abl1 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

abl1

Tyrosine-protein kinase. (1142 aa)

Predicted Functional Partners:

Crk

0.960

crkl

0.960

abi1

0.921

abl2

0.902

atm

0.820

ENSCMIP00000012735

0.796

ENSCMIP00000012742

0.796

Pwwp2a

0.737

abi2

0.687

LOC103182232

0.687

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Crk	ENSCMIP00000012735	ENSCMIP00000003571	ENSCMIP00000012735	Uncharacterized protein.	SH3 domain-containing protein.	0.454
Crk	ENSCMIP00000012742	ENSCMIP00000003571	ENSCMIP00000012742	Uncharacterized protein.	Uncharacterized protein.	0.454
Crk	abi1	ENSCMIP00000003571	ENSCMIP00000002889	Uncharacterized protein.	Uncharacterized protein.	0.601
Crk	abi2	ENSCMIP00000003571	ENSCMIP00000010937	Uncharacterized protein.	Uncharacterized protein.	0.480
Crk	abl1	ENSCMIP00000003571	ENSCMIP00000038657	Uncharacterized protein.	Tyrosine-protein kinase.	0.960
Crk	abl2	ENSCMIP00000003571	ENSCMIP00000039663	Uncharacterized protein.	Tyrosine-protein kinase.	0.960
Crk	crkl	ENSCMIP00000003571	ENSCMIP00000037461	Uncharacterized protein.	Crk-like protein.	0.901
ENSCMIP00000012735	Crk	ENSCMIP00000012735	ENSCMIP00000003571	SH3 domain-containing protein.	Uncharacterized protein.	0.454
ENSCMIP00000012735	abi2	ENSCMIP00000012735	ENSCMIP00000010937	SH3 domain-containing protein.	Uncharacterized protein.	0.433
ENSCMIP00000012735	abl1	ENSCMIP00000012735	ENSCMIP00000038657	SH3 domain-containing protein.	Tyrosine-protein kinase.	0.796
ENSCMIP00000012735	abl2	ENSCMIP00000012735	ENSCMIP00000039663	SH3 domain-containing protein.	Tyrosine-protein kinase.	0.796
ENSCMIP00000012735	crkl	ENSCMIP00000012735	ENSCMIP00000037461	SH3 domain-containing protein.	Crk-like protein.	0.454
ENSCMIP00000012742	Crk	ENSCMIP00000012742	ENSCMIP00000003571	Uncharacterized protein.	Uncharacterized protein.	0.454
ENSCMIP00000012742	abi2	ENSCMIP00000012742	ENSCMIP00000010937	Uncharacterized protein.	Uncharacterized protein.	0.417
ENSCMIP00000012742	abl1	ENSCMIP00000012742	ENSCMIP00000038657	Uncharacterized protein.	Tyrosine-protein kinase.	0.796
ENSCMIP00000012742	abl2	ENSCMIP00000012742	ENSCMIP00000039663	Uncharacterized protein.	Tyrosine-protein kinase.	0.796
ENSCMIP00000012742	crkl	ENSCMIP00000012742	ENSCMIP00000037461	Uncharacterized protein.	Crk-like protein.	0.454
LOC103182232	abl1	ENSCMIP00000019105	ENSCMIP00000038657	Uncharacterized protein.	Tyrosine-protein kinase.	0.687
LOC103182232	abl2	ENSCMIP00000019105	ENSCMIP00000039663	Uncharacterized protein.	Tyrosine-protein kinase.	0.687
Pwwp2a	abl1	ENSCMIP00000015922	ENSCMIP00000038657	PWWP domain-containing protein 2A.	Tyrosine-protein kinase.	0.737

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

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