ENSCMIP00000034734 protein (Callorhinchus milii)

Nodes:

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ENSCMIP00000034734

Uncharacterized protein. (474 aa)

Predicted Functional Partners:

Rc3h2

0.900

mysm1

0.623

trip12

0.551

helz

0.541

rc3h1

0.517

LOC103171676

0.484

LOC103191460

0.484

LOC103189438

0.484

cnot2

0.469

cnot9

0.463

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000034734	LOC103171676	ENSCMIP00000034734	ENSCMIP00000000078	Uncharacterized protein.	Uncharacterized protein.	0.484
ENSCMIP00000034734	LOC103189438	ENSCMIP00000034734	ENSCMIP00000028110	Uncharacterized protein.	CNOT1_HEAT domain-containing protein.	0.484
ENSCMIP00000034734	LOC103191460	ENSCMIP00000034734	ENSCMIP00000009119	Uncharacterized protein.	Uncharacterized protein.	0.484
ENSCMIP00000034734	Rc3h2	ENSCMIP00000034734	ENSCMIP00000034741	Uncharacterized protein.	Uncharacterized protein.	0.900
ENSCMIP00000034734	cnot2	ENSCMIP00000034734	ENSCMIP00000047943	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.469
ENSCMIP00000034734	cnot9	ENSCMIP00000034734	ENSCMIP00000015506	Uncharacterized protein.	Uncharacterized protein.	0.463
ENSCMIP00000034734	helz	ENSCMIP00000034734	ENSCMIP00000048995	Uncharacterized protein.	C3H1-type domain-containing protein.	0.541
ENSCMIP00000034734	mysm1	ENSCMIP00000034734	ENSCMIP00000047519	Uncharacterized protein.	Uncharacterized protein.	0.623
ENSCMIP00000034734	rc3h1	ENSCMIP00000034734	ENSCMIP00000003045	Uncharacterized protein.	Uncharacterized protein.	0.517
ENSCMIP00000034734	trip12	ENSCMIP00000034734	ENSCMIP00000016712	Uncharacterized protein.	Putative E3 ubiquitin-protein ligase TRIP12.	0.551
LOC103171676	ENSCMIP00000034734	ENSCMIP00000000078	ENSCMIP00000034734	Uncharacterized protein.	Uncharacterized protein.	0.484
LOC103171676	LOC103189438	ENSCMIP00000000078	ENSCMIP00000028110	Uncharacterized protein.	CNOT1_HEAT domain-containing protein.	0.963
LOC103171676	LOC103191460	ENSCMIP00000000078	ENSCMIP00000009119	Uncharacterized protein.	Uncharacterized protein.	0.965
LOC103171676	Rc3h2	ENSCMIP00000000078	ENSCMIP00000034741	Uncharacterized protein.	Uncharacterized protein.	0.484
LOC103171676	cnot2	ENSCMIP00000000078	ENSCMIP00000047943	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.955
LOC103171676	cnot9	ENSCMIP00000000078	ENSCMIP00000015506	Uncharacterized protein.	Uncharacterized protein.	0.954
LOC103171676	helz	ENSCMIP00000000078	ENSCMIP00000048995	Uncharacterized protein.	C3H1-type domain-containing protein.	0.495
LOC103171676	rc3h1	ENSCMIP00000000078	ENSCMIP00000003045	Uncharacterized protein.	Uncharacterized protein.	0.550
LOC103171676	trip12	ENSCMIP00000000078	ENSCMIP00000016712	Uncharacterized protein.	Putative E3 ubiquitin-protein ligase TRIP12.	0.700
LOC103189438	ENSCMIP00000034734	ENSCMIP00000028110	ENSCMIP00000034734	CNOT1_HEAT domain-containing protein.	Uncharacterized protein.	0.484

page 1 of 5

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008654

Phospholipid biosynthetic process

10 of 209

1.99

5.62

5.76e-16

GO:0006650

Glycerophospholipid metabolic process

10 of 262

1.89

5.04

2.62e-15

GO:0006658

Phosphatidylserine metabolic process

5 of 21

2.69

4.91

4.35e-10

GO:0046474

Glycerophospholipid biosynthetic process

8 of 178

1.96

4.53

3.64e-12

GO:0046470

Phosphatidylcholine metabolic process

5 of 32

2.5

4.4

2.65e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016780

Phosphotransferase activity, for other substituted phosphate groups

6 of 23

2.72

5.98

3.29e-12

GO:0106245

L-serine-phosphatidylethanolamine phosphatidyltransferase activity

3 of 3

3.31

3.12

2.32e-06

GO:0017169

CDP-alcohol phosphatidyltransferase activity

3 of 5

3.09

2.95

4.32e-06

GO:0106258

L-serine-phosphatidylcholine phosphatidyltransferase activity

2 of 2

3.31

1.8

0.00058

GO:0004307

Ethanolaminephosphotransferase activity

2 of 2

3.31

1.8

0.00058

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

9 of 878

1.32

1.96

1.49e-08

GO:0031090

Organelle membrane

11 of 2810

0.9

1.02

3.15e-08

GO:0012505

Endomembrane system

10 of 3368

0.78

0.75

1.03e-05

GO:0016021

Integral component of membrane

10 of 5655

0.56

0.44

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17732

Mixed, incl. Synthesis of PA, and Phosphotransferase activity, for other substituted phosphate groups

11 of 63

2.55

10.95

1.09e-24

CL:17838

Mixed, incl. Synthesis of PS, and Ethanolaminephosphotransferase activity

7 of 10

3.15

9.12

1.06e-17

CL:17841

Synthesis of PS, and Glycine betaine metabolic process

4 of 5

3.21

4.67

3.05e-09

CL:17734

Synthesis of PA, and Lysophospholipase activity

4 of 51

2.2

2.6

7.00e-06

CL:17736

Mixed, incl. CDP-diacylglycerol metabolic process, and glycerol-3-phosphate metabolic process

3 of 32

2.28

1.83

0.00033

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

11 of 197

2.06

7.11

6.78e-21

map00440

Phosphonate and phosphinate metabolism

3 of 9

2.83

3.1

1.92e-06

map00565

Ether lipid metabolism

3 of 80

1.88

1.66

0.00039

map01100

Metabolic pathways

10 of 3053

0.82

0.84

1.92e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483206

Glycerophospholipid biosynthesis

11 of 190

2.07

7.03

3.87e-20

MAP-1483257

Phospholipid metabolism

11 of 318

1.85

5.35

4.88e-18

MAP-1483101

Synthesis of PS

3 of 3

3.31

3.44

5.87e-07

MAP-556833

Metabolism of lipids

11 of 986

1.36

2.46

7.22e-13

MAP-1483213

Synthesis of PE

3 of 18

2.53

2.4

3.24e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0594

Phospholipid biosynthesis

2 of 9

2.66

1.3

0.0042

KW-1133

Transmembrane helix

10 of 6095

0.52

0.4

0.0042

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03034

Phosphatidyl serine synthase

3 of 3

3.31

2.99

4.00e-06

PF01066

CDP-alcohol phosphatidyltransferase

3 of 6

3.01

2.79

8.39e-06

PF03062

MBOAT, membrane-bound O-acyltransferase family

2 of 14

2.46

0.93

0.0198

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