kcnc4 protein (Callorhinchus milii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

kcnc4

BTB domain-containing protein; Belongs to the potassium channel family. (632 aa)

Predicted Functional Partners:

fau

0.922

rpl26l1

0.719

rpl35

0.707

rpl29

0.707

rpl23a

0.704

rpl30

0.702

rpl31

0.702

rpl24

0.702

rpl35a

0.700

Rpl19

0.690

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Rpl19	fau	ENSCMIP00000042127	ENSCMIP00000005942	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Ubiquitin-like domain-containing protein.	0.999
Rpl19	kcnc4	ENSCMIP00000042127	ENSCMIP00000033251	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	BTB domain-containing protein; Belongs to the potassium channel family.	0.690
Rpl19	rpl23a	ENSCMIP00000042127	ENSCMIP00000043687	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	60S ribosomal protein L23a-like protein; Belongs to the universal ribosomal protein uL23 family.	0.999
Rpl19	rpl24	ENSCMIP00000042127	ENSCMIP00000047843	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	60S ribosomal protein L24.	0.999
Rpl19	rpl26l1	ENSCMIP00000042127	ENSCMIP00000028143	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Ribosomal protein L26 isoform 1.	0.999
Rpl19	rpl29	ENSCMIP00000042127	ENSCMIP00000020607	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family.	0.999
Rpl19	rpl30	ENSCMIP00000042127	ENSCMIP00000004616	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Ribosomal_L7Ae domain-containing protein.	0.999
Rpl19	rpl31	ENSCMIP00000042127	ENSCMIP00000042376	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Uncharacterized protein.	0.999
Rpl19	rpl35	ENSCMIP00000042127	ENSCMIP00000008741	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Uncharacterized protein.	0.999
Rpl19	rpl35a	ENSCMIP00000042127	ENSCMIP00000020637	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Uncharacterized protein.	0.999
fau	Rpl19	ENSCMIP00000005942	ENSCMIP00000042127	Ubiquitin-like domain-containing protein.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.999
fau	kcnc4	ENSCMIP00000005942	ENSCMIP00000033251	Ubiquitin-like domain-containing protein.	BTB domain-containing protein; Belongs to the potassium channel family.	0.922
fau	rpl23a	ENSCMIP00000005942	ENSCMIP00000043687	Ubiquitin-like domain-containing protein.	60S ribosomal protein L23a-like protein; Belongs to the universal ribosomal protein uL23 family.	0.999
fau	rpl24	ENSCMIP00000005942	ENSCMIP00000047843	Ubiquitin-like domain-containing protein.	60S ribosomal protein L24.	0.999
fau	rpl26l1	ENSCMIP00000005942	ENSCMIP00000028143	Ubiquitin-like domain-containing protein.	Ribosomal protein L26 isoform 1.	0.999
fau	rpl29	ENSCMIP00000005942	ENSCMIP00000020607	Ubiquitin-like domain-containing protein.	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family.	0.999
fau	rpl30	ENSCMIP00000005942	ENSCMIP00000004616	Ubiquitin-like domain-containing protein.	Ribosomal_L7Ae domain-containing protein.	0.999
fau	rpl31	ENSCMIP00000005942	ENSCMIP00000042376	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999
fau	rpl35	ENSCMIP00000005942	ENSCMIP00000008741	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999
fau	rpl35a	ENSCMIP00000005942	ENSCMIP00000020637	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006383

Transcription by RNA polymerase III

6 of 20

2.48

4.96

1.46e-10

GO:0006384

Transcription initiation from RNA polymerase III promoter

4 of 6

2.83

3.83

7.83e-08

GO:0006351

Transcription, DNA-templated

8 of 185

1.64

2.93

2.04e-09

GO:0006352

DNA-templated transcription, initiation

5 of 54

1.97

2.8

8.23e-07

GO:0070898

RNA polymerase III preinitiation complex assembly

2 of 2

3.0

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

3 of 16

2.28

1.61

0.00092

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.0

1.41

0.0028

GO:0000995

RNA polymerase III general transcription initiation factor activity

2 of 2

3.0

1.41

0.0028

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.61

1.31

0.0041

GO:0030151

Molybdenum ion binding

2 of 11

2.26

1.14

0.0077

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090576

RNA polymerase III transcription regulator complex

5 of 5

3.0

5.49

6.98e-11

GO:0000127

Transcription factor TFIIIC complex

3 of 3

3.0

2.96

4.07e-06

GO:0000126

Transcription factor TFIIIB complex

2 of 2

3.0

1.64

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:834

Transcription factor TFIIIC complex, and Histidine phosphatase superfamily, clade-1

4 of 5

2.91

3.77

1.14e-07

CL:1661

RNA polymerase III complex, and Transcription factor TFIIIB complex

3 of 20

2.18

1.84

0.00028

CL:13449

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Cytochrome b5, heme-binding site

2 of 7

2.46

1.42

0.0024

CL:1481

RNA Polymerase II Pre-transcription Events, and RNA polymerase

4 of 117

1.54

1.41

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76046

RNA Polymerase III Transcription Initiation

7 of 24

2.47

6.21

1.98e-13

MAP-74158

RNA Polymerase III Transcription

7 of 24

2.47

6.21

1.98e-13

MAP-74160

Gene expression (Transcription)

8 of 540

1.17

1.45

9.18e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 4

2.7

1.03

0.0135

PF00174

Oxidoreductase molybdopterin binding domain

2 of 4

2.7

1.03

0.0135

PF00970

Oxidoreductase FAD-binding domain

2 of 7

2.46

1.02

0.0135

PF00175

Oxidoreductase NAD-binding domain

2 of 15

2.13

0.82

0.0304

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 4

2.7

0.79

0.0374

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 4

2.7

0.79

0.0374

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

2 of 4

2.7

0.79

0.0374

IPR000572

Oxidoreductase, molybdopterin-binding domain

2 of 4

2.7

0.79

0.0374

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

2 of 7

2.46

0.78

0.0374

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00384

DNA binding domain with preference for A/T rich regions

2 of 11

2.26

0.9

0.0218

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 24

1.92

0.71

0.0452

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