STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pum2PUM-HD domain-containing protein. (1220 aa)    
Predicted Functional Partners:
dicer1
Uncharacterized protein; Belongs to the helicase family. Dicer subfamily.
    
 
 0.784
ENSCMIP00000002032
Uncharacterized protein.
    
 
 0.761
ENSCMIP00000045111
Nanos-type domain-containing protein; Belongs to the nanos family.
   
 
 0.725
gak
Uncharacterized protein.
   
 0.722
ago2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
   
 
 0.705
inip
Uncharacterized protein.
      
 0.693
clint1
Clathrin interactor 1.
   
 
 0.686
ENSCMIP00000000365
Nanos-type domain-containing protein; Belongs to the nanos family.
   
 
 0.679
ENSCMIP00000024511
Nanos-type domain-containing protein; Belongs to the nanos family.
   
 
 0.679
cnot8
CCR4-NOT transcription complex subunit 8.
    
 
 0.670
Your Current Organism:
Callorhinchus milii
NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe
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