103191014	epm2a	ENSCMIP00000019682	ENSCMIP00000030596	Uncharacterized protein.	Uncharacterized protein.	0.416
agl	epm2a	ENSCMIP00000009044	ENSCMIP00000030596	Uncharacterized protein.	Uncharacterized protein.	0.553
agl	nhlrc1	ENSCMIP00000009044	ENSCMIP00000018290	Uncharacterized protein.	RING-type domain-containing protein.	0.574
agl	stbd1	ENSCMIP00000009044	ENSCMIP00000002489	Uncharacterized protein.	CBM20 domain-containing protein.	0.570
epm2a	ENSCMIP00000001166	ENSCMIP00000030596	ENSCMIP00000001166	Uncharacterized protein.	TFIIS-type domain-containing protein.	0.438
epm2a	LOC103181954	ENSCMIP00000030596	ENSCMIP00000020265	Uncharacterized protein.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.548
epm2a	LOC103185862	ENSCMIP00000030596	ENSCMIP00000009280	Uncharacterized protein.	Nfu_N domain-containing protein.	0.432
epm2a	LOC103191014	ENSCMIP00000030596	ENSCMIP00000019682	Uncharacterized protein.	Uncharacterized protein.	0.416
epm2a	agl	ENSCMIP00000030596	ENSCMIP00000009044	Uncharacterized protein.	Uncharacterized protein.	0.553
epm2a	mapk6	ENSCMIP00000030596	ENSCMIP00000047152	Uncharacterized protein.	Mitogen-activated protein kinase 6.	0.445
epm2a	nfu1	ENSCMIP00000030596	ENSCMIP00000013262	Uncharacterized protein.	Nfu_N domain-containing protein.	0.576
epm2a	nhlrc1	ENSCMIP00000030596	ENSCMIP00000018290	Uncharacterized protein.	RING-type domain-containing protein.	0.891
epm2a	nmd3	ENSCMIP00000030596	ENSCMIP00000044987	Uncharacterized protein.	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.	0.403
epm2a	stbd1	ENSCMIP00000030596	ENSCMIP00000002489	Uncharacterized protein.	CBM20 domain-containing protein.	0.669

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

8.16e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 15

2.3

5.28

6.31e-12

GO:0046417

Chorismate metabolic process

4 of 6

2.46

3.07

1.32e-06

GO:0009423

Chorismate biosynthetic process

3 of 5

2.41

2.27

5.21e-05

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 2

2.63

1.51

0.0017

GO:0008652

Cellular amino acid biosynthetic process

5 of 108

1.3

1.27

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

3 of 6

2.33

1.74

0.00054

GO:0003856

3-dehydroquinate synthase activity

2 of 2

2.63

1.26

0.0051

GO:0016835

Carbon-oxygen lyase activity

4 of 52

1.52

1.2

0.0019

GO:0016829

Lyase activity

5 of 130

1.22

0.99

0.0019

GO:0003824

Catalytic activity

11 of 2283

0.32

0.24

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1157

Aromatic amino acid family biosynthetic process, and Anthranilate synthase component I-like

9 of 19

2.31

7.07

1.22e-16

CL:1159

Chorismate biosynthetic process

4 of 6

2.46

3.31

4.40e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

zga00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 23

2.27

8.0

6.95e-20

zga01230

Biosynthesis of amino acids

10 of 125

1.54

3.22

1.45e-13

zga01110

Biosynthesis of secondary metabolites

11 of 326

1.16

1.77

7.18e-12

zga01100

Metabolic pathways

11 of 716

0.82

0.89

2.77e-08

zga02024

Quorum sensing

2 of 26

1.52

0.69

0.0386

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 1110

0.54

0.36

0.0243

GOCC:0005622

Intracellular

10 of 1523

0.45

0.31

0.0243

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

3 of 11

2.07

1.76

0.00034

KW-0456

Lyase

6 of 116

1.35

1.54

2.15e-05

KW-0170

Cobalt

2 of 4

2.33

1.25

0.0049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00425

Chorismate binding enzyme

2 of 3

2.46

0.82

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030963

3-dehydroquinate synthase family

2 of 2

2.63

0.74

0.0466

IPR030960

3-dehydroquinate synthase domain

2 of 2

2.63

0.74

0.0466

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 3

2.46

0.73

0.0466

IPR005801

ADC synthase

2 of 3

2.46

0.73

0.0466

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