sec14l1 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

sec14l1

Uncharacterized protein. (746 aa)

Predicted Functional Partners:

sumf1

0.471

ankfy1

0.460

sec63

0.446

pcyt1b

0.433

pcyt1a

0.433

ENSCMIP00000004779

0.416

pld1

0.416

pld2

0.416

sestd1

0.410

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000004779	sec14l1	ENSCMIP00000004779	ENSCMIP00000043812	Uncharacterized protein.	Uncharacterized protein.	0.416
ankfy1	sec14l1	ENSCMIP00000025434	ENSCMIP00000043812	Uncharacterized protein.	Uncharacterized protein.	0.460
pcyt1a	pcyt1b	ENSCMIP00000031059	ENSCMIP00000012294	CTP_transf_like domain-containing protein.	CTP_transf_like domain-containing protein.	0.901
pcyt1a	sec14l1	ENSCMIP00000031059	ENSCMIP00000043812	CTP_transf_like domain-containing protein.	Uncharacterized protein.	0.433
pcyt1b	pcyt1a	ENSCMIP00000012294	ENSCMIP00000031059	CTP_transf_like domain-containing protein.	CTP_transf_like domain-containing protein.	0.901
pcyt1b	sec14l1	ENSCMIP00000012294	ENSCMIP00000043812	CTP_transf_like domain-containing protein.	Uncharacterized protein.	0.433
pld1	sec14l1	ENSCMIP00000016844	ENSCMIP00000043812	Phospholipase.	Uncharacterized protein.	0.416
pld2	sec14l1	ENSCMIP00000035409	ENSCMIP00000043812	Phospholipase.	Uncharacterized protein.	0.416
sec14l1	ENSCMIP00000004779	ENSCMIP00000043812	ENSCMIP00000004779	Uncharacterized protein.	Uncharacterized protein.	0.416
sec14l1	ankfy1	ENSCMIP00000043812	ENSCMIP00000025434	Uncharacterized protein.	Uncharacterized protein.	0.460
sec14l1	pcyt1a	ENSCMIP00000043812	ENSCMIP00000031059	Uncharacterized protein.	CTP_transf_like domain-containing protein.	0.433
sec14l1	pcyt1b	ENSCMIP00000043812	ENSCMIP00000012294	Uncharacterized protein.	CTP_transf_like domain-containing protein.	0.433
sec14l1	pld1	ENSCMIP00000043812	ENSCMIP00000016844	Uncharacterized protein.	Phospholipase.	0.416
sec14l1	pld2	ENSCMIP00000043812	ENSCMIP00000035409	Uncharacterized protein.	Phospholipase.	0.416
sec14l1	sec63	ENSCMIP00000043812	ENSCMIP00000035852	Uncharacterized protein.	Translocation protein SEC63-like protein.	0.446
sec14l1	sestd1	ENSCMIP00000043812	ENSCMIP00000032930	Uncharacterized protein.	SEC14 domain and spectrin repeat-containing protein 1.	0.410
sec14l1	sumf1	ENSCMIP00000043812	ENSCMIP00000032206	Uncharacterized protein.	FGE-sulfatase domain-containing protein.	0.471
sec63	sec14l1	ENSCMIP00000035852	ENSCMIP00000043812	Translocation protein SEC63-like protein.	Uncharacterized protein.	0.446
sestd1	sec14l1	ENSCMIP00000032930	ENSCMIP00000043812	SEC14 domain and spectrin repeat-containing protein 1.	Uncharacterized protein.	0.410
sumf1	sec14l1	ENSCMIP00000032206	ENSCMIP00000043812	FGE-sulfatase domain-containing protein.	Uncharacterized protein.	0.471

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

47

PPI enrichment p-value:

0.0318

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 309

1.77

4.66

3.02e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 155

2.03

6.04

7.21e-17

GO:0019843

rRNA binding

4 of 43

2.19

2.52

1.03e-05

GO:0003723

RNA binding

6 of 1039

0.98

0.69

0.0076

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 177

1.97

5.71

1.28e-16

GO:0044391

Ribosomal subunit

7 of 130

1.95

3.98

2.21e-10

GO:0015935

Small ribosomal subunit

4 of 48

2.14

2.6

5.79e-06

GO:0022626

Cytosolic ribosome

4 of 52

2.11

2.56

6.27e-06

GO:0015934

Large ribosomal subunit

3 of 81

1.79

1.29

0.0023

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14887

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

10 of 101

2.22

7.32

1.83e-18

CL:14896

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 90

2.22

6.89

5.10e-17

CL:14897

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 78

2.18

5.13

3.18e-12

CL:14902

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

6 of 69

2.16

4.31

4.44e-10

CL:14907

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

4 of 45

2.17

2.72

3.52e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 176

1.98

5.91

1.90e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 108

2.09

5.17

5.36e-13

MAP-72737

Cap-dependent Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-72613

Eukaryotic Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 94

2.09

4.68

1.66e-11

MAP-72689

Formation of a pool of free 40S subunits

7 of 98

2.08

4.63

1.75e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

6 of 51

2.29

4.51

4.67e-10

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 25

2.52

4.4

2.82e-09

GOCC:1990904

Ribonucleoprotein complex

6 of 402

1.4

1.66

1.22e-05

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 1957

0.78

0.55

0.0066

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 59

2.15

3.44

6.54e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04758

Ribosomal protein S30

3 of 3

3.22

2.86

6.73e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006846

Ribosomal protein S30

2 of 2

3.22

1.05

0.0130

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