bmf protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

bmf

Uncharacterized protein. (199 aa)

Predicted Functional Partners:

Bcl2

0.933

dnal4

0.822

bcl2l1

0.789

dynll1

0.749

dynll2

0.749

LOC103172502

0.678

ENSCMIP00000009870

0.678

LOC103181832

0.629

mapk8

0.627

mapk10

0.627

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	ENSCMIP00000009870	ENSCMIP00000014750	ENSCMIP00000009870	BH4_2 domain-containing protein.	Uncharacterized protein.	0.425
Bcl2	LOC103172502	ENSCMIP00000014750	ENSCMIP00000009445	BH4_2 domain-containing protein.	Uncharacterized protein.	0.425
Bcl2	LOC103181832	ENSCMIP00000014750	ENSCMIP00000048525	BH4_2 domain-containing protein.	Uncharacterized protein.	0.969
Bcl2	bcl2l1	ENSCMIP00000014750	ENSCMIP00000035465	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.971
Bcl2	bmf	ENSCMIP00000014750	ENSCMIP00000043746	BH4_2 domain-containing protein.	Uncharacterized protein.	0.933
Bcl2	mapk10	ENSCMIP00000014750	ENSCMIP00000013667	BH4_2 domain-containing protein.	Mitogen-activated protein kinase.	0.923
Bcl2	mapk8	ENSCMIP00000014750	ENSCMIP00000007698	BH4_2 domain-containing protein.	Mitogen-activated protein kinase.	0.923
ENSCMIP00000009870	Bcl2	ENSCMIP00000009870	ENSCMIP00000014750	Uncharacterized protein.	BH4_2 domain-containing protein.	0.425
ENSCMIP00000009870	LOC103181832	ENSCMIP00000009870	ENSCMIP00000048525	Uncharacterized protein.	Uncharacterized protein.	0.659
ENSCMIP00000009870	bcl2l1	ENSCMIP00000009870	ENSCMIP00000035465	Uncharacterized protein.	BH4_2 domain-containing protein.	0.429
ENSCMIP00000009870	bmf	ENSCMIP00000009870	ENSCMIP00000043746	Uncharacterized protein.	Uncharacterized protein.	0.678
LOC103172502	Bcl2	ENSCMIP00000009445	ENSCMIP00000014750	Uncharacterized protein.	BH4_2 domain-containing protein.	0.425
LOC103172502	LOC103181832	ENSCMIP00000009445	ENSCMIP00000048525	Uncharacterized protein.	Uncharacterized protein.	0.659
LOC103172502	bcl2l1	ENSCMIP00000009445	ENSCMIP00000035465	Uncharacterized protein.	BH4_2 domain-containing protein.	0.429
LOC103172502	bmf	ENSCMIP00000009445	ENSCMIP00000043746	Uncharacterized protein.	Uncharacterized protein.	0.678
LOC103181832	Bcl2	ENSCMIP00000048525	ENSCMIP00000014750	Uncharacterized protein.	BH4_2 domain-containing protein.	0.969
LOC103181832	ENSCMIP00000009870	ENSCMIP00000048525	ENSCMIP00000009870	Uncharacterized protein.	Uncharacterized protein.	0.659
LOC103181832	LOC103172502	ENSCMIP00000048525	ENSCMIP00000009445	Uncharacterized protein.	Uncharacterized protein.	0.659
LOC103181832	bcl2l1	ENSCMIP00000048525	ENSCMIP00000035465	Uncharacterized protein.	BH4_2 domain-containing protein.	0.990
LOC103181832	bmf	ENSCMIP00000048525	ENSCMIP00000043746	Uncharacterized protein.	Uncharacterized protein.	0.629

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.331

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006893

Golgi to plasma membrane transport

8 of 31

2.63

8.09

5.02e-17

GO:0006887

Exocytosis

11 of 152

2.08

6.95

1.53e-19

GO:0090522

Vesicle tethering involved in exocytosis

3 of 3

3.22

3.13

2.11e-06

GO:0140029

Exocytic process

4 of 47

2.15

2.52

9.07e-06

GO:2000535

Regulation of entry of bacterium into host cell

2 of 5

2.82

1.46

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031267

Small GTPase binding

6 of 213

1.67

2.23

2.99e-06

GO:0047485

Protein N-terminus binding

3 of 44

2.06

1.38

0.0022

GO:0005546

phosphatidylinositol-4,5-bisphosphate binding

3 of 51

1.99

1.34

0.0025

GO:0035091

Phosphatidylinositol binding

4 of 213

1.5

1.11

0.0030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

11 of 17

3.03

14.82

1.34e-29

GO:0090543

Flemming body

3 of 15

2.52

2.4

3.23e-05

GO:0030496

Midbody

4 of 107

1.79

1.9

7.18e-05

GO:0032584

Growth cone membrane

2 of 6

2.74

1.58

0.0013

GO:0030426

Growth cone

3 of 62

1.91

1.47

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20165

Exocyst

11 of 11

3.22

15.74

1.37e-30

CL:20168

Exocyst

6 of 6

3.22

7.89

2.82e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05132

Salmonella infection

4 of 262

1.41

1.09

0.0025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-264876

Insulin processing

11 of 27

2.83

13.33

1.00e-27

MAP-5620916

VxPx cargo-targeting to cilium

11 of 36

2.71

12.49

7.25e-27

MAP-5620920

Cargo trafficking to the periciliary membrane

11 of 61

2.48

10.64

8.39e-25

MAP-2980736

Peptide hormone metabolism

11 of 87

2.32

9.34

2.33e-23

MAP-5617833

Cilium Assembly

11 of 248

1.87

5.58

1.18e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000145

Exocyst

7 of 16

2.86

7.87

8.68e-16

GOCC:0071944

Cell periphery

9 of 2215

0.83

0.76

9.08e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0268

Exocytosis

4 of 6

3.05

4.53

4.79e-09

KW-0813

Transport

4 of 641

1.02

0.53

0.0446

KW-0175

Coiled coil

8 of 3376

0.6

0.39

0.0210

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09763

Exocyst complex component Sec3

2 of 2

3.22

1.33

0.0041

PF04091

Exocyst complex subunit Sec15-like

2 of 2

3.22

1.33

0.0041

PF06046

Exocyst complex component Sec6

2 of 6

2.74

1.21

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046361

Exocyst complex subunit Sec15, C-terminal

2 of 2

3.22

1.05

0.0130

IPR042045

Exocyst complex component EXOC6/Sec15, C-terminal, domain 1

2 of 2

3.22

1.05

0.0130

IPR042044

EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2

2 of 3

3.05

1.05

0.0130

IPR019160

Exocyst complex component Sec3, C-terminal

2 of 2

3.22

1.05

0.0130

IPR007225

Exocyst complex component EXOC6/Sec15

2 of 2

3.22

1.05

0.0130

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01313

Exocyst complex component SEC3 N-terminal PIP2 binding PH

2 of 4

2.92

1.34

0.0037

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