p2ry2 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

p2ry2

G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)

Predicted Functional Partners:

p2rx1

0.780

adora1

0.658

pou2f3

0.521

pla2g4a

0.502

alox5ap

0.499

aldh18a1

0.426

dclk1

0.422

LOC103182067

0.406

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103182067	p2ry2	ENSCMIP00000014175	ENSCMIP00000043950	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.406
adora1	alox5ap	ENSCMIP00000000298	ENSCMIP00000046927	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.518
adora1	p2rx1	ENSCMIP00000000298	ENSCMIP00000008506	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.653
adora1	p2ry2	ENSCMIP00000000298	ENSCMIP00000043950	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.658
adora1	pla2g4a	ENSCMIP00000000298	ENSCMIP00000042093	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Phospholipase A2.	0.502
adora1	pou2f3	ENSCMIP00000000298	ENSCMIP00000023827	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	POU domain protein.	0.521
aldh18a1	p2ry2	ENSCMIP00000029682	ENSCMIP00000043950	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.426
alox5ap	adora1	ENSCMIP00000046927	ENSCMIP00000000298	Uncharacterized protein.	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.518
alox5ap	dclk1	ENSCMIP00000046927	ENSCMIP00000045573	Uncharacterized protein.	Uncharacterized protein.	0.652
alox5ap	p2rx1	ENSCMIP00000046927	ENSCMIP00000008506	Uncharacterized protein.	Uncharacterized protein.	0.495
alox5ap	p2ry2	ENSCMIP00000046927	ENSCMIP00000043950	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.499
alox5ap	pla2g4a	ENSCMIP00000046927	ENSCMIP00000042093	Uncharacterized protein.	Phospholipase A2.	0.676
alox5ap	pou2f3	ENSCMIP00000046927	ENSCMIP00000023827	Uncharacterized protein.	POU domain protein.	0.520
dclk1	alox5ap	ENSCMIP00000045573	ENSCMIP00000046927	Uncharacterized protein.	Uncharacterized protein.	0.652
dclk1	p2rx1	ENSCMIP00000045573	ENSCMIP00000008506	Uncharacterized protein.	Uncharacterized protein.	0.403
dclk1	p2ry2	ENSCMIP00000045573	ENSCMIP00000043950	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.422
dclk1	pla2g4a	ENSCMIP00000045573	ENSCMIP00000042093	Uncharacterized protein.	Phospholipase A2.	0.653
dclk1	pou2f3	ENSCMIP00000045573	ENSCMIP00000023827	Uncharacterized protein.	POU domain protein.	0.486
p2rx1	adora1	ENSCMIP00000008506	ENSCMIP00000000298	Uncharacterized protein.	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.653
p2rx1	alox5ap	ENSCMIP00000008506	ENSCMIP00000046927	Uncharacterized protein.	Uncharacterized protein.	0.495

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.838

expected number of edges:

12

PPI enrichment p-value:

1.72e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

10 of 148

1.8

4.55

6.70e-15

GO:0008380

RNA splicing

11 of 186

1.74

4.5

3.26e-16

GO:0006397

mRNA processing

11 of 221

1.67

4.06

1.03e-15

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003677

DNA binding

6 of 636

0.94

0.61

0.0149

GO:0003676

Nucleic acid binding

8 of 1224

0.78

0.55

0.0072

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000974

Prp19 complex

8 of 15

2.7

8.39

2.03e-17

GO:0005681

Spliceosomal complex

10 of 127

1.86

5.06

5.39e-16

GO:0071014

post-mRNA release spliceosomal complex

3 of 20

2.14

1.93

0.00017

GO:0005634

Nucleus

11 of 2103

0.69

0.65

4.28e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5935

mRNA Splicing, and U2-type spliceosomal complex

10 of 149

1.8

4.5

1.03e-14

CL:5936

mRNA Splicing

9 of 131

1.81

4.2

5.34e-13

CL:5940

mRNA Splicing

6 of 107

1.72

2.56

3.60e-07

CL:6057

Prp19 complex, and mRNA Splicing - Major Pathway

4 of 33

2.05

2.4

1.21e-05

CL:5944

mRNA Splicing

5 of 102

1.66

2.03

1.21e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

9 of 158

1.72

3.9

5.15e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

8 of 118

1.8

3.72

6.16e-11

MAP-72172

mRNA Splicing

8 of 129

1.76

3.61

6.16e-11

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

8 of 209

1.55

2.71

1.71e-09

MAP-8953854

Metabolism of RNA

8 of 565

1.12

1.3

2.98e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000974

Prp19 complex

7 of 13

2.7

7.15

1.02e-14

GOCC:0032991

Protein-containing complex

10 of 2145

0.64

0.52

0.00070

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00857

Isochorismatase family

5 of 13

2.55

4.37

3.67e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000868

Isochorismatase-like

5 of 12

2.59

4.24

7.63e-09

IPR036380

Isochorismatase-like superfamily

5 of 13

2.55

4.22

7.63e-09

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About