spire2 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

spire2

Uncharacterized protein. (314 aa)

Predicted Functional Partners:

grap2

0.814

tcf25

0.792

LOC103173046

0.756

grb2

0.730

nck1

0.620

nck2

0.620

vav3

0.601

vav2

0.601

syk

0.595

zap70

0.595

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103173046	grap2	ENSCMIP00000003537	ENSCMIP00000027220	SH3 domain-containing protein.	Uncharacterized protein.	0.806
LOC103173046	grb2	ENSCMIP00000003537	ENSCMIP00000043216	SH3 domain-containing protein.	Uncharacterized protein.	0.636
LOC103173046	spire2	ENSCMIP00000003537	ENSCMIP00000036245	SH3 domain-containing protein.	Uncharacterized protein.	0.756
grap2	LOC103173046	ENSCMIP00000027220	ENSCMIP00000003537	Uncharacterized protein.	SH3 domain-containing protein.	0.806
grap2	grb2	ENSCMIP00000027220	ENSCMIP00000043216	Uncharacterized protein.	Uncharacterized protein.	0.866
grap2	nck1	ENSCMIP00000027220	ENSCMIP00000038494	Uncharacterized protein.	Cytoplasmic protein.	0.625
grap2	nck2	ENSCMIP00000027220	ENSCMIP00000041157	Uncharacterized protein.	Cytoplasmic protein.	0.625
grap2	spire2	ENSCMIP00000027220	ENSCMIP00000036245	Uncharacterized protein.	Uncharacterized protein.	0.814
grap2	syk	ENSCMIP00000027220	ENSCMIP00000028258	Uncharacterized protein.	Tyrosine-protein kinase.	0.709
grap2	vav2	ENSCMIP00000027220	ENSCMIP00000035484	Uncharacterized protein.	Uncharacterized protein.	0.720
grap2	vav3	ENSCMIP00000027220	ENSCMIP00000021868	Uncharacterized protein.	Guanine nucleotide exchange factor VAV3.	0.720
grap2	zap70	ENSCMIP00000027220	ENSCMIP00000041908	Uncharacterized protein.	Tyrosine-protein kinase.	0.709
grb2	LOC103173046	ENSCMIP00000043216	ENSCMIP00000003537	Uncharacterized protein.	SH3 domain-containing protein.	0.636
grb2	grap2	ENSCMIP00000043216	ENSCMIP00000027220	Uncharacterized protein.	Uncharacterized protein.	0.866
grb2	nck1	ENSCMIP00000043216	ENSCMIP00000038494	Uncharacterized protein.	Cytoplasmic protein.	0.729
grb2	nck2	ENSCMIP00000043216	ENSCMIP00000041157	Uncharacterized protein.	Cytoplasmic protein.	0.722
grb2	spire2	ENSCMIP00000043216	ENSCMIP00000036245	Uncharacterized protein.	Uncharacterized protein.	0.730
grb2	syk	ENSCMIP00000043216	ENSCMIP00000028258	Uncharacterized protein.	Tyrosine-protein kinase.	0.746
grb2	vav2	ENSCMIP00000043216	ENSCMIP00000035484	Uncharacterized protein.	Uncharacterized protein.	0.862
grb2	vav3	ENSCMIP00000043216	ENSCMIP00000021868	Uncharacterized protein.	Guanine nucleotide exchange factor VAV3.	0.862

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 14

2.2

4.77

4.05e-11

GO:0000162

Tryptophan biosynthetic process

4 of 4

2.5

3.23

7.12e-07

GO:0046417

Chorismate metabolic process

3 of 9

2.02

1.85

0.00020

GO:0008652

Cellular amino acid biosynthetic process

7 of 99

1.35

1.81

7.12e-07

GO:0019438

Aromatic compound biosynthetic process

10 of 203

1.19

1.71

2.70e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 121

1.2

1.08

0.00060

GO:0016835

Carbon-oxygen lyase activity

4 of 46

1.44

1.03

0.0042

GO:0004834

Tryptophan synthase activity

2 of 2

2.5

1.03

0.0133

GO:0004106

Chorismate mutase activity

2 of 2

2.5

1.03

0.0133

GO:0016836

Hydro-lyase activity

3 of 37

1.41

0.7

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1270

0.4

0.28

0.0388

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30808357

(2019) Metabolic engineering of microorganisms for production of aromatic compounds.

4 of 8

2.2

2.52

1.05e-05

PMID:34584039

(2021) Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.

2 of 2

2.5

1.07

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1391

Aromatic amino acid biosynthesis, and Anthranilate synthase/para-aminobenzoate synthase like domain

10 of 15

2.32

7.99

3.90e-19

CL:1393

Tryptophan biosynthesis

5 of 6

2.42

4.23

4.38e-09

CL:1407

Chorismate metabolic process

3 of 7

2.13

1.88

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pha00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 18

2.15

5.67

5.08e-14

pha01230

Biosynthesis of amino acids

8 of 113

1.35

2.04

1.36e-08

pha00790

Folate biosynthesis

3 of 24

1.6

1.25

0.0018

pha01110

Biosynthesis of secondary metabolites

8 of 287

0.95

0.97

1.13e-05

pha01100

Metabolic pathways

8 of 632

0.6

0.46

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 12

2.27

5.34

3.03e-12

KW-0822

Tryptophan biosynthesis

5 of 5

2.5

4.45

2.07e-09

KW-0456

Lyase

9 of 133

1.33

2.1

1.40e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.5

0.84

0.0299

PF00425

Chorismate binding enzyme

2 of 2

2.5

0.84

0.0299

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.5

1.18

0.0068

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