ikzf2 protein (Callorhinchus milii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ikzf2

Uncharacterized protein. (521 aa)

Predicted Functional Partners:

nt5e

0.618

gmpr

0.617

crbn

0.580

fgl2

0.546

rc3h1

0.530

bcas1

0.528

ahcyl2

0.521

rad21

0.493

ddb1

0.462

tox2

0.416

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ahcyl2	bcas1	ENSCMIP00000031588	ENSCMIP00000032386	Adenosylhomocysteinase.	Uncharacterized protein.	0.526
ahcyl2	ikzf2	ENSCMIP00000031588	ENSCMIP00000035129	Adenosylhomocysteinase.	Uncharacterized protein.	0.521
ahcyl2	tox2	ENSCMIP00000031588	ENSCMIP00000033317	Adenosylhomocysteinase.	TOX high mobility group box family member 2-like protein.	0.520
bcas1	ahcyl2	ENSCMIP00000032386	ENSCMIP00000031588	Uncharacterized protein.	Adenosylhomocysteinase.	0.526
bcas1	ikzf2	ENSCMIP00000032386	ENSCMIP00000035129	Uncharacterized protein.	Uncharacterized protein.	0.528
bcas1	tox2	ENSCMIP00000032386	ENSCMIP00000033317	Uncharacterized protein.	TOX high mobility group box family member 2-like protein.	0.546
crbn	ddb1	ENSCMIP00000032258	ENSCMIP00000026284	Uncharacterized protein.	CPSF_A domain-containing protein.	0.978
crbn	ikzf2	ENSCMIP00000032258	ENSCMIP00000035129	Uncharacterized protein.	Uncharacterized protein.	0.580
ddb1	crbn	ENSCMIP00000026284	ENSCMIP00000032258	CPSF_A domain-containing protein.	Uncharacterized protein.	0.978
ddb1	ikzf2	ENSCMIP00000026284	ENSCMIP00000035129	CPSF_A domain-containing protein.	Uncharacterized protein.	0.462
fgl2	ikzf2	ENSCMIP00000034642	ENSCMIP00000035129	Fibrinogen-like 2.	Uncharacterized protein.	0.546
gmpr	ikzf2	ENSCMIP00000029217	ENSCMIP00000035129	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Uncharacterized protein.	0.617
gmpr	nt5e	ENSCMIP00000029217	ENSCMIP00000015555	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.916
ikzf2	ahcyl2	ENSCMIP00000035129	ENSCMIP00000031588	Uncharacterized protein.	Adenosylhomocysteinase.	0.521
ikzf2	bcas1	ENSCMIP00000035129	ENSCMIP00000032386	Uncharacterized protein.	Uncharacterized protein.	0.528
ikzf2	crbn	ENSCMIP00000035129	ENSCMIP00000032258	Uncharacterized protein.	Uncharacterized protein.	0.580
ikzf2	ddb1	ENSCMIP00000035129	ENSCMIP00000026284	Uncharacterized protein.	CPSF_A domain-containing protein.	0.462
ikzf2	fgl2	ENSCMIP00000035129	ENSCMIP00000034642	Uncharacterized protein.	Fibrinogen-like 2.	0.546
ikzf2	gmpr	ENSCMIP00000035129	ENSCMIP00000029217	Uncharacterized protein.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.617
ikzf2	nt5e	ENSCMIP00000035129	ENSCMIP00000015555	Uncharacterized protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.618

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.803

expected number of edges:

14

PPI enrichment p-value:

1.95e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007601

Visual perception

5 of 105

1.9

2.16

2.51e-05

GO:0051606

Detection of stimulus

5 of 202

1.62

1.69

0.00010

GO:0007602

Phototransduction

3 of 28

2.25

1.69

0.00063

GO:0007603

Phototransduction, visible light

2 of 4

2.92

1.39

0.0030

GO:0001580

Detection of chemical stimulus involved in sensory perception of bitter taste

2 of 5

2.82

1.33

0.0039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004703

G protein-coupled receptor kinase activity

3 of 8

2.8

2.28

6.64e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 34

2.39

3.91

1.89e-08

GO:0001750

Photoreceptor outer segment

4 of 49

2.13

2.69

3.57e-06

GO:0001917

Photoreceptor inner segment

3 of 36

2.14

1.97

0.00014

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25806532

(2015) Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.

5 of 7

3.08

5.85

1.60e-11

PMID:29321241

(2018) Evolution of the shut-off steps of vertebrate phototransduction.

3 of 5

3.0

3.41e-06

PMID:27296292

(2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity.

3 of 7

2.85

2.89

4.87e-06

PMID:35412676

(2022) Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction.

3 of 11

2.66

2.67

1.11e-05

PMID:30257895

(2018) Evolution of the calcium feedback steps of vertebrate phototransduction.

3 of 11

2.66

2.67

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27653

Rhodopsin, and GPCR kinase

6 of 11

2.96

6.77

2.08e-13

CL:27402

Mixed, incl. Amine ligand-binding receptors, and GTPase complex

11 of 172

2.03

6.6

2.76e-19

CL:27656

Methylation, and Vision

4 of 5

3.13

4.58

4.24e-09

CL:27492

Sensory perception of bitter taste, and Retinal cGMP phosphodiesterase, gamma subunit

4 of 5

3.13

4.58

4.24e-09

CL:27427

GTPase complex, and Prostanoid receptor

5 of 39

2.33

3.96

1.11e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04744

Phototransduction

10 of 39

2.63

10.84

1.47e-23

map04371

Apelin signaling pathway

3 of 144

1.54

0.98

0.0077

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2514856

The phototransduction cascade

9 of 42

2.55

8.78

4.24e-19

MAP-2514859

Inactivation, recovery and regulation of the phototransduction cascade

8 of 41

2.51

7.57

1.92e-16

MAP-2187338

Visual phototransduction

9 of 118

2.1

6.06

8.18e-16

MAP-9709957

Sensory Perception

10 of 264

1.8

4.65

2.10e-15

MAP-2485179

Activation of the phototransduction cascade

4 of 16

2.62

3.68

1.11e-07

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 10491

0.24

0.23

0.0194

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0001917

Photoreceptor inner segment

4 of 22

2.48

3.05

1.55e-06

GOCC:0005834

Heterotrimeric G-protein complex

3 of 10

2.7

2.42

3.41e-05

GOCC:0001750

Photoreceptor outer segment

2 of 38

1.94

0.76

0.0376

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0488

Methylation

2 of 2

3.22

1.77

0.00064

KW-0723

Serine/threonine-protein kinase

3 of 194

1.41

0.73

0.0270

KW-0807

Transducer

4 of 569

1.07

0.61

0.0270

KW-0547

Nucleotide-binding

5 of 993

0.92

0.54

0.0270

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000239

GPCR kinase

3 of 8

2.8

2.06

0.00017

IPR044926

RGS, subdomain 2

3 of 38

2.12

1.21

0.0052

IPR036305

RGS domain superfamily

3 of 38

2.12

1.21

0.0052

IPR016137

RGS domain

3 of 37

2.13

1.21

0.0052

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 5

2.82

1.17

0.0075

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00315

Regulator of G protein signalling domain

3 of 32

2.19

1.63

0.00078

SM00133

Extension to Ser/Thr-type protein kinases

3 of 54

1.97

1.41

0.0017

SM00275

G protein alpha subunit

2 of 15

2.35

1.06

0.0111

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